Abstract: A system for the precise and accurate injection of therapeutic substances in a small specific site in the patient's body that includes a syringe, a miniature video camera, lighting means, control buttons, a power source, and a camera-display connecting means. The miniature video camera is positioned on the syringe and the lens of the camera is positioned on the front end of the syringe and is directed towards the needle/needle array tip area. The lighting means are positioned on the front end of the syringe and are designed to illuminate the needle tip area. The control buttons are designed to control the camera and the lighting means. The camera-display connecting means is designed to connect the camera to a display, which is designed to show the area as photographed by the camera.

Abstract: The present invention encompasses modified luciferases, methods for making modified luciferases, and assays utilizing modified luciferases. Modified luciferases of the invention show increased activity over wildtype luciferases and also show increased stability of signal. The present invention also encompasses multiplex assays utilizing multiple luciferases with different emission spectra.

Abstract: Systems and methods for providing a wider FOV for a telescope system are disclosed. In one embodiment, a telescope includes a primary mirror having an orifice, where an optical path originates from an object positioned in front of the primary mirror and reflects off the primary mirror. A secondary mirror is disposed adjacent to the primary mirror, where the optical path reflects off the secondary mirror and passes through the orifice in the primary mirror. The telescope includes a set of extended field corrector optics disposed along the optical path, the extended field corrector optics positioned to reflect light incident from the secondary mirror, where the set of extended field corrector optics comprises two corrector mirrors. A tertiary mirror is disposed along the optical path and adjacent to the extended field corrector optics, the tertiary mirror positioned to reflect the light incident from the extended field corrector optics.

Abstract: The present invention encompasses modified luciferases, methods for making modified luciferases, and assays utilizing modified luciferases. Modified luciferases of the invention show increased activity over wildtype luciferases and also show increased stability of signal. The present invention also encompasses multiplex assays utilizing multiple luciferases reporters with different emission spectra and different substrates for simultaneous luciferase measurements.

Abstract: The present invention relates to fluorocarbon vectors for the delivery of influenza antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-influenza antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics in animals, including humans.

Abstract: The present invention relates to fluorocarbon vectors for the delivery of antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics in animals.

Abstract: The present invention relates to fluorocarbon vectors for the delivery of influenza antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-influenza antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics in animals, including humans.

Abstract: The present invention encompasses modified luciferases, methods for making modified luciferases, and assays utilizing modified luciferases. Modified luciferases of the invention show increased activity over wildtype luciferases and also show increased stability of signal. The present invention also encompasses multiplex assays utilizing multiple luciferases with different emission spectra.

Abstract: The present invention relates to fluorocarbon vectors for the delivery of antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics in animals.

Abstract: The present invention relates to fluorocarbon vectors for the delivery of antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics in animals.

Abstract: The present invention relates to fluorocarbon vectors for the delivery of antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics in animals.

Abstract: Methods and compositions are described for assaying luciferase bioluminescence in vitro and in vivo cells. The compositions provide at least one of enhanced stability of signal or magnitude of signal by varying the composition of the buffer. One or more of the following parameters have been varied: the presence or absence of EDTA, the concentration of NaCI, the concentration of coelenterazine, the evaluation of ionic and non-ionic detergent, the amount of detergent, how the detergent has been added and the time over which the signal has been recorded. Also disclosed are dual reporter systems.

Abstract: This invention provides a conjugate comprising Substance P, or an analog thereof, and a protein, such as Saporin, that inhibits protein synthesis. This invention provides a method of reducing the perception of pain by a subject comprising administering to the subject an effective amount of the pharmaceutical composition of the conjugate comprising Substance 9, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, so as to reduce the perception of pain by the subject. This invention provides a method of selectively destroying NK-1R-expressing neuronal cells in a subject comprising administering to the subject an effective amount of the conjugate comprising Substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, so as to selectively destroy NK-1R-expresssing neuronal cells.

Abstract: An objective lens assembly suitable for use in helmet-mounted applications. The objective lens assembly comprises two prisms that collectively are configured, oriented and bonded relative to each other to separate and allow simultaneous imaging of two separate spectral bands (such as VNIR and LWIR bands) received from the same object scene via a common window such that the object scene may be viewed from the same perspective without the effects of parallax.

Abstract: This invention provides a conjugate comprising Substance P, or an analog thereof, and a protein, such as Saporin, that inhibits protein synthesis. This invention provides a method of reducing the perception of pain by a subject comprising administering to the subject an effective amount of the pharmaceutical composition of the conjugate comprising Substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, so as to reduce the perception of pain by the subject. This invention provides a method of selectively destroying NK-1R-expressing neuronal cells in a subject comprising administering to the subject an effective amount of the conjugate comprising Substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, so as to selectively destroy NK-1R-expressing neuronal cells.

Abstract: A method for manufacturing an imaging device is provided. The method comprises forming a contact pad over a semiconductor substrate. The contact pad has a malleable metal. The method further comprises providing a readout circuit having a first side and a contact plug. The contact plug has a base affixed to the first side of the readout circuit and a plurality of prongs extending from the base away from the first side. The first side of the readout circuit is moved towards the substrate so that the prongs of the contact plug are pressed into the pad and displace a portion of the pad into a space defined by and between a first and a second of the prongs. Stop elements formed over the substrate are aligned with and contact stop elements provided on the readout circuit so that the prongs are inhibited from passing completely through the contact pad.

Abstract: The present invention relates to fluorocarbon vectors for the delivery of antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics in animals.

Abstract: A bearing assembly suitable for use in a gimbal servo system is provided. The bearing assembly comprises a shaft having an end adapted to be coupled to a payload, a sleeve disposed over the shaft, an inner bearing rotatingly coupled to the shaft and the sleeve, an outer housing disposed over the sleeve, an outer bearing rotatingly coupled to the sleeve and the outer housing such that the sleeve is adapted to rotate about the shaft relative to the housing, a first motor operatively configured to rotate the shaft relative to the outer housing, and a second motor operatively configured to rotate the sleeve about the shaft. The second motor rotates the sleeve in a predetermined direction at a predetermined velocity such that a sum of the predetermined velocity and a velocity associated with inner bearing friction remains positive regardless of the direction of the shaft rotation.

Abstract: A vibration isolator system for attaching a payload to a supporting base is provided, the payload having a center of mass and the system consisting of at least three vibration isolating pods. Each pod has two associated, non-parallel, elastic struts. A first end of each strut is attached to the supporting base and a second end of each strut is attached to the payload at a respective mounting point, and the a projected elastic center of the system is substantially co-located with said center of mass. The vibration isoloator system is operable to substantially prevent translational vibration of the supporting base from inducing angular rotation of the payload.

Abstract: An image sensor is provided that includes a focal plane array; a cold shield having a top wall disposed over the focal plane array and defining an aperture operatively configured to be selectively switched between a first diameter and a second diameter that is larger than the first diameter; and a filter element disposed between the cold shield aperture and the focal plane array. The filter element includes a first band-pass filter and a second band-pass filter. The first band-pass filter is disposed directly beneath the cold shield aperture when the cold shield aperture is switched to the first diameter or the second diameter. The second band-pass filter is covered by the top wall of the cold shield when the cold shield aperture is switched to the first diameter and is disposed directly beneath the cold shield aperture when the cold shield aperture is switched to the second diameter.