Abstract: Compounds that specifically kill fluoroquinolone (FQ) resistant bacteria have been developed and are described herein. The FQs are the most commonly prescribed antibiotics to adults in the U.S. and thus are extremely important drugs. However, bacterial resistant to these drugs is now ubiquitous in some of the most common and deadly Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Indeed, FQs are no longer indicated for treatment of MRSA and VRE infections because of such resistance. The compounds have specific and potent activity versus MRSA and VRE.
Type:
Application
Filed:
March 17, 2015
Publication date:
April 6, 2017
Applicant:
The Board of Trustees of the University of IIIinois
Inventors:
Paul J. HERGENROTHER, Elizabeth I. PARKINSON, Joseph S. BAIR
Abstract: The invention provides methods and devices for fabricating printable semiconductor elements and assembling printable semiconductor elements onto substrate surfaces. Methods, devices and device components of the present invention are capable of generating a wide range of flexible electronic and optoelectronic devices and arrays of devices on substrates comprising polymeric materials. The present invention also provides stretchable semiconductor structures and stretchable electronic devices capable of good performance in stretched configurations.
Type:
Application
Filed:
January 14, 2014
Publication date:
July 10, 2014
Applicant:
The Board of Trustees of the University of IIIinois
Inventors:
Ralph G. NUZZO, John A. ROGERS, Etienne MENARD, Keon Jae LEE, Dahl-Young KHANG, Yugang SUN, Matthew MEITL, Zhengtao ZHU
Abstract: A method for producing light emission from a two terminal semiconductor device with improved efficiency, includes the following steps: providing a layered semiconductor structure including a semiconductor drain region comprising at least one drain layer, a semiconductor base region disposed on the drain region and including at least one base layer, and a semiconductor emitter region disposed on a portion of the base region and comprising an emitter mesa that includes at least one emitter layer; providing, in the base region, at least one region exhibiting quantum size effects; providing a base/drain electrode having a first portion on an exposed surface of the base region and a further portion coupled with the drain region, and providing an emitter electrode on the surface of the emitter region; applying signals with respect to the base/drain and emitter electrodes to obtain light emission from the base region; and configuring the base/drain and emitter electrodes for substantial uniformity of voltage distrib
Type:
Application
Filed:
July 22, 2013
Publication date:
February 6, 2014
Applicants:
The Board of Trustees of The University Of IIIinois, Quantum Electro Opto Systems Sdn. Bhd.
Inventors:
Gabriel Walter, Nick Holonyak, JR., Milton Feng, Chao-Hsin Wu
Abstract: Provided herein are fluorescent lipid binding proteins (FLBPs). The FLBPs comprise a lipid binding domain linked to a fluorophore, whrereby the fluorophore's fluorescence emission undergoes a spectral change upon lipid binding. Said fluorophore is selected from the group consisting of 2-dimethylamino-6-acyl-naphthalene (DAN) and RED fluorophore and said lipid binding protein is selected from the group consisting of ENTH domain of epsin 1, C2 domain of bovine lactadherin, C1B domain of protein kinase C-gamma, C2 domain of cytosolic phospholipase A2-beta, and PH domain of Bruton's tyrosine kinase PH.
Type:
Application
Filed:
November 5, 2010
Publication date:
September 6, 2012
Applicant:
The Board of Trustees of the University of IIIinois
Abstract: The invention provides a transcorneal vision assistance device implantable in the eye of a patient. A preferred embodiment transcorneal microtelescope vision assistance device is implantable in the eye of a patient and includes a keratoprosthesis configured to replace a portion of the cornea of a patient and to secure the keratoprosthesis to a remaining front portion of the cornea. A microtelescope is carried by the keratoprosthesis for transcorneal mounting of the microtelescope.
Type:
Application
Filed:
March 13, 2008
Publication date:
July 1, 2010
Applicant:
The Board of Trustees of the University of IIIinois
Inventors:
Dimitri Azar, Jose De La Cruz, Sandeep Jain