Patents Assigned to TALIS BIOMEDICAL CORPORATION
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Patent number: 11998883Abstract: This disclosure relates to a magnetic mixing apparatus that mixes a sample contained in a mixing chamber using a stir bar, while minimizing the amount of contact between the stir bar and walls of the mixing chamber. In one aspect, the apparatus comprises a ferromagnetic stir bar contained in the mixing chamber, and a driving magnet and a driven magnet located on opposite sides of the mixing chamber. The driving magnet, the driven magnet, and the ferromagnetic stir bar are each capable of rotating about a respective axis. The driving magnet, the driven magnet, and the ferromagnetic stir bar are magnetically coupled such that rotation of the driving magnet induces rotation of the driven magnet and rotation of the driving magnet and the driven magnet induce rotation of the ferromagnetic stir bar. In some embodiments, rotation of the ferromagnetic stir bar within the mixing chamber mixes the sample contained within the mixing chamber.Type: GrantFiled: September 12, 2018Date of Patent: June 4, 2024Assignee: Talis Biomedical CorporationInventors: Thomas H. Cauley, III, David A. Rolfe
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Patent number: 11986299Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.Type: GrantFiled: November 2, 2020Date of Patent: May 21, 2024Assignee: Talis Biomedical CorporationInventors: Sayeed Andeshmand, Thomas H. Cauley, III, John Dixon, David Glade, Hédia Maamar, Michael John McAdams, Dzam-Si Jesse Ng, David Alexander Rolfe
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Patent number: 11920700Abstract: Rotary valves and methods of using, manufacturing, and storing the same are provided herein. The rotary valve includes a rotor and a stator, biased toward one another to form a fluid tight seal. In some implementations, the rotor comprises an integrated flow channel containing a porous solid support. Frequently, the interface between rotor and stator is made fluid-tight using a gasket. Some implementations of the rotary valve include a displaceable spacer to prevent the gasket from sealing against at least one of the rotor and stator prior to operation, wherein when the spacer is displaced, the gasket seals the rotor and stator together in a fluid-tight manner.Type: GrantFiled: February 15, 2019Date of Patent: March 5, 2024Assignee: Talis Biomedical CorporationInventors: Sayeed Andeshmand, Thomas H. Cauley, III, John Dixon
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Patent number: 11891662Abstract: Disclosed herein are primers and probes related to the detection of beta actin [Homo sapiens (human)] via nucleic acid amplification testing (NAAT), for example to amplify and determine the presence of ?-actin present in test samples. Specifically, the present disclosure describes primers and probes that bind to the beta actin gene for detection via loop mediated isothermal amplification (LAMP) and molecular beacon hybridization.Type: GrantFiled: December 2, 2019Date of Patent: February 6, 2024Assignee: Talis Biomedical CorporationInventors: Jason M. Casolari, Xuewen Jiang, Hédia Maamar
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Patent number: 11633736Abstract: This disclosure relates to an apparatus for simultaneously filling a plurality of sample chambers. In one aspect, the apparatus comprises a common fluid source and a plurality of independent, continuous fluidic pathways. Each independent, continuous fluidic pathway comprises a sample chamber and a pneumatic compartment. The sample chamber is connected to the common fluid source, and the pneumatic compartment is connected to the sample chamber. The sample chamber comprises, in part, an assay chamber. The assay chamber comprises a monolithic substrate and a plug having optically transmissive properties. In some embodiments, the assay chamber contains a magnetic mixing element. In some embodiments, the assay chamber is a double tapered chamber. In some embodiments, a ratio of a volume of the sample chamber to a volume of the pneumatic compartment is substantially equivalent for each fluidic pathway of the plurality of fluidic pathways.Type: GrantFiled: March 22, 2019Date of Patent: April 25, 2023Assignee: TALIS BIOMEDICAL CORPORATIONInventor: Thomas H. Cauley, III
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Publication number: 20230002826Abstract: Disclosed herein are primers and probes related to the detection of beta actin [Homo sapiens (human)] via nucleic acid amplification testing (NAAT), for example to amplify and determine the presence of ?-actin present in test samples. Specifically, the present disclosure describes primers and probes that bind to the beta actin gene for detection via loop mediated isothermal amplification (LAMP) and molecular beacon hybridization.Type: ApplicationFiled: December 1, 2020Publication date: January 5, 2023Applicant: TALIS BIOMEDICAL CORPORATIONInventors: Jason M. CASOLARI, Xuewen JIANG, Hedia MAAMAR
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Patent number: 11542545Abstract: Disclosed herein are methods and devices for rapid assessment of whether a microorganism present in a sample is susceptible or resistant to a treatment.Type: GrantFiled: November 5, 2015Date of Patent: January 3, 2023Assignees: California Institute of Technology, Talis Biomedical CorporationInventors: Rustem F. Ismagilov, Eugenia Khorosheva, Travis S. Schlappi, Matthew S. Curtis, Nathan G. Schoepp, Hedia Maamar, Feng Shen, Erik B. Jue
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Patent number: 11326214Abstract: The invention provides methods and compositions for the detection of Chlamydia trachomatis in a test sample. Its presence or absence in the sample is determined by nucleic acid based testing methods using primers and/or probes and or molecular beacons that bind to the 23S ribosomal genes or gene transcripts.Type: GrantFiled: September 11, 2019Date of Patent: May 10, 2022Assignee: Talis Biomedical CorporationInventors: Andrea Dedent, Matt Lee, Shuyuan Ma, Hedia Maamar
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Publication number: 20210331173Abstract: This disclosure relates to an apparatus for simultaneously filling a plurality of sample chambers. In one aspect, the apparatus comprises a common fluid source and a plurality of independent, continuous fluidic pathways. Each independent, continuous fluidic pathway comprises a sample chamber and a pneumatic compartment. The sample chamber is connected to the common fluid source, and the pneumatic compartment is connected to the sample chamber. The sample chamber comprises, in part, an assay chamber. The assay chamber comprises a monolithic substrate and a plug having optically transmissive properties. In some embodiments, the assay chamber contains a magnetic mixing element. In some embodiments, the assay chamber is a double tapered chamber. In some embodiments, a ratio of a volume of the sample chamber to a volume of the pneumatic compartment is substantially equivalent for each fluidic pathway of the plurality of fluidic pathways.Type: ApplicationFiled: March 22, 2019Publication date: October 28, 2021Applicant: TALIS BIOMEDICAL CORPORATIONInventor: Thomas H. CAULEY, III
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Patent number: 11047007Abstract: Disclosed herein are primers and probes related to the detection of SARS-CoV-2 via nucleic acid amplification testing (NAAT), for example to amplify and determine the presence of SARS-CoV-2 in test samples and/or to diagnose Covid-19. Specifically, the present disclosure describes primers and probes that bind to the N gene, ORF1ab, or E gene of SARS-CoV-2 coronavirus for detection via loop mediated isothermal amplification (LAMP) and molecular beacon hybridization.Type: GrantFiled: June 25, 2020Date of Patent: June 29, 2021Assignee: Talis Biomedical CorporationInventors: Nadya Andini, Kathy Chiu, Xuewen Jiang, Hédia Maamar
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Patent number: 11009150Abstract: Rotary valves and methods of using, manufacturing, and storing the same are provided herein. The rotary valve includes a rotor and a stator, biased toward one another to form a fluid tight seal. In some implementations, the rotor comprises an integrated flow channel containing a porous solid support. Frequently, the interface between rotor and stator is made fluid-tight using a gasket. Some implementations of the rotary valve include a displaceable spacer to prevent the gasket from sealing against at least one of the rotor and stator prior to operation, wherein when the spacer is displaced, the gasket seals the rotor and stator together in a fluid-tight manner.Type: GrantFiled: November 25, 2019Date of Patent: May 18, 2021Assignee: Talis Biomedical CorporationInventors: Thomas H. Cauley, III, John Dixon
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Patent number: 11008627Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.Type: GrantFiled: October 16, 2019Date of Patent: May 18, 2021Assignee: Talis Biomedical CorporationInventors: Sayeed Andeshmand, Thomas H. Cauley, III, John Dixon, David Glade, Hédia Maamar, Michael John McAdams, Dzam-Si Jesse Ng, David Alexander Rolfe
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Publication number: 20210116049Abstract: Rotary valves and methods of using, manufacturing, and storing the same are provided herein. The rotary valve includes a rotor and a stator, biased toward one another to form a fluid tight seal. In some implementations, the rotor comprises an integrated flow channel containing a porous solid support. Frequently, the interface between rotor and stator is made fluid-tight using a gasket. Some implementations of the rotary valve include a displaceable spacer to prevent the gasket from sealing against at least one of the rotor and stator prior to operation, wherein when the spacer is displaced, the gasket seals the rotor and stator together in a fluid-tight manner.Type: ApplicationFiled: February 15, 2019Publication date: April 22, 2021Applicant: Talis BioMedical CorporationInventors: Sayeed ANDESHMAND, Thomas H. CAULEY, III, John DIXON
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Patent number: 10954572Abstract: Disclosed herein are primers and probes related to the detection of Neisseria gonorrhoeae via nucleic acid amplification testing (NAAT), for example to amplify and determine the presence of N. gonorrhoeae nucleic acids present in test samples. Specifically the present disclosure describes primers and probes that bind to Cytochrome C or ccpA gene of N. gonorrhoeae for detection via loop mediated isothermal amplification (LAMP) and molecular beacon hybridization.Type: GrantFiled: December 18, 2019Date of Patent: March 23, 2021Assignee: Talis Biomedical CorporationInventors: Andrea C. Dedent, Hedia Maamar, Dana Kelly Vanatta
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Publication number: 20210023560Abstract: This disclosure relates to an apparatus for simultaneously filling a plurality of sample chambers. In one aspect, the apparatus comprises a common fluid source and a plurality of independent, continuous fluidic pathways. Each independent, continuous fluidic pathway comprises a sample chamber and a pneumatic compartment. The sample chamber is connected to the common fluid source, and the pneumatic compartment is connected to the sample chamber. The sample chamber comprises, in part, an assay chamber. The assay chamber comprises a monolithic substrate and a plug having optically transmissive properties. In some embodiments, the assay chamber contains a magnetic mixing element. In some embodiments, the assay chamber is a double tapered chamber. In some embodiments, a ratio of a volume of the sample chamber to a volume of the pneumatic compartment is substantially equivalent for each fluidic pathway of the plurality of fluidic pathways.Type: ApplicationFiled: March 22, 2019Publication date: January 28, 2021Applicant: TALIS BIOMEDICAL CORPORATIONInventor: Thomas H. CAULEY, III
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Patent number: 10898895Abstract: This disclosure relates to an assembly for loading a sample liquid. The assembly comprises an entry port comprising an inlet and a gas vent, and a reservoir. The reservoir comprises a distal wall, a fin, and a continuous fluidic pathway. The fin comprises first and second surfaces and extends from the inlet towards the distal wall. The continuous fluidic pathway comprises a converging channel that is in fluidic communication with the inlet and is defined by the second surface of the fin, and a diverging channel that is defined by the first surface of the fin and is in fluidic communication with the gas vent. At a distal end of the fin, a width of the converging channel at most equals a width of the diverging channel, and the width of the converging channel at most equals a distance between the distal end of the fin and the distal wall.Type: GrantFiled: September 13, 2018Date of Patent: January 26, 2021Assignee: Talis Biomedical CorporationInventors: Thomas H. Cauley, III, David Alexander Rolfe, Marc Valer Serra
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Publication number: 20210008513Abstract: This disclosure relates to a magnetic mixing apparatus that mixes a sample contained in a mixing chamber using a stir bar, while minimizing the amount of contact between the stir bar and walls of the mixing chamber. In one aspect, the apparatus comprises a ferromagnetic stir bar contained in the mixing chamber, and a driving magnet and a driven magnet located on opposite sides of the mixing chamber. The driving magnet, the driven magnet, and the ferromagnetic stir bar are each capable of rotating about a respective axis. The driving magnet, the driven magnet, and the ferromagnetic stir bar are magnetically coupled such that rotation of the driving magnet induces rotation of the driven magnet and rotation of the driving magnet and the driven magnet induce rotation of the ferromagnetic stir bar. In some embodiments, rotation of the ferromagnetic stir bar within the mixing chamber mixes the sample contained within the mixing chamber.Type: ApplicationFiled: September 12, 2018Publication date: January 14, 2021Applicant: TALIS BIOMEDICAL CORPORATIONInventors: Thomas H. CAULEY, III, David ROLFE
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Patent number: 10820847Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.Type: GrantFiled: October 16, 2019Date of Patent: November 3, 2020Assignee: Talis Biomedical CorporationInventors: Sayeed Andeshmand, Thomas H. Cauley, III, John Dixon, David Glade, Hédia Maamar, Michael John McAdams, Dzam-Si Jesse Ng, David Alexander Rolfe
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Patent number: 10618047Abstract: This disclosure relates to an apparatus for simultaneously filling a plurality of sample chambers. In one aspect, the apparatus comprises a common fluid source and a plurality of independent, continuous fluidic pathways. Each independent, continuous fluidic pathway comprises a sample chamber and a pneumatic compartment. The sample chamber is connected to the common fluid source, and the pneumatic compartment is connected to the sample chamber. The sample chamber comprises, in part, an assay chamber. The assay chamber comprises a monolithic substrate and a plug. In some embodiments, the assay chamber contains a magnetic mixing element. In some embodiments, the assay chamber is a double tapered chamber. In some embodiments, a ratio of a volume of the sample chamber to a volume of the pneumatic compartment is substantially equivalent for each fluidic pathway of the plurality of fluidic pathways.Type: GrantFiled: July 5, 2018Date of Patent: April 14, 2020Assignee: Talis Biomedical CorporationInventor: Thomas H. Cauley, III
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Patent number: D886901Type: GrantFiled: October 23, 2018Date of Patent: June 9, 2020Assignee: Talis Biomedical CorporationInventors: Lance Gordon Hussey, Sobha Pisharody, Marc Valer Serra, Shushuo Wu