Abstract: A computerized educational method and system that provides educational content using a simulation situation. In one embodiment, one or more medical conditions and a question may be presented about a hypothetical patient using a video display system. The learner may select from a plurality of potential responses to the question. Typically, the plurality of potential responses are categorized into a correct category, a reasonable category, and a wrong category. Upon receiving a selection from the plurality of potential responses, the learner is provided with the category to which the selected response corresponds.

Abstract: Interestingly, for prognosis, the significant biomarkers for Gefitinib-treated GBM patients (RTOG 0211) appeared to differ compared to historical, RT and non-Gefitinib-treated GBM patients. In Gefitinib-treated patients, those with higher levels of nuclear pAKT driven by PTEN loss, higher levels of nuclear pMAPK, and lower levels of nuclear pmTOR had significantly worse clinical outcomes. In contrast, in non-Gefitinib-treated patients, patients with PTEN-deficiency, and higher levels of EGFRvIII, total EGFR, IGFR1, NFkB and lower levels of nuclear Survivin appeared to have adverse clinical outcomes, highlighting the treatment-dependency of these biomarkers.