Abstract: A method of treating a pruritic skin area in a mammal by application to the affected area of a gel composition containing from about 60 to about 90% ethyl alcohol, from about 0.5 to about 30% water, at least one gelling agent and a pharmaceutically effective amount of a topically active, antipruritic, antihistaminic agent. The gel may be applied to the affected area from one to five times daily.

Abstract: Aqueous gel compositions incorporate topically active pharmaceutical agents in a non-irritating gel comprising from about 60 to about 90% ethyl alcohol and from about 0.5 to about 30% water together with at least one gelling agent. Optional additives include gel enhancers, gel neutralizers, ultraviolet absorbers, gel clarifying agents, anti-irritants and moisturizers. The gel compositions exhibit good bactericidal and bacteriostatic activity in addition to the pharmaceutical activity of the active topical ingredient. Methods of treating skin areas in mammals requiring topical medication comprise the application of the gel, with or without the incorporation of a topically active ingredient, to the affected skin areas 1 to 5 times daily.

Abstract: Methods of providing local anti-infective treatment to a human or animal tissue area requriing such treatment comprise the application to the affected tissue area of an effective amount of a composition containing from 0.5 to 5% by weight of selected antihistaminic agents in pharmaceutically acceptable topical vehicles including liquids, lotions, aerosols, creams, gels and ointments.

Abstract: Methods of providing local anti-infective treatment to a human or animal tissue area requiring such treatment comprise the application to the affected tissue area of an effective amount of a composition containing from 0.5 to 5% by weight of selected antihistaminic agents in pharmaceutically acceptable topical vehicles including liquids, lotions, aerosols, creams, gels and ointments.

Abstract: Methods of providing local anti-infective treatment to a human or animal tissue area requiring such treatment comprise the application to the affected tissue area of an effective amount of a composition containing from 0.5 to 5% by weight of selected antihistaminic agents in pharmaceutically acceptable topical vehicles including liquids, lotions, aerosols, creams, gels and ointments.

Abstract: Methods of providing local anti-infective treatment to a human or animal tissue area requiring such treatment comprise the application to the affected tissue area of an effective amount of a composition containing from 0.5 to 5% by weight of selected antihistaminic agents in pharmaceutically acceptable topical vehicles including liquids, lotions, aerosols, creams, gels and ointments.

Abstract: Gel bases for pharmaceutical compositions comprise from about 0.5 to about 10.0% by weight ethoxylated (2 to 30 moles of ethoxylation) behenyl alcohol and from about 90 to 99.5% of a glycol solvent or from about 2.5 to about 10.0% by weight ethoxylated fatty alcohols having a chain length of from 16 to 21 carbon atoms and from 90 to about 97.5% of a glycol solvent. Preferred glycol solvents include propylene glycol and polyethylent glycols having an average molecular weight of about 200 to 800. Pharmaceutical compositions suitable for topical, transmucosal and oral administration may be prepared utilizing the novel gel bases. Methods of administration of topically, systemically and orally active pharmaceutical agents utilizing the novel gel bases are also provided.

Abstract: Anhydrous vehicles for topical use, e.g. for use with topically active pharmaceutical agents, including antibiotics, anti-fungal agents, anti-inflammatory agents, antihistamines, antipruritics and local anesthetics, comprise principally from about 60 to about 90% by weight of at least one glycol solvent and from about 2 to about 20% by weight etherified saturated fatty alcohol having a total chain length of from 20 to 216 carbon atoms. The vehicles are substantially free of water, greasy substances and fatty alcohols having less than 16 carbon atoms. The vehicles have a cream-like consistency and can also incorporate suitable compatible plasticizers, coupling agents, penetrants and the like.