Patents Assigned to Surface Logix, Inc.
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Patent number: 9656960Abstract: The present invention relates to compounds which are inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion. These compounds can be useful for the prevention and treatment of various diseases, particularly atherosclerosis and its clinical sequelae, for lowering serum lipids, and related ailments. The invention further relates to pharmaceutical compositions comprising the compounds and to methods of treating diseases, such as hypertriglyceridemia, hyperchylomicronemia, atherosclerosis, obesity, and related conditions using the compounds. A method for decreasing apolipoprotein B (apo B) secretion is also provided.Type: GrantFiled: March 17, 2015Date of Patent: May 23, 2017Assignee: Surface Logix, Inc.Inventors: Alessandra Bartolozzi, Stewart Campbell, Hope Foudoulakis, Enoch Kim, Paul Sweetnam, Yingfei Yang
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Patent number: 9440961Abstract: The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease.Type: GrantFiled: December 23, 2014Date of Patent: September 13, 2016Assignee: SURFACE LOGIX, INC.Inventors: Alessandra Bartolozzi, Stewart Campbell, Hope Foudoulakis, Brian Kirk, Siya Ram, Paul Sweetnam, Hemalatha Seshadri
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Patent number: 8980915Abstract: The present invention relates to compounds which are inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion. These compounds can be useful for the prevention and treatment of various diseases, particularly atherosclerosis and its clinical sequelae, for lowering serum lipids, and related ailments. The invention further relates to pharmaceutical compositions comprising the compounds and to methods of treating diseases, such as hypertriglyceridemia, hyperchylomicronemia, atherosclerosis, obesity, and related conditions using the compounds. A method for decreasing apolipoprotein B (apo B) secretion is also provided.Type: GrantFiled: April 19, 2006Date of Patent: March 17, 2015Assignee: Surface Logix, Inc.Inventors: Alessandra Bartolozzi, Stewart Campbell, Hope Foudoulakis, Enoch Kim, Paul Sweetnam, Yingfei Yang
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Patent number: 8916576Abstract: The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease.Type: GrantFiled: December 14, 2012Date of Patent: December 23, 2014Assignee: Surface Logix, Inc.Inventors: Alessandra Bartolozzi, Stewart Campbell, Hope Foudoulakis, Brian Kirk, Siya Ram, Paul Sweetnam, Hemalatha Seshadri
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Patent number: 8853394Abstract: A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: or a pharmaceutically acceptable salt, stereoisomer, or hydrate thereof.Type: GrantFiled: December 7, 2012Date of Patent: October 7, 2014Assignee: Surface Logix, Inc.Inventors: Stewart Campbell, David Duffy, Michael Grogan, Steven Kates, Emanuele Ostuni, Olivier Schueller, Paul Sweetnam
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Publication number: 20130131047Abstract: The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease.Type: ApplicationFiled: December 14, 2012Publication date: May 23, 2013Applicant: SURFACE LOGIX, INC.Inventor: SURFACE LOGIX, INC.
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Publication number: 20130096114Abstract: A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: or a pharmaceutically acceptable salt, stereoisomer, or hydrate thereof.Type: ApplicationFiled: December 7, 2012Publication date: April 18, 2013Applicant: SURFACE LOGIX, INC.Inventor: SURFACE LOGIX, INC.
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Patent number: 8357693Abstract: The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease.Type: GrantFiled: March 27, 2006Date of Patent: January 22, 2013Assignee: Surface Logix, Inc.Inventors: Alessandra Bartolozzi, Stewart Campbell, Hope Foudoulakis, Brian Kirk, Siya Ram, Paul Sweetnam
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Publication number: 20110172422Abstract: The present invention relates to methods of modulating the pharmacokinetic and/or pharmacodynamic properties of a compound by attaching at least one functional unit or group to the compound, thereby improving its non-specific binding characteristics and/or pharmacokinetic properties. Compounds comprising at least one functional residue are provided, as are pharmaceutical compositions comprising said compounds.Type: ApplicationFiled: February 21, 2006Publication date: July 14, 2011Applicant: SURFACE LOGIX, INC.Inventors: Stewart Campbell, David Duffy, Michael Grogan, Steven Kates, Emanuele Ostuni, Olivier Schueller, Paul Sweetnam
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Publication number: 20100324037Abstract: A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: or a pharmaceutically acceptable salt, stereoisomer, or hydrate thereof.Type: ApplicationFiled: August 23, 2007Publication date: December 23, 2010Applicant: SURFACE LOGIX, INC.Inventors: Stewart Campbell, David Duffy, Michael Grogan, Steven Kates, Emanuele Ostuni, Olivier Schueller, Paul Sweetnam
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Publication number: 20100093719Abstract: A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: or pharmaceutically acceptable salt, stereoisomer, or hydrate thereof, wherein R1 is lower alkyl, R2 and R3 are independently selected from lower alkyl, and lower alkenyl and lower alkynyl, wherein the lower alkyl, lower alkenyl, and lower alkynyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO2, amino, acylamino, amido, carbonyl, and alkylthio, A is N or C—H, B is N, C—H, C—(SO2—R4), or C—CO—R4, D is N, C—H, C—(SO2—R4) or C—CO—R4, E is N or C—H, wherein only one of A, B or E may be N, and one of B or D is C—(SO2—R4) or C—CO—R4, R4 is a group having the formula: in which each R5, R6, R7 and R8 are independently selected from H and lower alkyl, wherein the lower alkyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO2, amino, acylamino, amido, carbonyl, and alkylthio; and additionally or alternatively R6 and R5Type: ApplicationFiled: September 30, 2009Publication date: April 15, 2010Applicant: SURFACE LOGIX, INC.Inventors: Stewart CAMPBELL, David DUFFY, Michael GROGAN, Steven KATES, Emanuele OSTUNI, Olivier SCHUELLER, Paul SWEETNAM
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Patent number: 7476523Abstract: A deformable stamp for patterning a surface. The stamp can be placed in contact with an entire 3-dimensional object, such as a rod, in a single step. The stamp can also be used to pattern the inside of a tube or rolled over a surface to form a continuous pattern. The stamp may also be used for fluidic patterning by flowing material through channels defined by raised and recessed portions in the surface of the stamp as it contacts the substrate. The stamp may be used to deposit self-assembled monolayers, biological materials, metals, polymers, ceramics, or a variety of other materials. The patterned substrates may be used in a variety of engineering and medical applications.Type: GrantFiled: August 14, 2001Date of Patent: January 13, 2009Assignee: Surface Logix, Inc.Inventors: Olivier Schueller, Enoch Kim, George Whitesides
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Patent number: 7439056Abstract: Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.Type: GrantFiled: July 29, 2002Date of Patent: October 21, 2008Assignee: Surface Logix Inc.Inventors: David Duffy, Gregory Kirk, Stewart Campbell, Olivier Schueller, Melina Agosto, Enoch Kim
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Patent number: 7422651Abstract: A method for applying a pattern to a target surface includes the steps of applying a coating of membrane material over a selected portion of a substrate. The substrate imparts a pattern to the membrane material corresponding to a pattern to be applied to the target surface. A support member is positioned in contact with an outer portion of the membrane material. The support member has a higher rigidity than the membrane material. The method may also combine the steps of curing the membrane material to bond the support member to the membrane. When bonded to the membrane, the support member maintains at least a portion of the membrane in a substantially taut condition to prevent a portion of the membrane from folding onto itself. The membrane is then employed to impart the pattern to the target surface.Type: GrantFiled: December 14, 2004Date of Patent: September 9, 2008Assignee: Surface Logix Inc.Inventors: Aaron Raphel, Enoch Kim, Emanuele Ostuni, Gregory Kirk, Olivier Schueller
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Patent number: 7419823Abstract: A device for monitoring leukocyte migration is provided. The invention also provides a method of using the device to monitor leukocyte migration in the presence of physiological shear flow and therefore simulate physiological conditions of a blood vessel in vivo. The invention further provides a method of using the device to high-throughput screen a plurality of test agents. The present invention further provides a flexible assay system and numerous assays that can be used to test biological interactions and systems. Laminar flow gradients are employed that mimic gradient situations present in vivo.Type: GrantFiled: October 21, 2003Date of Patent: September 2, 2008Assignee: Surface Logix, Inc.Inventors: Gregory L. Kirk, Emanuele Ostuni, Enoch Kim, Olivier Schueller, Paul Sweetnam
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Patent number: 7374906Abstract: The present invention discloses a device for monitoring chemotaxis or chemoinvasion. The present invention further provides a flexible assay system and numerous assays that can be used to test biological interactions and systems. Laminar flow gradients are employed that mimic gradient situations present in vivo.Type: GrantFiled: October 21, 2003Date of Patent: May 20, 2008Assignee: Surface Logix, Inc.Inventors: Gregory L. Kirk, Emanuele Ostuni, Enoch Kim, Olivier Schueller, Paul Sweetnam
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Patent number: 7371563Abstract: Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.Type: GrantFiled: July 29, 2002Date of Patent: May 13, 2008Assignee: Surface Logix, Inc.Inventors: David Duffy, Gregory L. Kirk, Stewart Campbell, Olivier Schueller, Melina Amber Agosto, Enoch Kim
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Patent number: 7364899Abstract: The present invention discloses a device for monitoring haptotaxis including a housing defining a chamber. The chamber comprises: a first well region including at least one first well, the first well configured to receive a test agent therein and further including biomolecules immobilized therein; a second well region including at least one second well, the second well region configured to receive a sample comprising cells therein and further being horizontally offset with respect to the first well region in a test orientation of the device; and a channel region including at a least one channel connecting the first well region and the second well region with one another, the channel region further including biomolecules immobilized therein.Type: GrantFiled: March 15, 2002Date of Patent: April 29, 2008Assignee: Surface Logix Inc.Inventors: Gregory L. Kirk, Matthew Brown, Emanuele Ostuni, Enoch Kim, Bernardo D. Aumond, Olivier Schueller, Paul Sweetnam, Brian Benoit
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Patent number: 7351575Abstract: Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.Type: GrantFiled: July 29, 2002Date of Patent: April 1, 2008Assignee: Surface Logix, Inc.Inventors: David Duffy, Gregory L. Kirk, Stewart Campbell, Olivier Schueller, Melina Agosto
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Patent number: 7338613Abstract: An automated process for microcontact printing is provided, comprising the steps of providing a substrate and a stamp; automatically aligning the substrate and stamp so that the stamp is aligned relative to the substrate to impart a pattern to the substrate at a desired location and with a desired orientation on the substrate; applying an ink to the stamp, the ink including a molecular species adapted to form a self-assembling monolayer (SAM) on the substrate; contacting the stamp and the substrate; and separating the stamp from the substrate.Type: GrantFiled: September 10, 2001Date of Patent: March 4, 2008Assignee: Surface Logix, Inc.Inventors: Olivier J. A. Schueller, Amar Kendale