Abstract: The invention relates to the use of Roflumilast, Roflumilast N-Oxide or a pharmaceutically acceptable salt of either for the treatment of pulmonary hypertension. The invention additionally relates to the use of Roflumilast, Roflumilast N-oxide or a pharmaceutically acceptable salt of either in combination with a PDE5 inhibitor or a pharmaceutically acceptable salt thereof for the treatment of pulmonary hypertension.
Type:
Grant
Filed:
April 12, 2006
Date of Patent:
February 11, 2014
Assignee:
Takeda GmbH
Inventors:
Rolf Beume, Armin Hatzelmann, Degenhard Marx, Christian Schudt, Hermann Tenor, Saadia Eddahibi, Serge Adnot
Abstract: Disclosed herein are salts of 6-heteroaryl substituted hexahydrophenanthridine PDE4 inhibiting compounds, which can be used in the pharmaceutical industry for the production of pharmaceutical compositions.
Type:
Application
Filed:
October 11, 2013
Publication date:
February 6, 2014
Applicant:
TAKEDA GMBH
Inventors:
Ulrich KAUTZ, Matthias WEBEL, Christian SCHEUFLER, Rolf-Peter HUMMEL
Abstract: A composition comprising: roflumilast having a purity of greater than or equal to 99% by weight, and N-(3,5-dichloropyrid-4-yl)-3-cyclopropylmethoxy-4-hydroxybenzamide present (relative to roflumilast) in an amount greater than zero and less than 0.1% by weight.
Type:
Grant
Filed:
April 10, 2013
Date of Patent:
December 31, 2013
Assignee:
Takeda GmbH
Inventors:
Bernhard Kohl, Bernd Mueller, Walter Palosch
Abstract: A method for the treatment of chronic obstructive pulmonary disease (COPD), including administering to a patient suffering from COPD, a therapeutically effective amount of roflumilast having a purity of greater than or equal to 99% by weight, and N-(3,5-dichloropyrid-4-yl)-3-cyclopropylmethoxy-4-hydroxybenzamide present (relative to roflumilast) in an amount greater than zero and less than 0.1% by weight.
Type:
Grant
Filed:
April 10, 2013
Date of Patent:
December 10, 2013
Assignee:
Takeda GmbH
Inventors:
Bernhard Kohl, Bernd Mueller, Walter Palosch
Abstract: The present invention relates to a method of preparing a peptide comprising the amino acid sequence His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp (SEQ ID NO:1). In particular, the method comprises the steps of providing a first peptide fragment having a first protection group, which peptide fragment is conjugated to a support; providing a second peptide fragment having a second protection group; removing the first protection group from the first peptide fragment; and coupling the second peptide fragment to the N-terminally deprotected, support-conjugated first peptide fragment. The present invention further relates to a method of preparing a pharmaceutical composition containing said peptide.
Abstract: The application relates to specific combinations of Roflumilast and/or Roflumilast N-Oxide and a PPAR-agonist, as well as their use in the treatment of diabetes mellitus type 2.
Abstract: The present invention relates to a sterile aqueous suspension containing ciclesonide, a microgel and a water soluble ionic polymer. The present invention provides a sterile aqueous suspension in which ciclesonide is dispersed homogeneously over a long period of time.
Abstract: A device and system for delivering an aerosol to a patient on ventilatory support comprise a contact component 10 to be positioned in contact with a respiratory organ. The contact component 10 comprises a lumen 18a, 20a, 24 through which breathing gas and an aerosol are delivered to lungs of a patient.
Type:
Application
Filed:
August 8, 2011
Publication date:
June 20, 2013
Applicant:
TAKEDA GMBH
Inventors:
Daniela Rahmel, Friedemann Taut, Christian De Muynck, Peter Iwatschenko, Wolfgang Koch, Gerhard Pohlmann, Horst Windt
Abstract: The invention relates to an oral administration form for pyridin-2-ylmethylsulfinyl-1H-benzimidazoles and their salts, which comprises the active compound together with tablet disintegrants and is provided with a film coating customary per se for sustained-release compositions.
Abstract: A compliance monitor (20) is attachable to or forms part of a drug delivery device, such as an inhaler (2). The monitor comprises a flexible portion (38) to enable a switch which is actuated by a user when delivering a dose of medicament. The monitor further comprises a sensor for sensing whether the device is properly positioned in contact with or relative to the user's body for administration of the medicament. For example, where the device is an inhaler and the sensor a temperature sensor, temperature variations caused by insertion of an inhaler mouthpiece into the user's mouth indicate whether the dose has been delivered into the patient's mouth. A memory in the compliance monitor stores a compliance record indicating whether or not the device was properly positioned each time a dose was delivered.
Type:
Grant
Filed:
September 22, 2004
Date of Patent:
June 18, 2013
Assignee:
Takeda GmbH
Inventors:
Roberto Jongejan, Antje-Henriette Fink-Wagner, Christopher Ferris
Abstract: The invention relates to aerosolized and humidified particles comprising a therapeutically active substance which can be obtained by suspending dry inhalable particles in a carrier gas, adding water vapor and causing condensation of water on the particles. The invention further relates to methods to generate these particles, and apparatus useful to carry out such methods.
Type:
Application
Filed:
August 22, 2011
Publication date:
June 6, 2013
Applicant:
TAKEDA GMBH
Inventors:
Daniela Rahmel, Friedemann Taut, Christian De Muynck, Markus Rast, Peter Iwatschenko, Gerhard Pohlmann, Wolfgang Koch, Horst Windt
Abstract: Compounds of the formula Ia***** in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors, useful in the treatment of psoriasis.