Abstract: A quantum computing transducer having a dense, tunable superconducting metamaterial transmission line (SMTL) spectrum that can resonantly enhance sideband scattering. The resonant enhancement of scattering boosts the scattering rate, and hence also the microwave-to-optical-interface (MOQI) transduction efficiency. Moreover, the integration of mechanical elements with the SMTL to realize the MOQI yields a platform that can be readily interfaced on chip, such as in an integrated circuit, with superconducting-qubit architectures to facilitate the local implementation of two of the essential functionalities required for a quantum repeater, i.e., data egress/ingress and a quantum processing module.

Abstract: A system configured to characterize a ratio of contributors to a DNA mixture within a sample, the system including: a sample preparation module configured to generate initial data about the DNA mixture within the sample; a processor comprising a ratio of contributors determination module configured to: (i) receive the generated initial data; (ii) analyze the generated initial data to determine the ratio of contributors to the DNA mixture within the sample; and an output device configured to receive the determined ratio of contributors from the processor, and further configured to output information about the received determined ratio of contributors.

Abstract: A metallo-dielectric waveguide array used as an encapsulation material for silicon solar cells. The array is produced through light-induced self-writing combined with in situ photochemical synthesis of silver nanoparticles. Each waveguide comprises a cylindrical core consisting of a high refractive index polymer and silver nanoparticles homogeneously dispersed in its medium, all of which are surrounded by a low refractive index common cladding. These waveguide array films are processed directly over a silicon solar cell.

Abstract: Disclosed herein are methods and compositions useful in the treatment and/or prevention of a disease or indication associated with accumulation of a bisretinoid, for example A2E. In many embodiments, the disclosed methods and compositions are useful in treating an eye disease, for example macular degeneration.

Abstract: The use of lipids in the taper junction or other metal on metal interface of a modular orthopedic implant to prevent fretting corrosion and increase the pull off load. The incorporation of lipids or a lipid-like substrate within the taper junction increases the onset load and decreases the amount of corrosion. The incorporation of lipids also increases the pull-off load necessary to separate the head from the neck. As a result, the use of lipids in the taper junction of an orthopedic implant should reduce the need for revisions of implants, such as such as knee and hip replacements, which are often needed because of fretting corrosion.

Abstract: A communication system that minimizes the transmission of pilot symbols while ensuring real-time channel tracking and symbol detection. The system employs a multiple-input multiple-output (MIMO) transmitter-receiver pair where there are many more receive antennas than transmit antennas. Communication occurs over a wide band RF channel via orthogonal frequency division multiplexing (OFDM) that employs a large number of sub-carriers.

Abstract: A micro environmental control system that can remove or add 30W from or to the near range personal microenvironment of a user. For cooling, the ?X uses a micro vapor compression system during the un-occupied period to freeze a phase-change-material in a thermal storage module. A fan then moves air over the phase-change-material to deliver cooled air. Heating is delivered by a small electric heater integrated into a condensing unit. The resulting system is inexpensive to build and uses a limited amount of energy.

Abstract: An integrated guidance and feedback control scheme for steering an underactuated vehicle through desired waypoints in three-dimensional space. The guidance and control algorithm takes as an input the desired trajectory for the translational motion that passes through the given waypoints, and autonomously generates the desired trajectory for the attitude based on the desired thrust direction to achieve the translational motion trajectory. A feedback control law is obtained to steer the underactuated vehicle towards the desired trajectories in translation and rotation.

Abstract: The present disclosure provides compositions that inhibit the SH2-containing inositol 5?-phosphatase (SHIP), as well as methods using such compositions for use in treating or ameliorating the effects of a medical condition in a subject.

Abstract: A system and method for determining the pH of tissue in vivo. A Raman spectrometer is used to collect Raman spectra from the target tissue. The Raman spectra are baseline subtracted and assessed to determine the concentration of HPO4?2 and H2PO4?1 for the purposes of calculating the pH. The approach was validate in vitro using PBS solutions of known pH. The approach was confirmed in vivo using rat and swine models by probing the immediate vicinity of a contusive spinal cord injury (SCI) in the first minutes and hours after injury. Using a dynamic analysis and the Henderson-Hasselbalch equation, the average of (N=12) noninvasive Raman-based pH measurements of CSF was 7.073±0.156 and at >95% confidence there is no statistically significant difference between the Raman-based and the physically sampled results.

Abstract: A system and method for automated detection of figure element reuse. The system can receive articles or other publications from a user input or an automated input. The system then extracts images from the articles and compares them to reference images from a historical database. The comparison and detection of matches occurs via a copy-move detection algorithm implemented by a processor of the system. The processor first locates and extracts keypoints from a submission image and finds matches between those keypoints and the keypoints from a reference image using a near neighbor algorithm. The matches are clustered and the clusters are compared for keypoint matching. Matched clusters are further compared for detectable transformations. The processor may additionally implement natural language processing to filter matches based on the context of the use of the submission image in the submission and a patch detector for removing false positive features.

Abstract: The present invention relates to the digestion of peptides by pancreatic proteases and, more specifically, to compositions and methods for protecting against protease digestion.

Abstract: A non-catalytic microcombustion based FFC for the direct use of hydrocarbons for power generation. The potential for high FFC performance (450 mW·cm?2 power density and 50% fuel utilization) in propane/air microcombustion exhaust was demonstrated. The micro flow reactor was used as a fuel reformer for equivalence ratios from 1-5.5. Soot formation in the micro flow reactor was not observed at equivalence ratios from 1 to 5.5 and maximum wall temperatures ranging from 750 to 900° C. H2 and CO concentrations in the exhaust were found to have a strong temperature dependence that varies with the maximum wall temperature and the local flame temperature.

Abstract: A variety of polymeric composites with tunable mechanical stiffness and electrical conductivity are claimed herein. For example, the composite may have an elastomeric matrix, a plurality of tunable particles, and a plurality of conductive fibers embedded in the matrix. The composites may also be a tunable foam matrix and an elastomeric matrix. In some embodiments, the composites are a low melting point alloy (LMPA) foam infiltrated by an elastomer, whose stiffness can be tuned by more than two orders of magnitude through external heating. In other embodiments, the composite may be a conductive particle-fiber-matrix three-component composite capable of changing its elastic rigidity rapidly and reversibly when powered with electrical current.

Abstract: A method for the avoidance of side effects associated with glucagon-like peptide-1 receptor (GLP-1R) agonists through vitamin B12 conjugation prior to administration. Vitamin B12 may be bound to a GLP-1R agonist, such as exendin-4 (Ex4), to provide enhanced proteolytic stability while retaining GLP-1R agonism. The conjugate (B12-Ex4) also improves glucose tolerance without producing anorexia and malaise. A GLP-1R agonist that is resistant to DPP-IV degradation and does not penetrate readily into the CNS, but retains the enhanced pharmacokinetic and pharmacodynamic profile on pancreatic ?-cells provide a pharmacological tool for glycemic control in type 2 diabetes mellitus (T2DM) patients without eliciting unwanted hypophagia and nausea.

Abstract: The present invention describes the use of nanoparticle interfaces to chemically process solid nanomaterials into ones with tailorable core-void-shell architectures. The internal void sizes are proportional to the nanoparticle size, the shell thickness and composition, and can be either symmetric or asymmetric depending on the nature of the interface, each of which is controlled by the process of making.

Abstract: Two peptides that can selectively bind to SEVI and block the enhanced infectivity that results from the interaction of SEVI with HIV. The two peptides comprise the amino acid sequences FEEIVQEIEDFLENLV (SEQ. ID NO: 1) and GIGAVLEVLTTGLPALISWIEEEEQQ (SEQ. ID. NO: 2). The peptides may be administered topically, either alone or in combination with other prophylactics, agents, etc.

Abstract: A system configured to characterize the probability of any allele dropout in the sequence of DNA extracted from a sample. The system includes a sample preparation module that can generate sequence data about any DNA within the sample, a processor that is programmed to receive the sequence data and determine the probability of allelic dropout in the sequence data, and an output device that provides the determination of allele dropout to a user of the system.

Abstract: A micro-tubular flame assisted fuel cell (mT FFC) integrated with a rich-burn, quick-mix, lean-burn (RQL) combustor for reduced NOx. Fuel and oxidant pass into a first-stage, fuel-rich combustion chamber. The exhaust products pass to the fuel cell for electrochemical conversion. Any remaining fuel is quickly mixed in a jet of oxidant to reduce temperature gradients and NOx formation in a second stage, fuel-lean combustion chamber. Preheating of the fuel, and different oxidant streams, is possible via heat exchangers in the fuel-rich and fuel-lean combustion chambers.

Abstract: A system that provides intent-oriented browsing powered by machine learning and crowdsourcing. The system allows users to enter their intents, which are then assigned to target pages via supervised learning models based on hyperlinks and contributions made by other users. The system has a prediction server that is programmed to receive hyperlinks from a website and return target hyperlinks based on known intent, a user interface for inputting user intent, and a browser programmed to connect to the intent repository and to the prediction server via a user script. The list of supported intents can grow over time based on correct page marks for intent-page mappings as well as via continuous training of machine learning models.