Patents Assigned to Symbiontics, Inc.
  • Targeted therapeutic proteins
    Publication number: 20050281805
    Abstract: Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.
    Type: Application
    Filed: November 3, 2004
    Publication date: December 22, 2005
    Applicant: Symbiontics, Inc.
    Inventors: Jonathan LeBowitz, Stephen Beverley, William Sly
  • Targeted therapeutic proteins
    Publication number: 20040006008
    Abstract: Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.
    Type: Application
    Filed: October 16, 2002
    Publication date: January 8, 2004
    Applicant: Symbiontics, Inc.
    Inventors: Jonathan H. LeBowitz, Stephen M. Beverley
  • Targeted therapeutic proteins
    Publication number: 20040005309
    Abstract: Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.
    Type: Application
    Filed: October 16, 2002
    Publication date: January 8, 2004
    Applicant: Symbiontics, Inc.
    Inventors: Jonathan H. LeBowitz, Stephen M. Beverley, William S. Sly
  • Subcellular targeting of therapeutic proteins
    Publication number: 20030082176
    Abstract: Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.
    Type: Application
    Filed: April 30, 2002
    Publication date: May 1, 2003
    Applicant: Symbiontics, Inc.
    Inventors: Jonathan H. LeBowitz, Stephen M. Beverley
  • Sustained delivery device and methods of making and using the same
    Patent number: 6410250
    Abstract: Disclosed herein are novel medical devices, particular well-suited for sustained delivery of therapeutically-significant substances. Also disclosed are methods of making and using these delivery devices. Using these devices and methods, the present invention teaches sustained, targeted and reversible delivery of immunostimulating agents, as well as therapeutic agents such as enzymes, hormones and neurotransmitters, to name but a few.
    Type: Grant
    Filed: November 29, 1999
    Date of Patent: June 25, 2002
    Assignee: Symbiontics, Inc.
    Inventors: Frederico J. Gueiros-Filho, Stephen M. Beverley, Dennis E. Vaccaro
  • Sustained delivery device comprising a Leishmania protozoa and methods of making and using the same
    Patent number: 6020144
    Abstract: Disclosed herein are novel medical devices, particular well-suited for sustained delivery of therapeutically-significant substances. Also disclosed are methods of making and using these delivery devices. Using these devices and methods the present invention teaches sustained, targeted and reversible delivery of immunostimulating agents, as well as therapeutic agents such as enzymes, hormones and neurotransmitters, to name but a few.
    Type: Grant
    Filed: October 23, 1996
    Date of Patent: February 1, 2000
    Assignees: Symbiontics, Inc., Presidents and Fellows of Harvard University
    Inventors: Frederico J. Gueiros-Filho, Stephen M. Beverley, Dennis E. Vaccaro