Abstract: A semiconductor device for emitting electromagnetic radiation, and to a method of producing the same, which can be used as a semiconductor-based, structured light source. The semiconductor device comprises a layer stack structure composed of an n-doped layer, an active layer and a p-doped layer, as well as a connection structure comprising conductor layers and at least one insulator layer, the conductor layers being arranged, parallel to and spaced apart from one another, along a first direction that is parallel to the active layer of the layer stack structure, and at least one insulator layer being arranged between at least two conductor layers, one or more conductor layers being electrically connected to the p-doped layer of the layer stack structure.

Abstract: An optical detection device having a light detection device and a light emission device is arranged such that the light detection side of the light detection device is optically coupled to a light emission side of a light source array of the light emission device via an examination region. The light detection device generates an electrical signal n response to light that reaches the light detection side. The light source array includes a plurality of separately actuatable electric light sources which are arranged in a matrix structure or two dimensional geometric arrangement. The object to be examined can be arranged in a desired fashion, and the light emitted by the light sources radiates via the examination region on the light detection side of the light detection device. An optical reduction is system is arranged in the beam path from the light emission side to the examination region and is configured to demagnify the light pattern which is emitted by the light sources.

Abstract: The present invention relates to human tissue kallikrein 7 (KLK7) selective inhibitor compounds, combinations including these compounds, process to obtain the referred compounds, and methods of using the same. The present invention belongs to the field of chemistry, pharmacology and medicine.

Abstract: The present disclosure provides methods and composition including vaccines, monoclonal antibodies, polyclonal antibodies, chimeric molecule of an extracellular fibrinogen binding protein (Efb) and targeted agent delivery pharmaceutical composition comprising at least a portion of a modified N-terminus region, at least a portion of a modified C-terminus region, or both, wherein the modified extracellular fibrinogen binding protein results in inhibiting the fibrinogen binding, C3 binding, or both or administering to a subject a pharmacologically effective amount of a vaccine in a pharmaceutically acceptable excipient, comprising a modified extracellular fibrinogen binding protein comprising at least a portion of a modified N-terminus region, at least a portion of a modified C-terminus region, or both, wherein the modified extracellular fibrinogen binding protein results in not shielding the staphylococcus bacterium from recognition by a phagocytic receptor.

Abstract: A semiconductor device for emitting electromagnetic radiation, and to a method of producing the same, which can be used as a semiconductor-based, structured light source. The semiconductor device comprises a layer stack structure composed of an n-doped layer, an active layer and a p-doped layer, as well as a connection structure comprising conductor layers and at least one insulator layer, the conductor layers being arranged, parallel to and spaced apart from one another, along a first direction that is parallel to the active layer of the layer stack structure, and at least one insulator layer being arranged between at least two conductor layers, one or more conductor layers being electrically connected to the p-doped layer of the layer stack structure.

Abstract: The invention provides a fusion protein for use in the treatment of HvG disease in a patient having received a transplant, for use in suppressing the host's immune response directed against the transplant. The fusion protein is adapted for use in suppressing the immune rejection of a transplant which contains or expresses HLA-A*02 or SLA-01*0401 in a recipient patient who is negative for HLA-A*02 or SLA-01*0401, i.e. the patient prior to transplantation does not express HLA-A*02 or SLA-01*0401. The fusion protein is a chimeric antigen receptor (CAR), which upon expression in regulatory T-cells (Treg) causes a specific suppressor activity of the regulatory T-cells in the presence of HLA-A*02 or SLA-01*0401.

Abstract: The present invention relates to combinations of tick-derived antigens for use as a tick vaccine.

Abstract: The invention relates to a method for coordinating access to a resource of a distributed computer system, which has a plurality of distributed client stations, wherein there are at least two client stations, each having at least one computer, at least one resource of the computer system, at least one resource manager, which is designed to manage the resources of the computer system assigned thereto, and at least one internal communication medium, via which the at least one computer, the at least one resource and the at least one resource manager are coupled, client-station-internally, for carrying out data communication, wherein the client stations are coupled to each other via at least one external communication medium in order to carry out data communication. According to the invention, the client stations can communicate among each other. The invention furthermore relates to a computer system of this kind and a computer program for carrying out the method.

Abstract: Multi-phase electronic power converter (50) for outputting multi-phase alternating current, wherein for every phase the current converter (50) comprises a power output (52) controlled via at least two semiconductor switches (51) connected in a half-bridge circuit, wherein the electronic power converter (50) has a control device (53) which is configured for processing a target value signal of the control device (53) supplied as an input signal, each in the form of a bit stream (1, 2, 3, 30, 31, 32) of one or more bits for every phase, characterized in that the control device (53) is configured by means of space-vector modulation to generate actuation signals (P1, P2, P3) of the semiconductor switches (51) in relation to the bit streams (1, 2, 3, 30, 31, 32) supplied as an input signal.

Abstract: Positioning structures in at least one indentation present on a or in a support, wherein said indentation is an indentation having a diameter in the nanometer range, makes it possible to position the structure in the indentation substantially centrally with defined orientation. A support having at least one indentation, wherein the indentation has a size in the nanometer range, includes a predetermined structure which is arranged substantially centrally within said indentation and which optionally has a functional unit diametrically opposite to the side pointing to the bottom surface. The arrangement is especially suitable for single molecule analysis and, here especially, for single molecule sequencing and other high-throughput methods.

Abstract: A measuring method for analyzing the propagation of electromagnetic navigation signals, wherein at least one representative transmitting unit, having a chronological signal feed scheme unambiguously assigned to the navigation signal, is assigned to each of the navigation signals. The representative transmitting units are at least intermittently operated offset in time. A characteristic transmission-free leader pause duration and transmission-free trailer pause duration or a characteristic transmitting duration is assigned to each representative transmitting unit. An analysis unit is coupled to a receiving unit and a time-dependent amplitude detection is carried out, wherein the time curve of the received amplitude values is analyzed by the analysis unit to assign the representative transmitting unit to timeslots of the received amplitude values.

Abstract: The invention relates to a power circuit breaker that is suitable for switching electrical voltages. The power circuit breaker according to the invention comprises two main electrodes, to each of which a respective pole of the voltage to be switched can be connected. During the switching process, at least one of said main electrodes follows a switching path. The power circuit breaker is characterized in that secondary electrodes are additionally provided, which protrude into the vicinity of the switching path and are designed and arranged in such a way that arcs can be produced (a) between the main electrodes and the secondary electrodes and (b) between the individual secondary electrodes during the switching process. The power circuit breaker according to the invention can be advantageously used in vehicles and in ultra-high-voltage AC and HVDC (high-voltage direct current) transmission systems and causes arcs to be extinguished as early as possible during the switching process.

Abstract: The present invention relates to a method and a suitable apparatus for determining the state of a rechargeable battery and for checking contact resistances in a battery system. According to the invention, an impedance curve is determined using signals at different frequencies and a value for an area, which results from the impedance curve, is then calculated from a predetermined threshold value and an x axis. The value for the area is a measure of the ageing of the battery. A control signal is generated on the basis thereof. In one preferred embodiment, said control signal is used to drive a signaling apparatus and thus to present the state of the battery to a user. The present invention can be used, for example, in motor vehicles that are electrically driven.

Abstract: The invention relates to a medical diagnostic device (1) having at least one sensor matrix (2) for capturing electrical voltage signals at a plurality of locations on the body surface of a person or animal, wherein the diagnostic device (1) is set up for capturing a signal (12) representing the position of the sensor matrix (2) relative to the body of the person or animal, and for determining position information (14) about the position of the sensor matrix (2) relative to the body, localized image information (13) is determined from the voltage signals, and the localized image information (13) is associated with the position information (14).

Abstract: A method and an arrangement for modeling antenna emission characteristics are disclosed. A slotted microwave waveguide is implemented by separate mechanical modules having slot groups respectively implemented therein. For this purpose, the modules are arranged along at least one first spatial direction, so that the modules sectionally form a part of the delimitation of the waveguide. The waveguide formed can be fed by exciting a waveguide mode and the mode propagates through the interior of the module in the waveguide formed. Screens are arranged in front of the modules, to partially cover the slot groups. Arbitrary emission characteristics can be simulated, wherein no separate feed network is necessary due to the use of a modular waveguide.

Abstract: A method of manufacturing of a semi-conductor element, comprising the following steps: providing a substrate, the substrate having a surface, the surface being partially coated with a coating and having at least one uncoated area, and growing a truncated pyramid of gallium nitride on the uncoated area, wherein the method comprises the following step: growing at least one gallium nitride column on the truncated pyramid.

Abstract: The subject of the present invention is an anti-ricin antibody and the use thereof for the treatment of an individual suffering from ricin poisoning.

Abstract: The invention relates to a pharmaceutical composition with a content in active ingredient that can be an antimycotic, so that the composition is suitable for the treatment of onychomycoses, in particular severe onychomycoses. The inventive formulation is an ointment-like thermogel at body temperature and an inviscid thermogel at lower temperatures and facilitates the permeation of sufficient active ingredient quantities through human fingernails and toenails, in order to also treat severe onychomycoses.

Abstract: A method is provided for producing microscopically small components. The method can produce components with a size of less than 10 ?m. The method includes: (a) Production of a precipitation hardenable alloy comprising at least two phases, in which alloy of a first phase forms a matrix structure in which a second phase is embedded in the form of discrete particles of a size less than 10 ?m; (b) Dissolution of the matrix and separation of particles from the alloy; and (c) Mechanical deformation by forging respectively a separated particle with at least one striking tool to form the desired element.

Abstract: The invention makes available a keratin coating of a support substrate and a method for the production thereof. This keratin coating is suitable particularly for the in vitro or in vivo culturing of epithelial or endothelial cells and, because of its optical transparency, for microscopy. The keratin coating is prepared by applying or coating keratin in the form of nanoparticles from an aqueous keratin solution or keratin suspension. The solution or suspension does not contain any reducing compounds. The keratin solution is prepared preferably from hair, such as human hair. For the preparation of the coating, keratin is brought into solution or into a suspension of nanoparticles by mixing the keratin with an aqueous composition which contains thiourea, urea, and mercaptoethanol.