Abstract: A polarimeter adapted for measurement of the concentration of glucose in a sample includes a laser beam passing through a first polarizer and an optical modulator and split into a measurement beam passing through a FIRST ANALYZER to a first detector coupled to a first amplifier and a reference beam passing through a SECOND ANALYZER to a second detector coupled to a second amplifier. Identical multiple filtering and summing operations are performed on outputs of the first and second amplifiers to produce a first &PSgr;2/2 signal and a first 2&bgr;&PSgr; signal in response to the measurement beam and a second &PSgr;2/2 signal and a second 2&bgr;&PSgr; signal in response to the reference beam. The measurement beam is stabilized by comparing the second &PSgr;2/2 signal to a first reference signal to produce a first error signal and comparing the second 2&bgr;&PSgr; signal to a second reference signal to produce a second error signal.

Abstract: The concentration of glucose in the anterior chamber of an eye is non-invasively measured by guiding a beam through a polarizer (4), a quarter wave plate (6), a polarization modulator (20), and an analyzer (7). After initializing the polarizer and the analyzer to extinguish the beam, it is guided parallel to the iris (56) of the eye (50) and introduced into the anterior chamber (57), wherein it is refracted, impinges on and is reflected from the iris, and exits the anterior chamber approximately collinear with the portion (55A) of the beam incident on the anterior chamber. The beam then is guided onto a detector (10), and a sufficient signal is applied to the polarization modulator to extinguish the beam. The signal represents the glucose concentration in the patient's blood.

Abstract: The concentration of glucose in the anterior chamber of an eye is non-invasively measured by guiding a beam through a polarizer (4), a quarter wave plate (6), a polarization modulator (20), and an analyzer (7). After initializing the polarizer and the analyzer to extinguish the beam, it is guided parallel to the iris (56) of the eye (50) and introduced into the anterior chamber (57), wherein it is refracted, impinges on and is reflected from the iris, and exits the anterior chamber approximately collinear with the portion (55A) of the beam incident on the anterior chamber. The beam then is guided onto a detector (10), and a sufficient signal is applied to the polarization modulator to extinguish the beam. The signal represents the glucose concentration in the patient's blood.