Abstract: Methods of purifying virus-like particles (VLPs) that are substantially free of process contaminants and infectious agents. The methods incorporate, for example, low-pH treatment during harvest and/or inactivation by a solvent and/or detergent during VLP capture.
Abstract: The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.
Type:
Grant
Filed:
June 16, 2010
Date of Patent:
April 30, 2013
Assignee:
Takeda Vaccines (Montana), Inc.
Inventors:
Charles Richardson, Thomas S. Vedvick, Thomas R. Foubert, William T. Tino