Abstract: The present invention provides a method for decreasing the level of methylation of Oct4 promoter in a target cell, comprising transfecting the target cell with the combination of Oct4 cDNA and SirT1 cDNA. The invention also provides a method for inducing cytoprotective responses of a target cell, comprising transfecting the target cell with the combination of Oct4 cDNA and SirT1 cDNA. The invention further provides a pharmaceutical composition comprising Oct4 cDNA and SirT1 cDNA, or a polynucleotide comprising Oct4 cDNA and SirT1 cDNA.

Abstract: The present invention pertains to a new approach for the treatment of infectious and malignant diseases. The present invention provides new DNA and protein vaccines for the treatment of infectious and malignant diseases through enhancing immune response.

Abstract: A method for delineation of characteristic points in an electrocardiogram signal includes the steps of: (a) processing the electrocardiogram signal to obtain at least one multiscale differential operator wavelet transform thereof; and (b) locating at least one characteristic point in at least one wave segment of the electrocardiogram signal based on the at least one multiscale differential operator wavelet transform.

Abstract: The present invention is based on the findings that a novel function for miR142-3p in the regulation of Sox2, adenylyl cyclase 9 (AC9), and CD133 expressions, and consequently the overall stemness of recurrent GBM cells as well as CSCs, and that miR142-3p modulated tumor-initiating properties in recurrent GBM. The present invention consequently supports the development of novel miRNA-based strategies for brain tumor treatment.

Abstract: Disclosed herein is a controlled release particle comprising a therapeutically effective amount of acid fibroblast growth factor (aFGF), entrapped by a particle composed by a biocompatible anionic biopolymer capable of binding to aFGF, and a cationic polymer. The method for manufacturing the controlled release particle and the method of using the particle for treating nervous injury are also provided.

Abstract: The invention relates to a device for selecting stem cells with a serum free medium for amplification of stem cells. The invention also relates to a method of treating or preventing diseases caused by cancer-related stem cells. The invention further provides a method of enhancing radiosensitivity of cancer-related stem cells comprising radiotherapy with resveratrol, and the cancer-related stem cell has stronger drug resistance. The present invention further provides that resveratrol promotes differentiation and inhibits teratoma/tumor formation in induced pluripotent stem cells (iPS) and embryonic stem cells.

Abstract: The invention provides a method of functionally connecting a portion of the peripheral nervous system of a vertebrate to a portion of the central or peripheral nervous system of said vertebrate, comprising the steps of bringing the portion of the peripheral nervous system and the portion of the central or peripheral nervous system close to each other, applying to the gap between the two portions a fibrin glue mixture comprising a growth factor, fibrinogen, aprotinin and divalent calcium ions so that the fibrin glue mixture is simultaneously in contact with the two portions, and forming an attachment between the portion of the peripheral nervous system and the portion of the central or peripheral nervous system of said vertebrate.

Abstract: A composite comprising a stem cell; a biodegradable layer, which can provide an environment for the stem cell to grow and to differentiate, and; a N-isopropylacrylamide (NIPAAm), which can polymerize with the biodegradable layer and possess the temperature-responsive character for easy stripping. The present invention further provides a method for treating a patient with a skin defect, consisting of (a) providing said patient with a composite consisting of a N-isopropylacrylamide (NIPAAm) layer polymerized with a biodegradable layer containing gelatin and a layer of polypropylene (PP) non-woven, wherein a bone marrow derived mononuclear cell with CD45 negative and glycophorin A negative is cultivating on the biodegradable layer; (b) covering said composite on the skin defect of the patient; and (c) treating the composite with water below 25° C. to strip off the layer of polypropylene (PP) non-woven.

Abstract: The invention relates to modular hip joint prosthesis and an assembling method thereof. The modular hip joint prosthesis includes a stem component, a proximal body module and lock component. The proximal body module assembles with the stem component and includes a first curved surface component and a second curved surface, wherein the radius of curvature of the first curved surface component is different from the radius of curvature of the second curved surface component. The lock component is used to encase the first curved surface component and the second curved surface for locking up both components.

Abstract: The present invention provides a method of treating neural injury, e.g., spinal cord injury (SCI), or enhancing recovery from the neural injury with silymarin or silybin.

Abstract: An anti-subsidence dynamic hip screw comprises of a barrel having a connection portion and a tube-type extending portion angled a predetermined angle with the connection portion, and a first long groove and a first limit portion disposed at the inner wall of the extending portion respectively; a lag screw having an inside end disposed threading screw at its outer edge and a outside end with a predetermined length passed through in the extending portion by the way of reciprocation; a second long groove and a second limit portion disposed at the lag screw respectively related to the first long groove and the first limit portion, each first limit portion and second limit portion used for preventing the lag screw from rotating inside the extending portion; a blade piece with a predetermined length simultaneously passed through and retained in the first long groove and the related second long groove; a compressing screw having an inside end screwed with the outside end of the lag screw and an outside end retained

Abstract: A detachable vaginal mold is provided. The detachable vaginal mold includes a main body, a minor part, and a jointing design formed between the main body and the minor part for connecting the main body to the minor part. The jointing design is one selected from a group consisting of a dentation design, a mortise design, a screw design, a mitre design, a fastener design, and a combination thereof.

Abstract: The present invention provides an oligonucleotide for amplifying a nucleic acid of human cytomegalovirus and a kit for detecting human cytomegalovirus. The present invention also provides an oligonucleotide for identifying a nucleic acid of human cytomegalovirus. The present invention further provides a method of detecting human cytomegalovirus in an individual.

Abstract: The invention relates to a device for selecting stem cells with a serum free medium for amplification of stem cells. The invention also relates to a method of treating or preventing diseases caused by cancer-related stem cells. The invention further provides a method of enhancing radiosensitivity of cancer-related stem cells comprising radiotherapy with resveratrol, and the cancer-related stem cell has stronger drug resistance.

Abstract: A method for promoting a differentiation of stem cells into insulin producing cells is provided. The method includes steps of suspending the stem cells in a first culture medium, aggregating the stem cells to form a cell pellet, and culturing the cell pellet in a second culture medium to promote the differentiation of the stem cells of the cell pellet into the insulin producing cells.

Abstract: The present invention relates to the system and methods for screening or analyzing targets.

Abstract: A composite comprising a stem cell; a biodegradable layer, which can provide an environment for the stem cell to grow and to differentiate, and; a N-isopropylacrylamide (NIPAAm), which can polymerize with the biodegradable layer and possess the temperature-responsive character for easy stripping. This invention also provides a method of treating a subject with a skin defect by covering the composite of the present invention on the skin defect of the subject in need of such treatment. Furthermore, using this composite with different growth factors, stem cells can be induced to differentiate into skin-related, neuronal cells, neuron, and insulin-positive cells in biodegradable scaffolds as well as transplanted graft. Finally, this invention also provides a quick and convenient method of monitoring cell growth or tissue engineering in an animal.

Abstract: The present invention provides methods and kits for detecting human cytomegalovirus. The present invention also provides oligonucleotides for detecting human cytomegalovirus.

Abstract: The tail suspension test apparatus for detecting a struggling state of an animal by suspending a tail of the animal includes an optical mouse, an opaque piece located within a sensing range of the optical mouse, and a fixing device connected with the opaque piece for fixing the tail of the animal. When the animal is struggling, an action of the opaque piece is induced and detected by the optical mouse.

Abstract: A nutraceutical composition containing 0.01-99% by weight polysaccharides enriched from an extract of beans of Glycine max (L.) Merr. Also disclosed are a method of enriching polysaccharides from pulverized beans of Glycine max (L.) Merr.; a polysaccharide having a backbone of ?-(1,6)-linked glucose residues, and one or more galactose or mannose residues are bonded to the C-3 or C-4 position of one or more of the glucose residues by a (1,3)- or a (1,4)-linkage; and a method of treating a subject with such polysaccharides to increase blood cell counts.