Abstract: An aspect of some embodiments of the invention relates to methods of manufacturing a 3D printed implant, comprising printing a mold of a scaffold, generating said scaffold from said mold, seeding cells on said scaffold, where said generating said scaffold comprises generating parts of said scaffold with different levels of stiffness.
Type:
Application
Filed:
January 4, 2022
Publication date:
February 29, 2024
Applicants:
Technion Research & Development Foundation Limited, Tel HaShomer Medical Research Infrastructure and Services Ltd.
Abstract: Provided are methods for diagnosing or selecting a mammal in need of a stimulant ADHD drug, conducting a non-specific electro-dermal responses (EDAs) analysis and/or an auditory sustained attention (ASAT) analysis on the mammal and administering or adjusting the dose of a stimulant ADHD drug to be administered to the mammal.
Type:
Grant
Filed:
August 15, 2019
Date of Patent:
February 27, 2024
Assignee:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Abstract: Provided herein is a porous ?-cyclodextrin-containing monolith having a microstructure templated by the external phase of a HIPE, as well as processes of manufacturing the same and uses thereof.
Type:
Grant
Filed:
August 2, 2021
Date of Patent:
February 27, 2024
Assignee:
Technion Research & Development Foundation Limited
Inventors:
Rajashekharayya A. Sanguramath, Inna Berezovska, Michael S. Silverstein
Abstract: A method for reconstructing spatial information, the method includes: (i) Obtaining an under-sampled frequency domain representation (FDR) of the spatial information. The under-sampled FDR was obtained by sampling an FDR of the spatial information with a sampling mask. (ii) Feeding the under-sampled FDR and the sampling mask to a machine learning process. (iii) Reconstructing the spatial information by the machine learning process. The machine learning process was trained using a training data set that includes training under-sampled FRDs of training spatial information, and one or more training sampling masks that were used to sample FDRs of training spatial information.
Type:
Application
Filed:
August 14, 2023
Publication date:
February 15, 2024
Applicant:
Technion Research & Development Foundation Limited
Abstract: An assembly for driving movement of an elongate surgical tool, comprising: a plurality of adjacent pairs of driving wheels, each pair of driving wheels having a space therebetween such that spaces of the plurality of pairs of driving wheels are axially aligned to form a channel for the elongate surgical tool to extend through; wherein at least one pair of driving wheels out of the plurality of pairs is arranged to lie on a plane different than a plane on which at least one other pair of driving wheels lies.
Type:
Application
Filed:
October 19, 2023
Publication date:
February 8, 2024
Applicants:
Microbot Medical Ltd., Technion Research & Development Foundation Limited
Inventors:
Simon SHARON, Idan BOADER, Evgeny KOFMAN, Zev SOHN, Moshe SHOHAM, Eran COHEN, Eyal MORAG
Abstract: A surface-emitting light source system for generating coherent light having two spin modes comprises a two-dimensional material exhibiting a direct band gap. The two-dimensional material is coupled to a planar heterostructure cavity having an inversion asymmetric core region at least partially surrounded by an inversion symmetric cladding region.
Type:
Application
Filed:
July 27, 2023
Publication date:
February 1, 2024
Applicant:
Technion Research & Development Foundation Limited
Abstract: Compositions comprising a tetraaryl ammonium salt, a tetraaryl ammonium salt covalently bound to a polymer and methods for manufacturing the same are disclosed. The disclosed compositions are useful e.g., for an anion exchange membrane, or an anion conducting polymer, and may further be used in electrochemical devices such as alkaline fuel cells, and alkaline redox-flow batteries.
Type:
Grant
Filed:
August 29, 2019
Date of Patent:
January 30, 2024
Assignee:
Technion Research & Development Foundation Limited
Inventors:
Charles Eliezer Diesendruck, Dario Dekel
Abstract: A system for generating light, comprises a spectral light source, characterized by a spectral line shape described by a visibility function; and a multimode waveguide, characterized by an optical path difference distribution described by a standard deviation. The standard deviation typically matches, within a predetermined tolerance, a location of a zero point of the visibility function at which a contrast of the visibility function is less than 0.1.
Type:
Grant
Filed:
April 16, 2021
Date of Patent:
January 23, 2024
Assignee:
Technion Research & Development Foundation Limited
Inventors:
Carmel Rotschild, Daria Negri, Michal Shimanovich, Matej Kurtulik
Abstract: A method of analyzing the therapeutic efficacy of a therapeutic agent for treating an immune-related disorder is disclosed. The method comprises contacting blood cells of the subject with the agent, measuring the expression of at least 20 genes in the blood cells of the subject; obtaining an immune age value based on the expression of the at least 20 genes, and comparing the immune age value with an immune age value of the subject calculated on the basis of expression of the at least 20 genes in blood cells of the subject, in the absence of the agent.
Type:
Application
Filed:
October 26, 2021
Publication date:
January 18, 2024
Applicants:
Technion Research & Development Foundation Limited, Rambam Med-Tech Ltd.
Inventors:
Shai S. SHEN-ORR, Yehuda CHOWERS, Ayelet ALPERT, Shiran GERASSY-VAINBERG, Erik FELDMAN
Abstract: A system comprising: at least one hardware processor; and a non-transitory computer-readable storage medium having stored thereon program instructions, the program instructions executable by the at least one hardware processor to: receive a data stream representing events; receive a plurality of complex event patterns (CEPs) comprising (a) a set of conditions reflecting relations among said events, and (b) a set of attributes associated with each of said events; and calculate an optimal multi-pattern evaluation plan corresponding to said CEPs by: (i) generating an initial evaluation plan, (ii) applying a search method to calculate modified versions of said initial evaluation plan, (iii) assigning a score to each of said modified versions based on a cost function, and (iv) selecting one of said modified versions having a highest said score as said optimal multi-pattern evaluation plan.
Type:
Grant
Filed:
January 7, 2020
Date of Patent:
January 16, 2024
Assignee:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Abstract: A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5? position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.
Type:
Grant
Filed:
April 8, 2021
Date of Patent:
January 9, 2024
Assignee:
Technion Research & Development Foundation Limited
Inventors:
Timor Baasov, Dana Atia-Glikin, Jeyakumar Kandasamy, Valery Belakhov
Abstract: A method for locating a vessel, the method comprising illuminating at least a portion of the vessel with a background light having a substantially high susceptibility to absorption by particles in said portion of the vessel; detecting backscattered light from said illuminated portion of the vessel; reproducing an image from said backscattered light; and identifying dark regions within said reproduced image.
Type:
Grant
Filed:
May 11, 2020
Date of Patent:
December 26, 2023
Assignee:
Technion Research & Development Foundation Limited
Abstract: An optical digital to analog converter (oDAC) that may include (a) multiple optical paths that are parallel to each other; (b) a combiner, (c) a splitter that is configured to receive an optical signal at a splitter input and split the optical signal between multiple splitter outputs to provide multiple path input signals to the multiple optical paths. The multiple optical paths are configured to optically process, in parallel, path input signals to provide path output signals. Each optical path is configured to apply an optical process that comprises applying optical modulation, by an optical gate of the optical path and under a control of an electrical modulator, to provide an optical signal having a value selected out of multiple constellation levels. The combiner is configured to add the multiple path output signals to provide an oDAC output signal having a value selected from values of a single quadrature constellation.
Type:
Application
Filed:
May 19, 2023
Publication date:
December 21, 2023
Applicant:
Technion Research & Development Foundation Limited
Abstract: The present disclosure is directed to methods and compositions for inhibiting a cancer cell using nucleic acid sequences encoding elephant p53 or elephant p53 amino acid sequences.
Type:
Grant
Filed:
June 5, 2020
Date of Patent:
December 5, 2023
Assignees:
UNIVERSITY OF UTAH RESEARCH FOUNDATION, TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Inventors:
Joshua Schiffman, Avi Schroeder, Lisa Abegglen
Abstract: An airfoil surface skin, comprising a network of a solid material, embedded in a base of deformable solid material. Fluid pressure applied to the interface between the network and the surrounding embedding material, opens an internal network of channels by viscous peeling of the surrounding solid from the network. The network is offset from the centerline the surround material, such that pressure driven viscous flow through the narrow channels generates two types of deformation of the skin—an in-plane elongation and a curvature of the skin plane itself. The shape of the internal solid core element and its material, and the material of the encompassing solid are chosen to achieve a desired integral structural rigidity. The injected fluid pressure determines the extent of extension and bending. Use of this skin enables shape amending airfoils having reduced drag compared with similar airfoils having conventional flap mechanisms.
Type:
Grant
Filed:
January 15, 2020
Date of Patent:
December 5, 2023
Assignee:
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED
Abstract: Provided herein is forward osmosis-based water purification process, that includes contacting a solution of a soluble draw agent with a dehydrated insoluble draw agent, separating the now hydrated insoluble draw agent from the now concentrated draw solution, and exerting a stimulus on the hydrated insoluble draw agent for extracting water therefrom, thereby regenerating a dehydrated insoluble draw agent, wherein the osmotic concentration (osmolality) of the insoluble draw agent is greater than the osmotic concentration of the diluted draw solution, and the insoluble draw agent is impermeable to the soluble draw agent.
Type:
Grant
Filed:
March 3, 2022
Date of Patent:
November 28, 2023
Assignee:
Technion Research & Development Foundation Limited
Abstract: A method for localization of a drone within a building, the method may include (a) detecting, by an acoustic detection unit of the drone, sounds generated by a propulsion unit of the drone while the drone is located within the building; and (b) determining, by a processing unit of the drone, the location of the drone within the building, based on the sounds and on building acoustic information regarding sounds detected at different portions of the building.
Type:
Application
Filed:
May 11, 2023
Publication date:
November 16, 2023
Applicant:
Technion Research & Development Foundation Limited
Abstract: Modified quinolones (e.g., fluoroquinolones) featuring a quinolone (e.g., fluoroquinolone) skeleton having conjugated thereto, via selected linkers, a metal chelating moiety, and metal complexes thereof, are provided. Uses of the compounds and complexes in treating medical conditions associated with pathogenic microorganism are also provided.
Type:
Application
Filed:
July 13, 2023
Publication date:
November 9, 2023
Applicant:
Technion Research & Development Foundation Limited