Abstract: A method of causing production and secretion into the bloodsream of a human patient of a biologically active enzyme for which the human patient suffers a deficiency; the method involves introducing into the human patient donor bone marrow stromal cells which have been transfected with a gene encoding the enzyme, so that the introduced cells can adhere to a bone cavity surface of the patient and produce and secrete the active enzyme.
Type:
Grant
Filed:
March 22, 1995
Date of Patent:
December 15, 1998
Assignees:
Stromagene Corporation, Gene Therapy Sciences, Inc.