Patents Assigned to Terumo BCT Biotechnologies, LLC
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Patent number: 11938261Abstract: Embodiments are described for treating a fluid, e.g., a biological fluid. The embodiments may include systems, apparatuses, and methods. Embodiments may provide for a flow cell, with a plurality of manipulation elements, through which a fluid is flowed. The fluid may be treated (e.g., exposed to energy) as it moves through the flow cell. In embodiments, the flow cell may be used to inactivate pathogens in the fluid.Type: GrantFiled: July 26, 2019Date of Patent: March 26, 2024Assignee: Terumo BCT Biotechnologies, LLCInventors: Jon A. Dodd, Daniel R. Clement, Dennis J. Hlavinka, Jeremy T. Parsons, Haralambos P. Apostolopoulos
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Patent number: 11815311Abstract: Provided is a gas fill fixture for use in lyophilization, a related system and method. The gas fill fixture includes a chassis, fill indicator and a lid, such that the chassis and lid together form a cavity for receiving a flexible lyophilization container. The system includes a lyophilization container, a lyophilizer and a gas fill fixture incorporating a chassis, a fill indicator and a lid. The method includes process steps for using the system to lyophilize a fluid.Type: GrantFiled: September 6, 2022Date of Patent: November 14, 2023Assignee: Terumo BCT Biotechnologies, LLCInventors: Nathaniel T. Johnson, Rylan A. Summit, Dennis A. Bridges, Dennis J. Hlavinka, Kestas P. Parakininkas, Kirk L. Weimer, Michael Lawrence Glover, Alexander Du Nguyen, Margaret V. Kwiat
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Patent number: 11771814Abstract: Embodiments are described for treating a fluid, e.g., a biological fluid. The embodiments may include systems, apparatuses, and methods. Embodiments may provide for a flow cell, with a plurality of manipulation elements, through which a fluid is flowed. The fluid may be treated (e.g., exposed to energy) as it moves through the flow cell. In embodiments, the flow cell may be used to inactivate pathogens in the fluid.Type: GrantFiled: July 26, 2019Date of Patent: October 3, 2023Assignee: Terumo BCT Biotechnologies, LLCInventors: Jon A. Dodd, Daniel R. Clement, Dennis J. Hlavinka, Jeremy T. Parsons, Haralambos P. Apostolopoulos
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Patent number: 11747082Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and a peelable region including a peelable seal encompassing a boundary between the non-breathable section and the breathable section. The method includes inputting a fluid into a non-breathable section of the container, freezing the fluid, applying, in a lyophilization chamber, vacuum pressure, opening the peelable seal using a pressure differential, applying heat energy, sublimating the fluid and creating a temporary occlusion in a peelable region of the container.Type: GrantFiled: November 28, 2022Date of Patent: September 5, 2023Assignee: Terumo BCT Biotechnologies, LLCInventors: Kestas P. Parakininkas, Eric T. Hansen, Kirk L. Weimer, Nathaniel T. Johnson, Dennis J. Hlavinka
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Patent number: 11740019Abstract: Provided is a loading tray assembly for housing a lyophilization container and a related system and method. The loading tray assembly includes a chassis including a contact void configured to facilitate direct contact between the attached lyophilization container and a lyophilizer shelf. The method includes securing a multi-part lyophilization container including a peelable seal on a lyophilization loading tray assembly, inputting a liquid into a non-breathable section of the lyophilization container, loading the tray assembly into a lyophilizer, freezing the liquid, applying heat energy and a vacuum, the vacuum causing an opening of the peelable seal and occluding the lyophilization container to isolate the frozen liquid.Type: GrantFiled: December 1, 2022Date of Patent: August 29, 2023Assignee: Terumo BCT Biotechnologies, LLCInventors: Nathaniel T. Johnson, Dennis A. Bridges, Alexander Du Nguyen, Margaret V. Kwiat, Kestas P. Parakininkas, Rylan A. Summit
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Patent number: 11634257Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and an occlusion zone encompassing a boundary between the non-breathable section and the breathable section. The non-breathable section is configured to accommodate any of a liquid, a solid, a gas or combination thereof. The breathable section is configured to accommodate only a gas.Type: GrantFiled: September 2, 2020Date of Patent: April 25, 2023Assignee: Terumo BCT Biotechnologies, LLCInventors: Kirk L. Weimer, Nate T. Johnson, Dennis J. Hlavinka, Kestas P. Parakininkas
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Patent number: 11609042Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and a peelable region including a peelable seal encompassing a boundary between the non-breathable section and the breathable section. The method includes inputting a fluid into a non-breathable section of the container, freezing the fluid, applying, in a lyophilization chamber, vacuum pressure, opening the peelable seal using a pressure differential, applying heat energy, sublimating the fluid and creating a temporary occlusion in a peelable region of the container.Type: GrantFiled: March 11, 2020Date of Patent: March 21, 2023Assignee: Terumo BCT Biotechnologies, LLCInventors: Kestas P. Parakininkas, Eric T. Hansen, Kirk L. Weimer, Nathaniel T. Johnson, Dennis J. Hlavinka
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Patent number: 11609043Abstract: Provided is a gas fill fixture for use in lyophilization, a related system and method. The gas fill fixture includes a chassis, fill indicator and a lid, such that the chassis and lid together form a cavity for receiving a flexible lyophilization container. The system includes a lyophilization container, a lyophilizer and a gas fill fixture incorporating a chassis, a fill indicator and a lid. The method includes process steps for using the system to lyophilize a fluid.Type: GrantFiled: March 11, 2020Date of Patent: March 21, 2023Assignee: Terumo BCT Biotechnologies, LLCInventors: Nathaniel T. Johnson, Rylan A. Summit, Dennis A. Bridges, Dennis J. Hlavinka, Kestas P. Parakininkas, Kirk L. Weimer, Michael Lawrence Glover, Alexander Du Nguyen, Margaret V. Kwiat
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Patent number: 11604026Abstract: Provided is a loading tray assembly for housing a lyophilization container and a related system and method. The loading tray assembly includes a chassis including a contact void configured to facilitate direct contact between the attached lyophilization container and a lyophilizer shelf. The method includes securing a multi-part lyophilization container including a peelable seal on a lyophilization loading tray assembly, inputting a liquid into a non-breathable section of the lyophilization container, loading the tray assembly into a lyophilizer, freezing the liquid, applying heat energy and a vacuum, the vacuum causing an opening of the peelable seal and occluding the lyophilization container to isolate the frozen liquid.Type: GrantFiled: March 11, 2020Date of Patent: March 14, 2023Assignee: Terumo BCT Biotechnologies, LLCInventors: Nathaniel T. Johnson, Dennis A. Bridges, Alexander Du Nguyen, Margaret V. Kwiat, Kestas P. Parakininkas, Rylan A. Summit
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Publication number: 20230008773Abstract: Provided is a gas fill fixture for use in lyophilization, a related system and method. The gas fill fixture includes a chassis, fill indicator and a lid, such that the chassis and lid together form a cavity for receiving a flexible lyophilization container. The system includes a lyophilization container, a lyophilizer and a gas fill fixture incorporating a chassis, a fill indicator and a lid. The method includes process steps for using the system to lyophilize a fluid.Type: ApplicationFiled: September 6, 2022Publication date: January 12, 2023Applicant: Terumo BCT Biotechnologies, LLCInventors: Nathaniel T. JOHNSON, Rylan A. SUMMIT, Dennis A. BRIDGES, Dennis J. HLAVINKA, Kestas P. PARAKININKAS, Kirk L. WEIMER, Michael Lawrence GLOVER, Alexander Du NGUYEN, Margaret V. KWIAT
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Patent number: 11460248Abstract: Provided is a gas fill fixture for use in lyophilization, a related system and method. The gas fill fixture includes a chassis, fill indicator and a lid, such that the chassis and lid together form a cavity for receiving a flexible lyophilization container. The system includes a lyophilization container, a lyophilizer and a gas fill fixture incorporating a chassis, a fill indicator and a lid. The method includes process steps for using the system to lyophilize a fluid.Type: GrantFiled: March 11, 2020Date of Patent: October 4, 2022Assignee: Terumo BCT Biotechnologies, LLCInventors: Nathaniel T. Johnson, Rylan A. Summit, Dennis A. Bridges, Dennis J. Hlavinka, Kestas P. Parakininkas, Kirk L. Weimer, Michael Lawrence Glover, Alexander Du Nguyen, Margaret V. Kwiat
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Publication number: 20210016943Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and an occlusion zone encompassing a boundary between the non-breathable section and the breathable section. The non-breathable section is configured to accommodate any of a liquid, a solid, a gas or combination thereof. The breathable section is configured to accommodate only a gas.Type: ApplicationFiled: September 2, 2020Publication date: January 21, 2021Applicant: Terumo BCT Biotechnologies, LLCInventors: Kirk L. WEIMER, Nate T. JOHNSON, Dennis J. HLAVINKA, Kestas P. PARAKININKAS
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Patent number: 10793327Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and an occlusion zone encompassing a boundary between the non-breathable section and the breathable section. The non-breathable section is configured to accommodate any of a liquid, a solid, a gas or combination thereof. The breathable section is configured to accommodate only a gas.Type: GrantFiled: October 9, 2018Date of Patent: October 6, 2020Assignee: Terumo BCT Biotechnologies, LLCInventors: Kirk L. Weimer, Nate T. Johnson, Dennis J. Hlavinka, Kestas P. Parakininkas
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Publication number: 20200292231Abstract: Provided is a gas fill fixture for use in lyophilization, a related system and method. The gas fill fixture includes a chassis, fill indicator and a lid, such that the chassis and lid together form a cavity for receiving a flexible lyophilization container. The system includes a lyophilization container, a lyophilizer and a gas fill fixture incorporating a chassis, a fill indicator and a lid. The method includes process steps for using the system to lyophilize a fluid.Type: ApplicationFiled: March 11, 2020Publication date: September 17, 2020Applicant: Terumo BCT Biotechnologies, LLCInventors: Nathaniel T. JOHNSON, Rylan A. SUMMIT, Dennis A. BRIDGES, Dennis J. HLAVINKA, Kestas P. PARAKININKAS, Kirk L. WEIMER, Michael Lawrence GLOVER, Alexander Du NGUYEN, Margaret V. KWIAT
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Publication number: 20200289728Abstract: Provided is a loading tray assembly for housing a lyophilization container and a related system and method. The loading tray assembly includes a chassis including a contact void configured to facilitate direct contact between the attached lyophilization container and a lyophilizer shelf. The method includes securing a multi-part lyophilization container including a peelable seal on a lyophilization loading tray assembly, inputting a liquid into a non-breathable section of the lyophilization container, loading the tray assembly into a lyophilizer, freezing the liquid, applying heat energy and a vacuum, the vacuum causing an opening of the peelable seal and occluding the lyophilization container to isolate the frozen liquid.Type: ApplicationFiled: March 11, 2020Publication date: September 17, 2020Applicant: Terumo BCT Biotechnologies, LLCInventors: Nathaniel T. JOHNSON, Dennis A. BRIDGES, Alexander Du NGUYEN, Margaret V. KWIAT, Kestas P. PARAKININKAS, Rylan A. SUMMIT
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Publication number: 20200288703Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and a peelable region including a peelable seal encompassing a boundary between the non-breathable section and the breathable section. The method includes inputting a fluid into a non-breathable section of the container, freezing the fluid, applying, in a lyophilization chamber, vacuum pressure, opening the peelable seal using a pressure differential, applying heat energy, sublimating the fluid and creating a temporary occlusion in a peelable region of the container.Type: ApplicationFiled: March 11, 2020Publication date: September 17, 2020Applicant: Terumo BCT Biotechnologies, LLCInventors: Kestas P. PARAKININKAS, Eric T. HANSEN, Kirk L. WEIMER, Nathaniel T. JOHNSON, Dennis J. HLAVINKA
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Publication number: 20200030790Abstract: Embodiments are described for treating a fluid, e.g., a biological fluid. The embodiments may include systems, apparatuses, and methods. Embodiments may provide for a flow cell, with a plurality of manipulation elements, through which a fluid is flowed. The fluid may be treated (e.g., exposed to energy) as it moves through the flow cell. In embodiments, the flow cell may be used to inactivate pathogens in the fluid.Type: ApplicationFiled: July 26, 2019Publication date: January 30, 2020Applicant: Terumo BCT Biotechnologies, LLCInventors: Jon A. DODD, Daniel R. CLEMENT, Dennis J. HLAVINKA, Jeremy T. PARSONS, Haralambos P. APOSTOLOPOULOS
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Publication number: 20200030520Abstract: Embodiments are described for treating a fluid, e.g., a biological fluid. The embodiments may include systems, apparatuses, and methods. Embodiments may provide for a flow cell, with a plurality of manipulation elements, through which a fluid is flowed. The fluid may be treated (e.g., exposed to energy) as it moves through the flow cell. In embodiments, the flow cell may be used to inactivate pathogens in the fluid.Type: ApplicationFiled: July 26, 2019Publication date: January 30, 2020Applicant: Terumo BCT Biotechnologies, LLCInventors: Jon A. DODD, Daniel R. CLEMENT, Dennis J. HLAVINKA, Jeremy T. PARSONS, Haralambos P. APOSTOLOPOULOS
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Publication number: 20190106254Abstract: Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and an occlusion zone encompassing a boundary between the non-breathable section and the breathable section. The non-breathable section is configured to accommodate any of a liquid, a solid, a gas or combination thereof. The breathable section is configured to accommodate only a gas.Type: ApplicationFiled: October 9, 2018Publication date: April 11, 2019Applicant: Terumo BCT Biotechnologies, LLCInventors: Kirk L. WEIMER, Nate T. JOHNSON, Dennis J. HLAVINKA
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Publication number: 20170021042Abstract: Embodiments are described for reducing pathogens in a fluid. The embodiments may include systems, apparatuses, and methods. Embodiments may provide for a flow cell with a plurality of channels through which a fluid to be pathogen reduced is flowed. The flow cell, and fluid, may be illuminated from more than one direction to pathogen reduce the fluid. In embodiments, the fluid may include a photosensitizer to aid in the pathogen reduction process.Type: ApplicationFiled: July 22, 2016Publication date: January 26, 2017Applicant: Terumo BCT Biotechnologies, LLCInventors: Jon A. DODD, Daniel Russell CLEMENT