Abstract: A method for resolving racemic mixtures of compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof that includes the steps of reacting the OR.sub.3 group of either compound with an esterifying agent in the case where R.sub.3 is H or a lower alkyl group; sujecting the compound to the action of an esterase capable of preferentially hydrolyzing either the (+) or (-) enantiomeric form of the compound; and separating the unhydrolyzed compound from the hydrolyzed compound.
Type:
Grant
Filed:
May 14, 1990
Date of Patent:
July 14, 1992
Assignee:
Synthetech, Inc.
Inventors:
Charles R. Eck, Paul C. Ahrens, Rae M. Saltzstein
Abstract: A process for forming a dipeptide which is substantially free of solid dipeptide-amino acid adduct by reacting the amino acid reactants in the presence of a polyol.
Abstract: This invention concerns a process for the recovery and purification of L-phenylalanine from a reaction mixture containing L-phenylalanine and contaminants.
Type:
Grant
Filed:
August 6, 1986
Date of Patent:
March 15, 1988
Assignee:
Synthetech, Inc.
Inventors:
David L. Evans, Roberta L. Thimmig, Robert C. Koltz