Patents Assigned to Takeda Chemical Industries, Inc.
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Patent number: 4959362Abstract: An ascorbic acid derivative of the formula: ##STR1## wherein R.sup.1 is organic residue having molecular weight of from 15 to 700, R.sup.2 is hydrogen or hydroxyl, R.sup.3 is hydrogen, acyl, optionally substituted phosphono or sulfo, and R.sup.3 and hydroxyl or R.sup.2 may form acetal residue or ketal residue, and a salt thereof are provided.The compound [I] and salts thereof have antioxidant activity and excellent prophylactic and improving actions on disorders of circulatory functions, and they are usefule as antioxidant agent for food and as agents of prophylaxis and improvement of circulatory functional disorders.Type: GrantFiled: September 19, 1988Date of Patent: September 25, 1990Assignee: Takeda Chemical Industries, Inc.Inventors: Shinji Terao, Minoru Hirata
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Patent number: 4831111Abstract: A cross-linked resin produced by the reaction of a bis(2-oxazoline) compound with a dicarboxylic acid anhydride, and optionally also with at least one selected from the group consisting of a dicarboxylic acid, a hydroxy-carboxylic acid, a diol and water, in the presence of at least one catalyst selected from the group consisting of an organic phosphorous acid ester, an organic phosphonous acid ester and an inorganic salt at an elevated temperature. The cross-linked resin has a high mechanical strength and a high resistance to organic solvents.The resin composition comprising the cross-linked resin and reinforcements and/or fillers combined therewith has outstanding heat-resistance and mechanical properties.Type: GrantFiled: May 18, 1988Date of Patent: May 16, 1989Assignee: Takeda Chemical Industries, Inc.Inventors: Yasuo Sano, Yasuhiro Morisue, Kiyoshi Komiya, Yoshimasa Nakamura
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Patent number: 4701559Abstract: A compound of the formula: ##STR1## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms optionally substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or an optionally substituted phenyl group, or a cyclic hydrocarbon group having 3 to 7 carbon atoms optionally substituted by hydroxyl, B is hydrogen or hydroxyl, and their production and use.These compounds exhibit excellent inhibitory activity against .alpha.-glucoside hydrolase, thus are useful for hyperglycemic symptoms and various disorders caused by hyperglycemia.Type: GrantFiled: December 28, 1981Date of Patent: October 20, 1987Assignee: Takeda Chemical Industries, Inc.Inventors: Satoshi Horii, Yukihiko Kameda, Hiroshi Fukase
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Patent number: 4675430Abstract: 2-Alkanoyloxy-3-(N-octadecylcarbamoyloxy)propyl trimethylammonioethyl phosphates and a salt thereof exhibit inhibitory activity against multiplication of tumor cells, and are useful as an antitumor agent.Type: GrantFiled: June 18, 1986Date of Patent: June 23, 1987Assignee: Takeda Chemical Industries, Inc.Inventors: Keizo Inoue, Hiroaki Nomura, Tetsuya Okutani
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Patent number: 4613652Abstract: A curable resin composition which comprises (1) a copolymer composed of an aminoalkyl acrylate and/or aminoalkyl methacrylate and an ethylenically unsaturated monomer being formulated with (2) a compound having at least two acryloyl groups in the molecule.The composition can be cured at low temperatures in the range of ordinary temperature to 120.degree. C., and therefore advantageously used for the formation of coating films in the application fields, such as plastics, wood and concrete, where heat treatment cannot be performed. Also, the composition which exhibits excellent adherence toward various kinds of substrates can be used as adhesives and different kinds of primers, as well. Furthermore, the composition can provide coating films that excel in terms of water resistance, weathering resistance and solvent resistance, and therefore be utilized for overpaints, etc.Type: GrantFiled: June 7, 1985Date of Patent: September 23, 1986Assignee: Takeda Chemical Industries, Inc.Inventors: Takeo Nakayama, Kimiya Fujinami, Takurou Sakamoto, Fumihiro Doura
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Patent number: 4612321Abstract: Novel compounds of the formula: ##STR1## wherein R.sup.1 stands for an optionally substituted alkyl group, alkenyl group, aryl group, aralkyl group, cycloalkyl group, heterocyclic group having carbon as the bonding hand or amino group, R.sup.2 stands for a pyridyl group which may be substituted with alkyl group, and R.sup.3 stands for an optionally substituted aryl group or salts thereof, have analgesic, anti-piretic, anti-inflammatory and anti-ulcer actions, and can be administered to mammals for the therapy of pain, inflammatory diseases, rheumatic chronic diseases.Type: GrantFiled: September 5, 1984Date of Patent: September 16, 1986Assignee: Takeda Chemical Industries, Inc.Inventors: Shinji Terao, Yoshitaka Maki
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Patent number: 4576995Abstract: Disclosed is an adhesive for bonding an ethylene/vinyl alcohol copolymer and polystyrene, which comprises a modified ethylene/vinyl acetate copolymer obtained by graft-copolymerizing a styrenic vinyl monomer and an .alpha.,.beta.-unsaturated carboxylic acid to an ethylene/vinyl acetate copolymer. A laminated article having the said adhesive as an interlayer and production thereof are also disclosed. The laminated article shows strong resistance to delamination and excels in processability. Therefore, the laminate is valuable as a deep-draw forming material with enhanced gas barrier properties for a preservation rigid container for foods.Type: GrantFiled: July 19, 1984Date of Patent: March 18, 1986Assignee: Takeda Chemical Industries, Inc.Inventors: Masamitsu Nakabayashi, Yuzo Furukawa, Akira Tashiro
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Patent number: 4478894Abstract: Disclosed are a thermosetting polyurethane coating composition of one-pack type which comprises a product obtained by reacting (i) an isocyanate component having at least one oxadiazinetrione ring obtained by the reaction of bis(isocyanatomethyl)cyclohexane with carbon dioxide with (ii) a polyol component having a molecular weight of 400 to 50,000 at such a proportion as satisfying the relations: the number of hydroxyl group > the number of free isocyanate group and the number of oxadiazinetrione ring/(the number of hydroxyl group--the number of free isocyanate group)=0.1 to 10 and a process for producing the coating composition.The composition has excellent storage stability and the cured coatings have no problems of yellowing and pin-holes and are excellent in mechanical properties, chemical resistance and weather resistance.Type: GrantFiled: November 29, 1982Date of Patent: October 23, 1984Assignee: Takeda Chemical Industries, Inc.Inventors: Michio Tanaka, Yoshio Kamatani, Koji Nasu
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Patent number: 4443597Abstract: Polyisocyanates having oxadiazinetrione rings obtained by reacting bis(isocyanatomethyl)cyclohexane, an oligomer thereof, an adduct thereof or a mixture of them with carbon dioxide. Said polyisocyanates have excellent properties as raw materials for the production of polyurethanes, because of their higher reactivity at lower temperature and better storage stability.Type: GrantFiled: November 30, 1982Date of Patent: April 17, 1984Assignee: Takeda Chemical Industries, Inc.Inventors: Yoshio Kamatani, Noriaki Fujita
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Patent number: 4424214Abstract: Pyrazolyl phosphates of the formula ##STR1## wherein R.sup.1 is alkyl, aralkyl, or phenyl which may optionally be substituted by halogen or lower alkyl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is hydrogen, halogen, nitro, lower alkyl or --COOR.sup.6 wherein R.sup.6 is lower alkyl; R.sup.4 is lower alkyl; R.sup.5 is lower alkylthio; and X is oxygen or sulfur, have marked insecticidal-acaricidal activity against household pests, plant pests and mites, without substantial toxicity to warm-blooded animals and fish.Type: GrantFiled: April 12, 1982Date of Patent: January 3, 1984Assignee: Takeda Chemical Industries, Inc.Inventors: Yoshiyuki Okada, Yasuo Sato
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Patent number: 4172891Abstract: A novel cephalosporin derivative of the formula: ##STR1## [wherein X is hydrogen, hydroxyl, acyloxy, alkoxy, carbamoyloxy, quaternary ammonium or a group of the formula --SR.sup.1 (where R.sup.1 is a nitrogen-containing heterocyclic group)] or a pharmaceutically acceptable salt or ester thereof is found to have potent antibiotic activity against various bacteria, particularly against gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis, Proteus morganii, Proteus rettgeri and Citrobacter freundii.Type: GrantFiled: March 31, 1977Date of Patent: October 30, 1979Assignee: Takeda Chemical Industries, Inc.Inventors: Mitsuo Numata, Masayoshi Yamaoka, Isao Minamida, Mitsuru Shiraishi, Tatsuo Nishimura
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Patent number: 3975538Abstract: New miticidal compounds of the formula ##SPC1##Wherein R represents lower alkyl or lower alkenyl, R.sup.1 and R.sup. 2 respectively represent lower alkyl and X represents oxygen or sulfur.Type: GrantFiled: June 16, 1975Date of Patent: August 17, 1976Assignee: Takeda Chemical Industries, Inc.Inventors: Toshiya Kamikado, Takashi Kuragano, Kazuo Konishi, Yasuo Sato, Masayoshi Nagano