Abstract: Embodiments of the invention are directed to methods, devices, and compositions for 3D printing of piezoelectric devices. The piezoelectric devices can be used for sensor applications using poly(vinylidene) fluoride (PVDF) and BaTiO3 (BTO) nanocomposites through in-situ electric poling 3D printing process.

Abstract: The present disclosure provides for the identification of biomarkers that are diagnostic for Autism Spectrum Disorder (ASD). The biomarkers include thyroid stimulating hormone (TSH), interleukin 8 (IL-8) and a peptiod recognized by antibodies.

Abstract: The present disclosure describes the C-type lectin CLEC11a as a bone growth factor. Clec11a-deficient mice showed reduced bone volume and mineralization, while bone resorption remained unchanged. Administration of recombinant Clec11a systemically promoted bone formation in mice at risk for osteoporosis.

Abstract: Certain embodiments are directed to method for making and using an alkali promoted transition metal sulfide Fischer Tropsch catalyst. Certain embodiments are directed to alkali promoted transition metal sulfide Fischer Tropsch catalyst synthesized using steps comprising (i) mixing an ammonium tetrathiomolybdate (ATM) precursor compound with an alkali metal compound and molybdenum disulfide in deionized water to form a reaction mixture, (ii) heating the reaction mixture at a temperature of at least 200, 250, 300, 350, 400C at a pressure of at lease 900, 1000, 1100, 1500, 2000 psi for more than 0.5 1, 1.5, 2.0, 3 or more hours to form a reaction product, (iii) filtering, washing, and drying the reaction product.

Abstract: Methods and compositions for detecting and/or measuring biomarkers associated with compromised BBB.

Abstract: Embodiments of the current invention include methods and compositions for regulating the activity of hormone receptors.

Abstract: Certain embodiments are directed to a specimen retrieval device having a high friction inner lining for reducing specimen deformation during removal. Certain embodiments are directed to a device that facilitates isolation and removal of specimens during minimally invasive surgery. In certain aspects the device is configured to disperse pulling tension over a larger area reducing the likelihood of specimen tearing during removal. The device enables quicker removal through a smaller hole or opening in the body wall.

Abstract: Certain embodiments are directed to methods of identifying neuroblastoma differentiation-inducing compounds or agent and their use in treating neuroblastoma.

Abstract: One aspect of the invention provides a method of determining metal ion levels in the patents due to corrosion and wear processes of the metallic implant in a human or veterinary patient. One embodiment provides a cost effective and patient driven early diagnostic method which has a potential application in orthopedics and dentistry. In one embodiment, the method includes the use of an electrochemical biosensor to detect metal ions or particles in a sample taken from a patient having a metallic implant.

Abstract: The present invention provides polysubstituted pyrrole compounds, pharmaceutically effective salts, prodrugs, solvates and hydrates thereof, having antimitotic, antiproliferative and cytotoxic activity, activity against cells expressing the drug efflux protein, P-glycoprotein, or cells expressing the ?-III isotype of tubulin and antitumor activity. Also provided are methods of utilizing these compounds for inhibiting the proliferation of cancer cells as well as their medical use, in particular for treating cancer, including drug resistant cancer.

Abstract: A device for fine needle aspiration comprising: an inner tubular member; an outer tubular member disposed around the inner tubular member, wherein the outer tubular member comprises a plurality of slots; an outer housing disposed around the outer tubular member; a biasing member disposed between the outer tubular member and the outer housing. The device also comprises a rod coupled to the inner tubular member, where the rod extends through the outer tubular member and the rod is configured to be moved from a first slot in the plurality of slots to a second slot in the plurality of slots.

Abstract: The present disclosure concerns uses for isoxazole compounds or salts or analogs thereof for the treatment of wounds. The present disclosure also concerns devices for delivering a isoxazole compound or salts or an analogs thereof to a wound site.

Abstract: Tissue engineered constructs and methods for fabricating the disclosed constructs are provided. Some of the disclosed tissue engineered constructs are designed to fill a void in the body due to surgical resection, for example from mastectomy or lumpectomy, wounds and the like. Some disclosed constructs comprise one or more projections designed to mimic the appearance of a structural feature when implanted into a host.

Abstract: The present invention relates generally to novel allosteric regulators of proteasome activity, methods for preparation and use, and pharmaceutical compositions thereof. Specifically piperidine-2-carboxylic acid derivatives containing 1-oxo-aroyl group and a lipophilic ester side chain are disclosed as allosteric inhibitors of proteasome 2S activity, and as therapeutic agents for the treatment of proteasome-associated disorders in a subject.

Abstract: The present disclosure describes the fusogenic activity of the Myomaker protein. This polypeptide, when expressed in non-muscle cells, is able to drive fusion of the cell with a muscle cell, but not with other non-muscle cells. The use of this protein and cell expressing it in the delivery of exogenous genetic material to muscle cells also is described.

Abstract: Certain embodiments are directed to polypeptide sensors. Certain aspects of the invention are directed to polypeptides for sensing or detecting GTP and GTP concentrations. In further aspects, the polypeptide sensor can measure GTP concentrations, with high temporal and spatial resolution.

Abstract: A method of evaluating a cancer patient comprising evaluating gene expression levels in a patient sample, calculating a predictor score using the gene expression levels, and assessing the likelihood of a therapeutic outcome using the predictor score is disclosed.

Abstract: Disclosed are methods for diagnosing cancer or dysplasia in a sample of tissue, involving testing cells of the sample to assess whether miR-196a expression in cells of the sample is greater than a reference, wherein a greater expression of miR-196a in cells of the sample compared to the reference is indicative of cancer or dysplasia. The cancer or dysplasia may be esophageal cancer or esophageal dysplasia. Also disclosed are method for diagnosing cancer or dysplasia in a sample of tissue, comprising testing cells of the sample to assess whether the expression of ANXA1, KRT5, SPRR2C, or S100A9 in cells of the sample is reduced compared to a reference control, wherein said reduced expression in cells of the sample compared to the reference control is indicative of cancer or dysplasia. Also disclosed are kits and methods involving kits for the diagnosis of cancer or dysplasia.

Abstract: A Raman analyzer for analyzing light emitted from a Raman cell is provided that has a beam splitter configured to split the light emitted from the Raman cell into a first beam and a second beam. An atomic vapor filter can be used to filter a Raman scattered line from the first beam and a chopper system can periodically interrupt the first and second beams that are directed towards a photo detector, which can convert light from the first and second beams into an electrical signal. The signal output from the photo detector can optionally be amplified, digitized, Fourier filtered, and/or subjected to Fourier analysis.

Abstract: The present invention discloses methods to prevent and treat cardiovascular disorders, hi certain aspects the methods are drawn to releasing endogenous calcitonin-gene related peptide from intrinsic cardiac adrenergic cells within the heart. In further aspects, a combination of a ?2 adrenergic receptor agonist ?2-AR agonist) and a vasodilator can be used in treating reperfusion injury.