Patents Assigned to Synthasome, Inc.
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Patent number: 9820847Abstract: Synthetic structures for fibrous soft tissue repair include a polymeric fibrillar structure that exhibits mechanical properties of the human fibrous soft tissue.Type: GrantFiled: August 17, 2007Date of Patent: November 21, 2017Assignee: Synthasome Inc.Inventors: Anthony Ratcliffe, Andreas Kern
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Patent number: 9597430Abstract: Synthetic structures for soft tissue repair include a multi-layer planar fibrillar structure having layers which are intermittently secured to each other and which approximates mechanical properties comparable to those of soft tissue. In embodiments, the fibrillar structure possesses an intermittently secured edge portion secured by intermittent welds. In embodiments, the multi layer planar fibrillar structure includes a bioactive agent.Type: GrantFiled: July 31, 2009Date of Patent: March 21, 2017Assignee: Synthasome, Inc.Inventors: Anthony Ratcliffe, Andreas Kern, Mohammad Sotoudeh, Fatemeh Ratcliffe
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Patent number: 9216194Abstract: The present disclosure provides a biocompatible composite and method for its use in repairing tissue defects, including defects in cartilage. The biocompatible composite includes a fibrous polymeric component and a polymerizable agent, which is capable of forming the biocompatible composite in situ at the site of a tissue defect. In embodiments, the repair site at which the biocompatible composite is to be applied may be treated with a priming agent, permitting polymerization of the polymerizable agent to the tissue located at the repair site.Type: GrantFiled: August 19, 2014Date of Patent: December 22, 2015Assignee: Synthasome, Inc.Inventor: Anthony Ratcliffe
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Patent number: 8883182Abstract: The present invention provides a composition and method for the covalent binding of a hydrogel to an extracellular matrix (ECM). Therapeutic applications include tissue repair and delivery of drugs or cells.Type: GrantFiled: October 9, 2004Date of Patent: November 11, 2014Assignee: Synthasome, Inc.Inventors: Anthony Ratcliffe, Jennifer H. Elisseeff, Dongan Wang
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Patent number: 8864844Abstract: A tissue engineered construct made totally or in part from biocompatible materials and mammalian cells and/or cell products is provided. These constructs are useful in regenerating complex tissues such as bone, ligament and tendon, which may fabricated into medical devices suitable for use in the treatment of injuries and maladies such as rotator cuff injuries, periodontal disease and hernia.Type: GrantFiled: August 9, 2007Date of Patent: October 21, 2014Assignee: Synthasome, Inc.Inventors: Anthony Ratcliffe, Andreas Kern, Fatemeh Ratcliffe
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Patent number: 8808730Abstract: The present disclosure provides a biocompatible composite and method for its use in repairing tissue defects, including defects in cartilage. The biocompatible composite includes a fibrous polymeric component and a polymerizable agent, which is capable of forming the biocompatible composite in situ at the site of a tissue defect. In embodiments, the repair site at which the biocompatible composite is to be applied may be treated with a priming agent, permitting polymerization of the polymerizable agent to the tissue located at the repair site.Type: GrantFiled: November 5, 2013Date of Patent: August 19, 2014Assignee: Synthasome, Inc.Inventor: Anthony Ratcliffe
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Publication number: 20140065201Abstract: The present disclosure provides a biocompatible composite and method for its use in repairing tissue defects, including defects in cartilage. The biocompatible composite includes a fibrous polymeric component and a polymerizable agent, which is capable of forming the biocompatible composite in situ at the site of a tissue defect. In embodiments, the repair site at which the biocompatible composite is to be applied may be treated with a priming agent, permitting polymerization of the polymerizable agent to the tissue located at the repair site.Type: ApplicationFiled: November 5, 2013Publication date: March 6, 2014Applicant: Synthasome, Inc.Inventor: Anthony Ratcliffe
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Patent number: 8574620Abstract: The present disclosure provides a biocompatible composite and method for its use in repairing tissue defects, including defects in cartilage. The biocompatible composite includes a fibrous polymeric component and a polymerizable agent, which is capable of forming the biocompatible composite in situ at the site of a tissue defect. In embodiments, the repair site at which the biocompatible composite is to be applied may be treated with a priming agent, permitting polymerization of the polymerizable agent to the tissue located at the repair site.Type: GrantFiled: May 3, 2011Date of Patent: November 5, 2013Assignee: Synthasome, Inc.Inventor: Anthony Ratcliffe
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Publication number: 20110206634Abstract: The present disclosure provides a biocompatible composite and method for its use in repairing tissue defects, including defects in cartilage. The biocompatible composite includes a fibrous polymeric component and a polymerizable agent, which is capable of forming the biocompatible composite in situ at the site of a tissue defect. In embodiments, the repair site at which the biocompatible composite is to be applied may be treated with a priming agent, permitting polymerization of the polymerizable agent to the tissue located at the repair site.Type: ApplicationFiled: May 3, 2011Publication date: August 25, 2011Applicant: SYNTHASOME, INC.Inventor: Anthony Ratcliffe
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Patent number: 7935363Abstract: The present disclosure provides a biocompatible composite and method for its use in repairing tissue defects, including defects in cartilage. The biocompatible composite includes a fibrous polymeric component and a polymerizable agent, which is capable of forming the biocompatible composite in situ at the site of a tissue defect. In embodiments, the repair site at which the biocompatible composite is to be applied may be treated with a priming agent, permitting polymerization of the polymerizable agent to the tissue located at the repair site.Type: GrantFiled: December 12, 2006Date of Patent: May 3, 2011Assignee: Synthasome, Inc.Inventor: Anthony Ratcliffe
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Publication number: 20110082389Abstract: A measuring system may provide quantitative information relating to condition of cartilage. Negative pressure may be applied to cartilage to induce flow of fluid from or through the cartilage. A level of negative pressure needed to induce a particular flow of the fluid may be employed to provide a quantitative indicia of cartilage condition. An averaged level of negative pressure measured over a period of time may be used to calculate hydraulic resistance of the cartilage.Type: ApplicationFiled: October 6, 2010Publication date: April 7, 2011Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SYNTHASOME, INC.Inventors: WILLIAM JOSEPH McCARTY, PRIYA SUNDARAMURTHY, CARYN URBANCZYK, ATAL PATEL, JACOB HAHR, ROBERT L. SAH, MOHAMMAD SOTOUDEH, ANTHONY RATCLIFFE
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Patent number: 7897165Abstract: The present invention relates to the covalent binding of a hydrogel to an extracellular matrix (ECM). The integration of the hydrogel with the tissue is superior to that in previous techniques. Moreover, unlike previous techniques, the present invention does not require a photoinitiator. Potential therapeutic applications include tissue repair and delivery of drugs or cells. The ECM is first exposed, then treated with a priming agent. Then a polymerizable agent is added and crosslinked to the ECM. Two primary embodiments of methods are disclosed. In the first, the priming agent is an oxidizer which creates tyrosyl radicals in the ECM, which are then bound by acrylate groups in the polymerizable agent. In the second, the priming agent contains aldehydes which bind amino groups in the ECM.Type: GrantFiled: March 7, 2006Date of Patent: March 1, 2011Assignee: Synthasome, Inc.Inventors: Jennifer Elisseeff, Dong-an Wang, Anthony Ratcliffe
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Patent number: 7862831Abstract: The present invention relates to the covalent binding of a hydrogel to an extracellular matrix (ECM). The integration of the hydrogel with the tissue is superior to that in previous techniques. Moreover, unlike previous techniques, the present invention does not require a photoinitiator. Potential therapeutic applications include tissue repair and delivery of drugs or cells. The ECM is first exposed, then treated with a priming agent. Then a polymerizable agent is added and crosslinked to the ECM. Two primary embodiments of methods are disclosed. In the first, the priming agent is an oxidizer which creates tyrosyl radicals in the ECM, which are then bound by acrylate groups in the polymerizable agent. In the second, the priming agent contains aldehydes which bind amino groups in the ECM.Type: GrantFiled: October 9, 2003Date of Patent: January 4, 2011Assignee: Synthasome, Inc.Inventors: Dongan Wang, Anthony Ratcliffe, Jennifer H. Elisseeff