Patents Assigned to Temple University of the Commonwealth Systems of Higher Education
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Patent number: 11994427Abstract: A light detection and measurement device comprises a silicon photomultiplier, at least one thermoelectric cooler thermally coupled to the silicon photomultiplier, a sealed enclosure surrounding the silicon photomultiplier and the at least one thermoelectric cooler, the enclosure including a substantially transparent window thermally coupled to the silicon photomultiplier, and a heat sinking device thermally coupled to the enclosure configured to remove waste heat. A method of cooling a silicon photomultiplier is also described.Type: GrantFiled: September 27, 2019Date of Patent: May 28, 2024Assignee: Temple University-Of The Commonwealth System of Higher EducationInventors: C. J. Martoff, Donald Jones, Andrew Ponento
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Patent number: 11993791Abstract: The invention provides compositions and methods for modifying the 3?-terminal ends of nucleic acids using DNA polymerase ? terminal transferase activity.Type: GrantFiled: December 14, 2020Date of Patent: May 28, 2024Assignee: Temple University-Of The Commonwealth System of Higher EducationInventors: Richard T. Pomerantz, Tatiana Kent
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Patent number: 11989679Abstract: A method for quantifying the professional development of a subject includes storing, on a non-transitory computer-readable medium, a base professional development score for a subject, receiving a submission pertaining to a professional development activity of the subject, approving the submission based on at least one professional development criteria, assigning a value to the approved submission, adjusting the base professional development score according to the approved submission value, comparing the adjusted professional development score to a threshold value, and determining that the subject has achieved a professional development goal when the adjusted professional development score is greater than the threshold value. A system for quantifying the professional development, a system for network-assisted recruitment, and a system for network-assisted learning are also described.Type: GrantFiled: February 27, 2019Date of Patent: May 21, 2024Assignee: Temple University-Of The Commonwealth System of Higher EducationInventors: Munir Y. Mandviwalla, Manoj J. Chacko, Laurel A. Miller
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Patent number: 11963938Abstract: The invention relates to compositions for preventing or delaying the onset of hepatocellular cancer. The compositions of the invention may comprise short chain fatty acids. The compositions of the invention may also comprise probiotic bacteria. The compositions of the invention include compositions for preventing or delaying the onset of hepatocellular cancer by treating or preventing liver inflammation, liver disease, and precancerous lesions.Type: GrantFiled: July 19, 2021Date of Patent: April 23, 2024Assignee: Temple University-Of The Commonwealth System of Higher EducationInventor: Mark A. Feitelson
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Publication number: 20240093866Abstract: Apparatus for increasing burning efficiency including a bottom shell having a plate defining a first opening for receiving a fuel source and a side wall extending in an upward direction. The side wall has a first side wall end coupled to the plate and a second side wall end spaced from the first side wall end in the upward direction. Additionally, the apparatus includes a top shell having inner and outer walls defining a cavity for receiving the second side wall end of the side wall of the bottom shell. The inner wall has a first inner end and a second inner end and the outer wall has a first outer end and a second outer end. The first inner end is coupled to the first outer end and the second inner end is spaced from the second outer end to receive at least the second side wall end.Type: ApplicationFiled: September 15, 2022Publication date: March 21, 2024Applicant: Temple University of the Commonwealth System of Higher EducationInventors: Haykazuni ANDREASYAN, Oleksandr DILOYAN
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Patent number: 11932789Abstract: Provided herein are luminescent compounds, compositions including the same, and use and synthesis thereof.Type: GrantFiled: November 11, 2020Date of Patent: March 19, 2024Assignee: Temple University- of the Commonwealth System of Higher EducationInventors: Graham Dobereiner, William Sabbers, Weerasiri Arachchige Kushan Chandana Weerasiri
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Patent number: 11896037Abstract: The present invention relates to compositions and methods for masking the taste of an agent. In certain aspects, the invention comprises a microsphere and at least one sweetener therein. In another aspect, the invention comprises an edible material comprising at least one microsphere comprising an agent and at least one microsphere comprising a sweetener.Type: GrantFiled: August 3, 2017Date of Patent: February 13, 2024Assignee: Temple University-Of The Commonwealth System of Higher EducationInventors: Gregory S. Smutzer, Kevin Lee, Dhruti Patel
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Patent number: 11897870Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.Type: GrantFiled: April 28, 2020Date of Patent: February 13, 2024Assignee: Temple University-Of The Commonwealth System Higher EducationInventors: Daniel J. Canney, Benjamin E. Blass, Rong Gao, Magid Abou-Gharbia
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Patent number: 11873267Abstract: Pharmaceutical compositions of the invention comprise functionalized N,N-dialkylamino phenyl ethers derivatives having a disease-modifying action in the treatment of diseases associated with lysosomal storage dysfunction that include Gaucher's disease, and any disease or condition involving lysosomal storage dysfunction.Type: GrantFiled: May 24, 2017Date of Patent: January 16, 2024Assignee: Temple University-Of The Commonwealth System of Higher EducationInventors: Magid A. Abou-Gharbia, Wayne E. Childers, Marlene A. Jacobson, Rong Fan, Rogelio L. Martinez
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Publication number: 20230390357Abstract: The invention provides methods of treating ischemia/reperfusion injury in a subject. In one example, a method comprises administering a therapeutically effective amount of a pharmaceutical composition that increases levels of Bcl2-associated athanogene 3 (BAG3) polypeptide in ischemic tissue. The invention also provides methods of treating a subject at risk of ischemia/reperfusion injury. In one example, a method comprises administering a therapeutically effective amount of a pharmaceutical composition that increases levels of Bcl2-associated athanogene 3 (BAG3) polypeptide. In the invention methods, in one example, a pharmaceutical composition comprises a nucleic acid encoding BAG3 polypeptide.Type: ApplicationFiled: November 4, 2022Publication date: December 7, 2023Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Arthur M. FELDMAN, Joseph Y. CHEUNG, Kamel KHALILI
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Patent number: 11821625Abstract: Aspects of the invention are directed to systems and apparatuses for efficiently burning fuels. According to one aspect of the invention, apparatus for efficiently burning hydrocarbons includes a housing having a first opening for receiving a fuel, a second opening for expelling the fuel, and a tubular passageway extending between the first opening and the second opening. The tubular passageway includes a central region and an outer region surrounding the central region. The apparatus also includes a plurality of magnets disposed within the passageway. Each of the magnets has a spherical or an ovoid shape. The plurality of magnets define void spaces for passing the fuel such that a central flow rate of the fuel in the central region of the passageway is equivalent to the an outer flow rate of the fuel in an outer region of the passageway.Type: GrantFiled: June 25, 2018Date of Patent: November 21, 2023Assignee: Temple University of the Commonwealth System of Higher EducationInventors: Oleksandr Diloyan, Haykazuni Andreasyan
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Patent number: 11787794Abstract: The present invention includes novel aminothiazole compounds of formula (I), which are useful in preventing or treating cancer in a subject in need thereof.Type: GrantFiled: November 7, 2019Date of Patent: October 17, 2023Assignee: Temple University-Of The Commonwealth System of Higher EducationInventors: Jean-Pierre J. Issa, Hanghang Zhang, Magid Abou-Gharbia, Wayne E. Childers, George C. Morton
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Patent number: 11759442Abstract: The invention relates to compositions and methods that include short chain fatty acids (SCFAs), related therapeutic compounds, and other compounds, including combinations thereof, for the treatment or prevention of diseases or disorders.Type: GrantFiled: June 17, 2021Date of Patent: September 19, 2023Assignee: Temple University-Of The Commonwealth System of Higher EducationInventors: Ira C. Spector, Mark A. Feitelson, Alla Arzumanyan
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Patent number: 11739323Abstract: The invention includes compositions and methods useful for the diagnosis and treatment of head or brain injury in a subject in need thereof, based upon the expression level of at least one miRNA that is associated with head or brain injury.Type: GrantFiled: June 7, 2018Date of Patent: August 29, 2023Assignee: Temple University-Of The Commonwealth System of Higher EducationInventors: Matthew B. Hudson, Dianne Langford, John Jeka, Ryan Tierney
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Patent number: 11672830Abstract: The invention provides one or more of miR-290 family and Lin28a modified cardiac progenitor cell based therapies for the treatment of myocardial infarction. Exosomes derived from one or more of miR-290 family and Lin28a modified cardiac progenitor cells can also be used in cardiac therapy.Type: GrantFiled: April 17, 2017Date of Patent: June 13, 2023Assignee: Temple University-Of The Commonwealth System of Higher EducationInventors: Mohsin Khan, Raj Kishore
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Patent number: 11618158Abstract: The present invention relates to a new pneumatic-actuated multifunctional doming actuator. The doming actuator can be used as a doming actuator, which can maintain machine/robotic operation on vertical surfaces without falling. The doming actuators exhibit rapid switchable adhesion/deadhesion on target surfaces upon pressurizing/depressurizing the embedded spiral pneumatic channels. The present invention also relates to novel load-carrying and climbing soft robots using the doming actuators. The soft robots are operable on a wide range of horizontal and vertical surfaces including dry, wet, slippery, smooth, and semi-smooth surfaces. In addition, the doming actuators can be used as a driving actuator for swimming soft robotics and as an actuator for soft grippers.Type: GrantFiled: June 18, 2018Date of Patent: April 4, 2023Assignee: Temple University-Of The Commonwealth System of Higher EducationInventors: Yichao Tang, Jie Yin
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Publication number: 20230073246Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.Type: ApplicationFiled: October 5, 2022Publication date: March 9, 2023Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Arthur M. Feldman, Douglas G. Tilley, Weizhong Zhu, Kamel Khalili, Walter J. Koch
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Patent number: 11547776Abstract: The present invention provides porous biomimetic scaffolds and methods for making the same. The scaffolds have graded pore sizes for enhanced cell penetration. The scaffolds are useful for wound regeneration by facilitating cell penetration into the scaffold interior and due to their inherent immunomodulatory effects. The scaffolds have tissue modeling specification by mimicking the inherent stratified structure of certain tissues.Type: GrantFiled: April 26, 2018Date of Patent: January 10, 2023Assignee: Temple University-Of The Commonwealth System of Higher EducationInventors: Azadeh Timnak, Peter I. Lelkes, Yah-el H. Har-el
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Patent number: 11542555Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.Type: GrantFiled: May 21, 2020Date of Patent: January 3, 2023Assignee: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Arthur M. Feldman, Douglas G. Tilley, Weizhong Zhu, Kamel Khalili, Walter J. Koch
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Patent number: 11484712Abstract: The present invention provides in part wearable devices for balance control. The wearable devices are capable of non-invasively monitoring and stimulating the wearer's vestibular system such that it produces postural responses. The wearable devices deliver low levels of electrical current to the vestibular system of a user to maintain balance. In one example, the wearable device is in the form of a pair of glasses.Type: GrantFiled: May 31, 2018Date of Patent: November 1, 2022Assignee: Temple University-Of The Commonwealth System of Higher EducationInventors: Peter Igoche Agada, John Jeka