Abstract: An extract enriched in procyanidol oligomers almost free from monomers is obtained by subjecting a crude vegetable extract, for instance from Vitis vinifera, to ultrafiltration on membranes of cut-off from 3,000 to 600, or to a selective extraction with ethers, or esters or mixtures of ethyl acetate and aromatic hydrocarbons.
Type:
Grant
Filed:
September 23, 1992
Date of Patent:
January 16, 1996
Assignees:
Tecnofarmaci S.p.A., Indena S.p.A.
Inventors:
Enrico Frangi, Marco Bertani, Giuseppe Mustich, Gianfranco Tuccini
Abstract: A process for the concentration and purification of raw aqueous solutions of water-soluble non-ionic organic compounds, preferably those which are useful as contrast enhancing agents in diagnostic procedures, such as for example X-ray, NMR and ultra-sound diagnosis, through the use of tangential filtration on membranes is described. The process also allows the recovery of valuable reactants in excess and of reaction solvents, if any, and it is particularly useful for purifying expensive non-ionic iodinated compounds, which now have been widely used in X-ray imaging. The filtration plant is described.
Type:
Grant
Filed:
August 20, 1993
Date of Patent:
September 5, 1995
Assignees:
Bracco International B.V., Tecnofarmaci S.p.A.