Patents Assigned to Sucampo AG
  • Method for treating abdominal discomfort
    Patent number: 7795312
    Abstract: A method for treating irritable bowel syndrome in a mammalian subject includes administering an effective amount of 13,14-dihydro-15-keto-16,16-difluoro-18-methyl-prostaglandin E1 or 13,14-dihydro-15-keto-16,16-difluoro-prostaglandin E1, or a salt, ether, ester or amide thereof, to the subject. A method for treating abdominal discomfort associated with irritable bowel syndrome in a mammalian subject includes administering an effective amount of 13,14-dihydro-15-keto-16,16-difluoro-18-methyl-prostaglandin E1 or 13,14-dihydro-15-keto-16,16-difluoro-prostaglandin E1, or a salt, ether, ester or amide thereof, to the subject.
    Type: Grant
    Filed: December 29, 2003
    Date of Patent: September 14, 2010
    Assignee: Sucampo AG
    Inventors: Ryuji Ueno, Sachiko Kuno
  • METHOD FOR TREATING A DISEASE OR CONDITION RESPONSIVE TO OPENING OF C1C-2 CHANNEL
    Publication number: 20100204332
    Abstract: Disclosed is a method for prophylactic or therapeutic treatment of a condition or disease responsive to opening of ClC-2 channel, which comprises the step of administrating an effective amount of a ClC-2 channel opener to a subject in need of said treatment. According to the invention, a tissue or organ to be transplanted can also be treated with the ClC-2 channel opener.
    Type: Application
    Filed: April 16, 2010
    Publication date: August 12, 2010
    Applicant: Sucampo AG
    Inventor: Ryuji Ueno
  • METHOD FOR PREPARING PROSTAGLANDIN DERIVATIVE
    Publication number: 20100204491
    Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
    Type: Application
    Filed: April 19, 2010
    Publication date: August 12, 2010
    Applicants: SUCAMPO AG, R-TECH UENO, LTD.
    Inventors: Ryu HIRATA, Tatsuya Matsukawa, Kazuchiro Masuzaki, Ryuji Ueno
  • METHOD FOR PREPARING PROSTAGLANDIN DERIVATIVE
    Publication number: 20100204489
    Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
    Type: Application
    Filed: April 19, 2010
    Publication date: August 12, 2010
    Applicants: SUCAMPO AG, R-TECH UENO, LTD.
    Inventors: Ryu HIRATA, Tatsuya Matsukawa, Kazuhiro Masuzaki, Ryuji Ueno
  • Method for treating a disease or condition responsive to opening of C1C-2 channel
    Patent number: 7732487
    Abstract: Disclosed is a method for prophylactic or therapeutic treatment of a condition or disease responsive to opening of ClC-2 channel, which comprises the step of administrating an effective amount of a ClC-2 channel opener to a subject in need of said treatment. According to the invention, a tissue or organ to be transplanted can also be treated with the ClC-2 channel opener.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: June 8, 2010
    Assignee: Sucampo AG
    Inventor: Ryuji Ueno
  • PHARMACEUTICAL COMPOSITION
    Publication number: 20100087540
    Abstract: Provided is a pharmaceutical composition comprising: a) a prostaglandin compound; (b) a sugar alcohol; (c) a polyol; and (d) a pharmaceutically acceptable carrier. The composition of the present invention can be stored stably even in a polyethylene container. In addition, the composition of the present invention can be stored stably for a long term even if it comprises only a small amount of a preserving agent.
    Type: Application
    Filed: October 1, 2009
    Publication date: April 8, 2010
    Applicants: R-TECH UENO, LTD., SUCAMPO AG
    Inventors: Yasuhiro HARADA, Junichi Kawasaki, Tadashi Hayashi, Ryuji Ueno
  • METHOD FOR MODULATING STEM CELL GROWTH
    Publication number: 20090209643
    Abstract: In one embodiment, provided is a composition comprising a prostaglandin compound for modulating stem cell proliferation and/or differentiation in a mammalian subject. In another embodiment, the instant application is a composition comprising a prostaglandin compound for, which comprises a prostaglandin compound for modulating proliferation and/or differentiation of stem cells of a mammalian subject, in which the stem cells are contacted directly or indirectly with the composition of the invention.
    Type: Application
    Filed: February 18, 2009
    Publication date: August 20, 2009
    Applicant: SUCAMPO AG
    Inventors: Ryuji Ueno, Sachiko Kuno
  • PHARMACEUTICAL COMBINATION OF OPIOID AND PROSTAGLANDIN COMPOUND
    Publication number: 20090030072
    Abstract: Provided is a method for treating a condition or disease which is one of the indications for opioid use, which comprises administering a combination of: (a) a pharmaceutically effective amount of an opioid, and (b) a pharmaceutically effective amount of a prostaglandin (PG) compound represented by the formula (I): to a patient in need thereof.
    Type: Application
    Filed: July 2, 2008
    Publication date: January 29, 2009
    Applicant: SUCAMPO AG
    Inventor: Ryuji UENO
  • PHARMACEUTICAL COMPOSITION COMPRISING 11-DEOXY- PROSTAGLANDIN COMPOUND AND METHOD FOR STABILIZING THE COMPOUND
    Publication number: 20090022787
    Abstract: Provided is a pharmaceutical composition comprising a 11-deoxy-prostaglandin compound represented by formula (I): and a fatty acid ester. By mixing the compound of formula (I) and a fatty acid ester, the compound of formula (I) will be stabilized.
    Type: Application
    Filed: July 16, 2008
    Publication date: January 22, 2009
    Applicants: R-TECH UENO, LTD., SUCAMPO AG
    Inventors: Yasuhiro HARADA, Junichi Kawasaki, Yoshie Nishimura, Ryuji Ueno
  • PHARMACEUTICAL COMBINATION OF NSAID AND PROSTAGLANDIN COMPOUND
    Publication number: 20090012165
    Abstract: Provided is a method for treating a condition or disease which is one of the indications for NSAID use, which comprises administering a combination of: (a) a pharmaceutically effective amount of a NSAID, and (b) a pharmaceutically effective amount of a prostaglandin (PG) compound represented by the formula (I): to a subject in need thereof.
    Type: Application
    Filed: July 2, 2008
    Publication date: January 8, 2009
    Applicant: SUCAMPO AG
    Inventor: Ryuji UENO
  • Method for providing a cathartic effect
    Patent number: 7459583
    Abstract: The present invention relates to a novel method for providing a cathartic effort to a patient in need of cathartic induction, which comprises administering to the patient a cathartic-inducing effective amount of halogenated bioactive lipid comprising the following patial structure (I): The method is useful for relieving or preventing constipation, and also for cleansing the gastrointestinal tract.
    Type: Grant
    Filed: July 28, 2005
    Date of Patent: December 2, 2008
    Assignee: Sucampo AG
    Inventor: Ryuji Ueno
  • Method for Diagnosing or Predicting Susceptibility to Optic Neuropathy
    Publication number: 20080221050
    Abstract: Disclosed is a set of genetic polymorphisms linked to optic neuropathy including glaucoma and Leber's disease. Those polymorphisms are useful for diagnosing and predicting susceptibility to optic neuropathy.
    Type: Application
    Filed: March 18, 2005
    Publication date: September 11, 2008
    Applicant: SUCAMPO AG
    Inventor: Yukihiko Mashima
  • METHOD FOR PROTECTING MITOCHONDRIA
    Publication number: 20080207759
    Abstract: The present invention relates to a method for protecting mitochondria from damage in a mammalian subject, which comprises administering an effective amount of a prostaglandin compound to a subject in need thereof. Also provided is a method for treating mitochondrial dysfunction as well as a condition associated with mitochondrial dysfunction in a mammalian subject, which comprises administering an effective amount of a prostaglandin compound to a subject in need thereof.
    Type: Application
    Filed: February 26, 2008
    Publication date: August 28, 2008
    Applicant: SUCAMPO AG
    Inventors: Ryuji UENO, Sachiko Kuno, John Cuppoletti
  • Composition and method for stabilizing the same
    Patent number: 7417067
    Abstract: Disclosed is a novel composition comprising a novel bi-cyclic compound, which is expected to be pharmaceutically active, and a glyceride. The stability of the bi-cyclic compound can be improved significantly by dissolving the same in a glyceride.
    Type: Grant
    Filed: March 10, 2003
    Date of Patent: August 26, 2008
    Assignee: Sucampo AG
    Inventors: Ryuji Ueno, Tsuyoshi Habe
  • Compound for treatment of external secretion disorders
    Patent number: 7396946
    Abstract: Disclosed is a method for treatment of external secretion disorders, which comprises administering a fatty 5 acid derivative to a subject in need of said treatment. The method of the present invention is useful for treatment of at least one condition selected from hypolacrimation including disorder of basal tear secretion, dry-eye syndrome, hyposalivation and dry-mouth syndrome.
    Type: Grant
    Filed: November 23, 2004
    Date of Patent: July 8, 2008
    Assignee: Sucampo AG
    Inventor: Ryuji Ueno
  • METHOD FOR TREATING VASCULAR HYPERPERMEABLE DISEASE
    Publication number: 20080119462
    Abstract: The present invention provides a method for treating a vascular hyperpermeable disease (except macular edema), which method comprises administering to a patient in need thereof a vascular adhesion protein-1 (VAP-1) inhibitor in an amount sufficient to treat said patient for said disease.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 22, 2008
    Applicants: Sucampo AG, Astellas Pharma Inc.
    Inventors: Ryuji UENO, Akira Nagashima, Takayuki Inoue, Mitsuru Ohkubo, Kousei Yoshihara
  • METHOD FOR PROMOTING GASTROINTESTINAL BICARBONATE SECRETION
    Publication number: 20080070979
    Abstract: Provided is a method for promoting gastrointestinal bicarbonate secretion in a mammalian subject, which comprises administering an effective amount of a compound of Formula (I): to a subject in need thereof. The compound is also useful for protecting the gastrointestinal tract of a mammal from mucosal damage.
    Type: Application
    Filed: September 5, 2007
    Publication date: March 20, 2008
    Applicant: SUCAMPO AG
    Inventor: Ryuji UENO
  • Chloride channel opener
    Patent number: 7253295
    Abstract: Disclosed is a novel use of a prostaglandin compound as a chloride channel opener. According to the instant invention, chloride channels in a mammalian subject can be opened by a prostaglandin compound to facilitate chloride ion transportation.
    Type: Grant
    Filed: January 18, 2006
    Date of Patent: August 7, 2007
    Assignee: Sucampo AG
    Inventors: Ryuji Ueno, John Cuppoletti
  • Apoptosis inhibitor
    Patent number: 7129272
    Abstract: Disclosed is a method for treatment of a subject having a disease or condition associated with apoptosis, which comprises administering to the subject an effective amount of a 15-keto-prostaglandin compound represented by the following formula (I):
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: October 31, 2006
    Assignee: Sucampo AG
    Inventors: Ryuji Ueno, Yukihiko Mashima
  • Method for treating vascular hyperpermeable disease
    Publication number: 20060229346
    Abstract: The present invention provides a method for treating a vascular hyperpermeable disease (except macular edema), which method comprises administering to a patient in need thereof a vascular adhesion protein-1 (VAP-1) inhibitor in an amount sufficient to treat said patient for said disease. The agents are 2-acylamino thiazole compounds.
    Type: Application
    Filed: March 31, 2004
    Publication date: October 12, 2006
    Applicants: Sucampo AG, Astellas Pharma Inc.
    Inventors: Ryuji Ueno, Akira Nagashima, Takayuki Inoue, Mitsuru Ohkubo, Kousci Yoshihara