Patents Assigned to TALIS BIOMEDICAL CORPORATION
  • Patent number: 11998883
    Abstract: This disclosure relates to a magnetic mixing apparatus that mixes a sample contained in a mixing chamber using a stir bar, while minimizing the amount of contact between the stir bar and walls of the mixing chamber. In one aspect, the apparatus comprises a ferromagnetic stir bar contained in the mixing chamber, and a driving magnet and a driven magnet located on opposite sides of the mixing chamber. The driving magnet, the driven magnet, and the ferromagnetic stir bar are each capable of rotating about a respective axis. The driving magnet, the driven magnet, and the ferromagnetic stir bar are magnetically coupled such that rotation of the driving magnet induces rotation of the driven magnet and rotation of the driving magnet and the driven magnet induce rotation of the ferromagnetic stir bar. In some embodiments, rotation of the ferromagnetic stir bar within the mixing chamber mixes the sample contained within the mixing chamber.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: June 4, 2024
    Assignee: Talis Biomedical Corporation
    Inventors: Thomas H. Cauley, III, David A. Rolfe
  • Patent number: 11986299
    Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: May 21, 2024
    Assignee: Talis Biomedical Corporation
    Inventors: Sayeed Andeshmand, Thomas H. Cauley, III, John Dixon, David Glade, Hédia Maamar, Michael John McAdams, Dzam-Si Jesse Ng, David Alexander Rolfe
  • Patent number: 11920700
    Abstract: Rotary valves and methods of using, manufacturing, and storing the same are provided herein. The rotary valve includes a rotor and a stator, biased toward one another to form a fluid tight seal. In some implementations, the rotor comprises an integrated flow channel containing a porous solid support. Frequently, the interface between rotor and stator is made fluid-tight using a gasket. Some implementations of the rotary valve include a displaceable spacer to prevent the gasket from sealing against at least one of the rotor and stator prior to operation, wherein when the spacer is displaced, the gasket seals the rotor and stator together in a fluid-tight manner.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: March 5, 2024
    Assignee: Talis Biomedical Corporation
    Inventors: Sayeed Andeshmand, Thomas H. Cauley, III, John Dixon
  • Patent number: 11891662
    Abstract: Disclosed herein are primers and probes related to the detection of beta actin [Homo sapiens (human)] via nucleic acid amplification testing (NAAT), for example to amplify and determine the presence of ?-actin present in test samples. Specifically, the present disclosure describes primers and probes that bind to the beta actin gene for detection via loop mediated isothermal amplification (LAMP) and molecular beacon hybridization.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: February 6, 2024
    Assignee: Talis Biomedical Corporation
    Inventors: Jason M. Casolari, Xuewen Jiang, Hédia Maamar
  • Patent number: 11633736
    Abstract: This disclosure relates to an apparatus for simultaneously filling a plurality of sample chambers. In one aspect, the apparatus comprises a common fluid source and a plurality of independent, continuous fluidic pathways. Each independent, continuous fluidic pathway comprises a sample chamber and a pneumatic compartment. The sample chamber is connected to the common fluid source, and the pneumatic compartment is connected to the sample chamber. The sample chamber comprises, in part, an assay chamber. The assay chamber comprises a monolithic substrate and a plug having optically transmissive properties. In some embodiments, the assay chamber contains a magnetic mixing element. In some embodiments, the assay chamber is a double tapered chamber. In some embodiments, a ratio of a volume of the sample chamber to a volume of the pneumatic compartment is substantially equivalent for each fluidic pathway of the plurality of fluidic pathways.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: April 25, 2023
    Assignee: TALIS BIOMEDICAL CORPORATION
    Inventor: Thomas H. Cauley, III
  • Publication number: 20230002826
    Abstract: Disclosed herein are primers and probes related to the detection of beta actin [Homo sapiens (human)] via nucleic acid amplification testing (NAAT), for example to amplify and determine the presence of ?-actin present in test samples. Specifically, the present disclosure describes primers and probes that bind to the beta actin gene for detection via loop mediated isothermal amplification (LAMP) and molecular beacon hybridization.
    Type: Application
    Filed: December 1, 2020
    Publication date: January 5, 2023
    Applicant: TALIS BIOMEDICAL CORPORATION
    Inventors: Jason M. CASOLARI, Xuewen JIANG, Hedia MAAMAR
  • Patent number: 11542545
    Abstract: Disclosed herein are methods and devices for rapid assessment of whether a microorganism present in a sample is susceptible or resistant to a treatment.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: January 3, 2023
    Assignees: California Institute of Technology, Talis Biomedical Corporation
    Inventors: Rustem F. Ismagilov, Eugenia Khorosheva, Travis S. Schlappi, Matthew S. Curtis, Nathan G. Schoepp, Hedia Maamar, Feng Shen, Erik B. Jue
  • Patent number: 11326214
    Abstract: The invention provides methods and compositions for the detection of Chlamydia trachomatis in a test sample. Its presence or absence in the sample is determined by nucleic acid based testing methods using primers and/or probes and or molecular beacons that bind to the 23S ribosomal genes or gene transcripts.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: May 10, 2022
    Assignee: Talis Biomedical Corporation
    Inventors: Andrea Dedent, Matt Lee, Shuyuan Ma, Hedia Maamar
  • Publication number: 20210331173
    Abstract: This disclosure relates to an apparatus for simultaneously filling a plurality of sample chambers. In one aspect, the apparatus comprises a common fluid source and a plurality of independent, continuous fluidic pathways. Each independent, continuous fluidic pathway comprises a sample chamber and a pneumatic compartment. The sample chamber is connected to the common fluid source, and the pneumatic compartment is connected to the sample chamber. The sample chamber comprises, in part, an assay chamber. The assay chamber comprises a monolithic substrate and a plug having optically transmissive properties. In some embodiments, the assay chamber contains a magnetic mixing element. In some embodiments, the assay chamber is a double tapered chamber. In some embodiments, a ratio of a volume of the sample chamber to a volume of the pneumatic compartment is substantially equivalent for each fluidic pathway of the plurality of fluidic pathways.
    Type: Application
    Filed: March 22, 2019
    Publication date: October 28, 2021
    Applicant: TALIS BIOMEDICAL CORPORATION
    Inventor: Thomas H. CAULEY, III
  • Patent number: 11047007
    Abstract: Disclosed herein are primers and probes related to the detection of SARS-CoV-2 via nucleic acid amplification testing (NAAT), for example to amplify and determine the presence of SARS-CoV-2 in test samples and/or to diagnose Covid-19. Specifically, the present disclosure describes primers and probes that bind to the N gene, ORF1ab, or E gene of SARS-CoV-2 coronavirus for detection via loop mediated isothermal amplification (LAMP) and molecular beacon hybridization.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: June 29, 2021
    Assignee: Talis Biomedical Corporation
    Inventors: Nadya Andini, Kathy Chiu, Xuewen Jiang, Hédia Maamar
  • Patent number: 11009150
    Abstract: Rotary valves and methods of using, manufacturing, and storing the same are provided herein. The rotary valve includes a rotor and a stator, biased toward one another to form a fluid tight seal. In some implementations, the rotor comprises an integrated flow channel containing a porous solid support. Frequently, the interface between rotor and stator is made fluid-tight using a gasket. Some implementations of the rotary valve include a displaceable spacer to prevent the gasket from sealing against at least one of the rotor and stator prior to operation, wherein when the spacer is displaced, the gasket seals the rotor and stator together in a fluid-tight manner.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: May 18, 2021
    Assignee: Talis Biomedical Corporation
    Inventors: Thomas H. Cauley, III, John Dixon
  • Patent number: 11008627
    Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: May 18, 2021
    Assignee: Talis Biomedical Corporation
    Inventors: Sayeed Andeshmand, Thomas H. Cauley, III, John Dixon, David Glade, Hédia Maamar, Michael John McAdams, Dzam-Si Jesse Ng, David Alexander Rolfe
  • Publication number: 20210116049
    Abstract: Rotary valves and methods of using, manufacturing, and storing the same are provided herein. The rotary valve includes a rotor and a stator, biased toward one another to form a fluid tight seal. In some implementations, the rotor comprises an integrated flow channel containing a porous solid support. Frequently, the interface between rotor and stator is made fluid-tight using a gasket. Some implementations of the rotary valve include a displaceable spacer to prevent the gasket from sealing against at least one of the rotor and stator prior to operation, wherein when the spacer is displaced, the gasket seals the rotor and stator together in a fluid-tight manner.
    Type: Application
    Filed: February 15, 2019
    Publication date: April 22, 2021
    Applicant: Talis BioMedical Corporation
    Inventors: Sayeed ANDESHMAND, Thomas H. CAULEY, III, John DIXON
  • Patent number: 10954572
    Abstract: Disclosed herein are primers and probes related to the detection of Neisseria gonorrhoeae via nucleic acid amplification testing (NAAT), for example to amplify and determine the presence of N. gonorrhoeae nucleic acids present in test samples. Specifically the present disclosure describes primers and probes that bind to Cytochrome C or ccpA gene of N. gonorrhoeae for detection via loop mediated isothermal amplification (LAMP) and molecular beacon hybridization.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: March 23, 2021
    Assignee: Talis Biomedical Corporation
    Inventors: Andrea C. Dedent, Hedia Maamar, Dana Kelly Vanatta
  • Publication number: 20210023560
    Abstract: This disclosure relates to an apparatus for simultaneously filling a plurality of sample chambers. In one aspect, the apparatus comprises a common fluid source and a plurality of independent, continuous fluidic pathways. Each independent, continuous fluidic pathway comprises a sample chamber and a pneumatic compartment. The sample chamber is connected to the common fluid source, and the pneumatic compartment is connected to the sample chamber. The sample chamber comprises, in part, an assay chamber. The assay chamber comprises a monolithic substrate and a plug having optically transmissive properties. In some embodiments, the assay chamber contains a magnetic mixing element. In some embodiments, the assay chamber is a double tapered chamber. In some embodiments, a ratio of a volume of the sample chamber to a volume of the pneumatic compartment is substantially equivalent for each fluidic pathway of the plurality of fluidic pathways.
    Type: Application
    Filed: March 22, 2019
    Publication date: January 28, 2021
    Applicant: TALIS BIOMEDICAL CORPORATION
    Inventor: Thomas H. CAULEY, III
  • Patent number: 10898895
    Abstract: This disclosure relates to an assembly for loading a sample liquid. The assembly comprises an entry port comprising an inlet and a gas vent, and a reservoir. The reservoir comprises a distal wall, a fin, and a continuous fluidic pathway. The fin comprises first and second surfaces and extends from the inlet towards the distal wall. The continuous fluidic pathway comprises a converging channel that is in fluidic communication with the inlet and is defined by the second surface of the fin, and a diverging channel that is defined by the first surface of the fin and is in fluidic communication with the gas vent. At a distal end of the fin, a width of the converging channel at most equals a width of the diverging channel, and the width of the converging channel at most equals a distance between the distal end of the fin and the distal wall.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: January 26, 2021
    Assignee: Talis Biomedical Corporation
    Inventors: Thomas H. Cauley, III, David Alexander Rolfe, Marc Valer Serra
  • Publication number: 20210008513
    Abstract: This disclosure relates to a magnetic mixing apparatus that mixes a sample contained in a mixing chamber using a stir bar, while minimizing the amount of contact between the stir bar and walls of the mixing chamber. In one aspect, the apparatus comprises a ferromagnetic stir bar contained in the mixing chamber, and a driving magnet and a driven magnet located on opposite sides of the mixing chamber. The driving magnet, the driven magnet, and the ferromagnetic stir bar are each capable of rotating about a respective axis. The driving magnet, the driven magnet, and the ferromagnetic stir bar are magnetically coupled such that rotation of the driving magnet induces rotation of the driven magnet and rotation of the driving magnet and the driven magnet induce rotation of the ferromagnetic stir bar. In some embodiments, rotation of the ferromagnetic stir bar within the mixing chamber mixes the sample contained within the mixing chamber.
    Type: Application
    Filed: September 12, 2018
    Publication date: January 14, 2021
    Applicant: TALIS BIOMEDICAL CORPORATION
    Inventors: Thomas H. CAULEY, III, David ROLFE
  • Patent number: 10820847
    Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: November 3, 2020
    Assignee: Talis Biomedical Corporation
    Inventors: Sayeed Andeshmand, Thomas H. Cauley, III, John Dixon, David Glade, Hédia Maamar, Michael John McAdams, Dzam-Si Jesse Ng, David Alexander Rolfe
  • Patent number: 10618047
    Abstract: This disclosure relates to an apparatus for simultaneously filling a plurality of sample chambers. In one aspect, the apparatus comprises a common fluid source and a plurality of independent, continuous fluidic pathways. Each independent, continuous fluidic pathway comprises a sample chamber and a pneumatic compartment. The sample chamber is connected to the common fluid source, and the pneumatic compartment is connected to the sample chamber. The sample chamber comprises, in part, an assay chamber. The assay chamber comprises a monolithic substrate and a plug. In some embodiments, the assay chamber contains a magnetic mixing element. In some embodiments, the assay chamber is a double tapered chamber. In some embodiments, a ratio of a volume of the sample chamber to a volume of the pneumatic compartment is substantially equivalent for each fluidic pathway of the plurality of fluidic pathways.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: April 14, 2020
    Assignee: Talis Biomedical Corporation
    Inventor: Thomas H. Cauley, III
  • Patent number: D886901
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: June 9, 2020
    Assignee: Talis Biomedical Corporation
    Inventors: Lance Gordon Hussey, Sobha Pisharody, Marc Valer Serra, Shushuo Wu