Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
Type:
Application
Filed:
April 5, 2004
Publication date:
September 23, 2004
Applicant:
Sugen, Inc.
Inventors:
Connie Li Sun, Chung Chen Wei, Peng Cho Tang, Marcel Koenig, Yong Zhou, Tomas Vojkovsky, Asaad S. Nematalla
Abstract: The present invention relates to certain 3-(4,5,6,7-tetrahydroindol-2-yl-methylidene)-2-indolinone derivatives that inhibit kinases, in particular Src kinase. Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing them are also disclosed.
Type:
Grant
Filed:
September 10, 2002
Date of Patent:
August 17, 2004
Assignee:
Sugen, Inc.
Inventors:
Congxin Liang, Huiping Guan, Peng Cho Tang, Robert A. Blake
Abstract: The present invention relates to 4-arylindolinones, as well as pharmaceutical compositions thereof, capable of modulating protein kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. The present invention also relates to methods for treating protein kinase related disorders.
Type:
Application
Filed:
December 16, 2003
Publication date:
August 12, 2004
Applicant:
Sugen, Inc.
Inventors:
Jingrong Cui, Ruofei Zhang, Hong Shen, Ji Yu Chu, Fang-Jie Zhang, Marcel Koenig, Steven Huy Do, Xiaoyuan Li, Chung Chen Wei, Peng Cho Tang
Abstract: The present invention relates to tricyclic quinoxaline compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein tyrosine kinases and therefore should be useful in the prevention and treatment of protein tyrosine kinase related cellular disorders such as cancer.
Abstract: The invention relates to a method of treating cancer by administering a combination of an indolinone compound with another chemotherapeutic agent.
Abstract: The present invention relates to certain 2-indolinone compounds which modulate the activity of protein kinases (“PKs”) and phosphatases. The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
Type:
Application
Filed:
December 2, 2003
Publication date:
July 29, 2004
Applicant:
Sugen, Inc.
Inventors:
Peng Cho Tang, G. Davis Harris, Xiaoyuan Li
Abstract: The invention relates to trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds and the physiologically acceptable salts and the prodrugs thereof. These compounds are expected to modulate the activity of protein tyrosine enzymes which are related to cellular signal transduction, in particular, protein tyrosine phosphatase, and therefore are expected to be useful in the prevention and treatment of disorders associated with abnormal protein tyrosine enzyme related cellular signal transduction such as cancer, diabetes, immuno-modulation, neurologic degenerative diseases, osteoporosis and infectious diseases. The invention also relates to the use of compounds containing fluoromethyl sulfonyl groups as phosphate mimics. These mimics may be used to inhibit, regulate or modulate the activity of a phosphate binding protein in a cell.
Type:
Application
Filed:
July 14, 2003
Publication date:
July 15, 2004
Applicant:
Sugen, Inc.
Inventors:
Ping Huang, Chung Chen Wei, Peng Cho Tang, Congxin (Chris) Liang, John Ramphal, Bahija Jallal, John Biltz, Xiaoyuan (Sharon) Li, Matt Mattson, Gerald McMahon, Marcel Koenig
Abstract: The present invention relates to certain substituted pyrroles which modulate the activity of protein kinases (“PKs”). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
Type:
Application
Filed:
October 7, 2003
Publication date:
July 15, 2004
Applicant:
Sugen, Inc.
Inventors:
Connie Li Sun, Peng Cho Tang, Denise Ockey
Abstract: The present invention is directed to Mannich base prodrugs of certain 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
Type:
Application
Filed:
December 24, 2003
Publication date:
July 1, 2004
Applicants:
Sugen, Inc., Pharmacia & Upjohn Company
Inventors:
Malcolm Wilson Moon, Walter Morozowich, Ping Gao, Peng Cho Tang
Abstract: The present invention relates to novel synthetic methods for the preparation of indolylquinones. The methods of the present invention are directed to synthetic reactions involving indoles and halo-quinones in solvent and in the presence of a metal carbonate. The invention also relates to bis- and mono-indolylquinones of high purity and pharmaceutical compositions containing the same.
Abstract: The present invention relates to novel 3-heteroarylidene-2-indolinone compounds and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
Abstract: The present invention relates to novel 3-heteroarylidene-2-indolinone compounds and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
Type:
Application
Filed:
September 8, 2003
Publication date:
May 27, 2004
Applicants:
SUGEN, INC., PHARMACIA & UPJOHN COMPANY
Inventors:
Huiping Guan, Congxin Liang, Connie Li Sun, Peng Cho Tang, Chung Chen Wei, Tomas Vojkovsky, Qingwu Jin, Paul M. Herrinton, Michael A. Mauragis
Abstract: The present invention relates to novel heteroaryl-carboxamides which modulate the activity of protein tyrosine kinases and therefore are expected to be useful in the treatment of abnormal protein tyrosine kinase activity driven disorders including cancer.
Type:
Application
Filed:
November 17, 2003
Publication date:
May 27, 2004
Applicant:
Sugen, Inc.
Inventors:
Gerald McMahon, Peng Cho Tang, Laura Kay Shawver, Klaus Peter Hirth
Abstract: The present invention relates to certain 4-heteroaryl-3-heteroarylidenyl-2-indolinones compounds and their physiologically acceptable salts which modulate the activity of protein kinases (“PKs”), in particular CDK2. The compounds of the present invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical composition containing these compounds and methods of preparing these compounds are also described.
Type:
Application
Filed:
August 27, 2003
Publication date:
May 20, 2004
Applicant:
Sugen, Inc.
Inventors:
Peng Cho Tang, Chung Chen Wei, Ping Huang, Jingrong Cui
Abstract: The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exchange factor biomarker, such as the novel GEF-H1S.
Type:
Application
Filed:
July 2, 2003
Publication date:
May 13, 2004
Applicant:
Sugen, Inc.
Inventors:
Tod R. Smeal, Marinella G. Callow, Bahija Jallal, Sergey Zozulya, Mikhail L. Gishizky
Abstract: The present invention relates to SAD polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for SAD related diseases or conditions characterized by an abnormal interaction between a SAD polypeptide and a SAD binding partner.
Type:
Application
Filed:
April 22, 2002
Publication date:
May 6, 2004
Applicant:
SUGEN, Inc.
Inventors:
Gregory D. Plowman, Susan Onrust, David Markby, Sara Courtneidge
Abstract: The present invention relates to the isolation of members of fungal-specific kinase families and their use in identifying compounds that modulate kinase activity and the use of those compounds as antifungal agents for therapeutic treatments and medicaments in animals and plants.
Abstract: The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds. The invention also relates to methods of modulating the function of protein tyrosine kinases using indolinone compounds and methods of treating diseases by modulating the function of protein tyrosine kinases and related signal transduction pathways.
Type:
Application
Filed:
June 11, 2003
Publication date:
April 8, 2004
Applicant:
SUGEN, INC.
Inventors:
Peng Cho Tang, Li Sun, Ngoc My Tran, Anh Thi Nguyen, Asaad Nematalla