Abstract: The present invention relates to a ligand-SIFA-chelator conjugate, comprising, within in a single molecule three separate moieties: (a) one or more ligands which are capable of binding to a disease-relevant target molecule, (b) a silicon-fluoride acceptor (SIFA) moiety which comprises a covalent bond between a silicon atom and a fluorine atom, and (c) one or more chelating groups, optionally containing a chelated nonradioactive or radioactive cation.
Type:
Grant
Filed:
July 30, 2018
Date of Patent:
August 16, 2022
Assignees:
Technische Universität München, Technische Universität München—Klinikum Rechts der Isar
Inventors:
Alexander Josef Wurzer, Hans-Jürgen Wester, Matthias Johannes Eiber