Patents Assigned to Susumu Seino
  • Sodium ion-driven chloride/bi-carbonate exchanger
    Publication number: 20040063125
    Abstract: The present invention discloses DNAs comprising nucleotide sequences set forth as SEQ ID NO:1 or NO:3 encoding Na+-driven Cl-/HCO3- exchanger, proteins comprising amino acid sequences set forth as SEQ ID NO:2 or NO:4, and their homologous proteins comprising an amino acid sequence having deletion, substitution, addition or insertion amino acids, which proteins, when expressed in a cell, functions as Na+-driven Cl-/HCO3- exchanger, and cells in which the proteins exogenously expressed.
    Type: Application
    Filed: August 14, 2003
    Publication date: April 1, 2004
    Applicants: JCR Pharmaceuticals Co., Ltd., Susumu SEINO
    Inventors: Susumu Seino, Hideki Yano, Changzheng Wang
  • Sodium ion-driven chloride /bi-carbonate exchanger
    Patent number: 6673899
    Abstract: The present invention discloses DNAs comprising nucleotide sequences set forth as SEQ ID NO:1 or NO:3 encoding Na+-driven Cl—/HCO3— exchanger, proteins comprising amino acid sequences set forth as SEQ ID NO:2 or NO:4, and their homologous proteins comprising an amino acid sequence having deletion, substitution, addition or insertion amino acids, which proteins, when expressed in a cell, functions as Na+-driven Cl—/HCO3— exchanger, and cells in which the proteins exogenously expressed.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: January 6, 2004
    Assignees: JCR Pharmaceuticals Co., Ltd., Susumu Seino
    Inventors: Susumu Seino, Hideki Yano, Changzheng Wang
  • Induction of insulin-producing cells
    Publication number: 20030219894
    Abstract: What is described is a method for preparation of insulin-producing cells from non-insulin-producing cells. Mammalian fetal hepatocytes or hepatic progenitor cells are used ad the non-insulin-producing cells, and the method comprises culturing the mammalian fetal hepatocytes or the hepatic progenitor cells with 1-50 mmol/L of nicotinamide and concurrently bringing about expression of the PDX-1 gene or the NeuroD gene in the mammalian fetal hepatocytes.
    Type: Application
    Filed: April 15, 2003
    Publication date: November 27, 2003
    Applicants: JCR Pharmaceuticals Co., Ltd., Susumu SEINO
    Inventors: Susumu Seino, Nobuko Ishizuka, Masaaki Okuno
  • Apt-sensitive potassium channel gene-defective animals
    Patent number: 6194634
    Abstract: A Kir6.2 gene-defective, non-human mammal, a mouse in particular, its tissues and cells are provided, wherein the ATP-sensitive potassium channel Kir6.2 gene, one of the subunits of KATP channels essential for insulin secretion by pancreatic &bgr;-cells, is lost from one or both of the allelic loci.
    Type: Grant
    Filed: December 17, 1998
    Date of Patent: February 27, 2001
    Assignees: JCR Pharmaceuticals Co., Ltd., Susumu Seino
    Inventors: Susumu Seino, Takashi Miki, Junichi Miyazaki
  • Ubiquitous ATP-sensitive potassium-channel genes
    Patent number: 5919692
    Abstract: The present invention provides novel ATP-sensitive potassium-channel proteins which are present ubiquitously in the living bodies of animals, and their genes.
    Type: Grant
    Filed: March 12, 1996
    Date of Patent: July 6, 1999
    Assignees: Susumu Seino, JCR Pharmaceuticals Co., Ltd.
    Inventors: Susumu Seino, Nobuya Inagaki
  • Nucleic acids encoding potassium-channel proteins
    Patent number: 5917027
    Abstract: The present invention provides DNAs of h.beta.IR and m.beta.IR, which are novel ATP-sensitive potassium channels being present specifically in the pancreatic cells, and proteins encoded by such DNAs, wherein by utilizing them, it is possible to produce said proteins in large quantities through the known genetic engineering techniques for use as a reagent in the research work as well as in the diagnosis and therapy for diabetes and other diseases.
    Type: Grant
    Filed: March 12, 1996
    Date of Patent: June 29, 1999
    Assignees: Susumu Seino, JCR Pharmaceuticals Co., Ltd.
    Inventors: Susumu Seino, Nobuya Inagaki