Abstract: The present invention relates to footwear and in particular, but not necessarily restricted thereto, relates to footwear for those with diabetes and, in particular, with ulcers of the sole. The present invention seeks to address some of the problems encountered by prior art limb compression devices and methods. In particular the present invention seeks to provide a boot which can stimulate blood flow. A further object to the invention is to provide a boot with a sole which is adaptable to conform with various shapes and conditions of human feet. The present invention also seeks to provide a new type of footwear that has a therapeutic benefit for diabetic patients with circulatory problems in their foot, and also enables the technique of “off loading” the foot to assist in the healing of any wounds present.

Abstract: The present invention relates to footwear and in particular, but not necessarily restricted thereto, relates to footwear for those with diabetes and, in particular, with ulcers of the sole. The present invention seeks to address some of the problems encountered by prior art limb compression devices and methods. In particular the present invention seeks to provide a boot which can stimulate blood flow. A further object to the invention is to provide a boot with a sole which is adaptable to conform with various shapes and conditions of human feet. The present invention also seeks to provide a new type of footwear that has a therapeutic benefit for diabetic patients with circulatory problems in their foot, and also enables the technique of “off loading” the foot to assist in the healing of any wounds present.

Abstract: The present invention relates to footwear and in particular, but not necessarily restricted thereto, relates to footwear for those with diabetes and, in particular, with ulcers of the sole. The present invention seeks to address some of the problems encountered by prior art limb compression devices and methods. In particular the present invention seeks to provide a boot which can stimulate blood flow. A further object to the invention is to provide a boot with a sole which is adaptable to conform with various shapes and conditions of human feet. The present invention also seeks to provide a new type of footwear that has a therapeutic benefit for diabetic patients with circulatory problems in their foot, and also enables the technique of “off loading” the foot to assist in the healing of any wounds present.

Abstract: Compounds of formula I ##STR1## in which R.sub.1 is H or C.sub.1-3 alkyl; R.sub.2 is H or C.sub.1-3 alkyl; R.sub.3 and/or R.sub.4 are H, C.sub.1-3 alkyl, C.sub.3-6 alkenyl, C.sub.3-6 alkynyl, C.sub.3-7 cycloalkyl or R.sub.3 and R.sub.4 together with the nitrogen atom form a heterocyclic ring system; R.sub.5 and/or R.sub.6 are H, halo, CF.sub.3, or C.sub.1-3 alkyl (with the proviso that R.sub.5 and R.sub.6 cannot both be H or methyl) or R.sub.5 and R.sub.6 together with the carbon atoms to which they are attached form a second benzene ring and R.sub.7 and/or R.sub.8 are H or C.sub.1-3 alkyl show therapeutic activity in the treatment of depression. Pharmaceutical compositions and processes for preparing compounds of formula I are disclosed.

Abstract: Novel quinolones of the general formula ##STR1## wherein n is 0, 1 or 2; R.sub.1 is C.sub.1-4 alkyl; and R.sub.3 is hydrogen, C.sub.1-4 alkyl, methoxy, methylthio, halo or trifluoromethyl. These compounds have antihypertensive activity and may be used for treating hypertension in mammals.The quinolones are administered in novel therapeutic compositions comprising a quinolone of the above general formula together with a pharmaceutically acceptable carrier.Processes for making the novel quinolones are described.

Abstract: 2,4-Dichlorobenzyl alcohol is obtained in high purity and in high yield by reacting 2,4-dichlorobenzyl chloride in a two stage reaction with a water soluble salt of an organic acid in the presence of a phase transfer catalyst to give the 2,4-dichlorobenzyl ester of the organic acid which is subsequently hydrolysed with a strong base.

Abstract: Novel compounds are described which are substituted benzophenone hydrazones. They have pesticidal activity, especially against insects and acarids, and pesticidal compositions and methods are described. Methods of making the compounds, and novel intermediates, are also described.

Abstract: A process is disclosed for preparing arylpropionic acids of formula Ar--CH(CH.sub.3)--COOH, by reacting an aryl Grignard reagent with a metal pyruvate or with a pyruvamide, to form a hydroxy acid of formula Ar--C(OH)(CH.sub.3)--COOH or its amide, and converting the acid or amide to the product.

Abstract: Compositions which contain a quinolone compound of the general formula ##STR1## wherein n is 0, 1 or 2; R.sub.1 is lower alkyl optionally substituted by hydroxy or C.sub.1-4 alkoxycarbonyl; allyl; propynyl or phenyl- lower alkyl in which the phenyl ring is optionally substituted by 1 or 2 C.sub.1-4 alkoxy groups; R.sub.2 is C.sub.1-4 alkyl with the proviso that when n is 0, R.sub.2 is methyl; and R.sub.3, R.sub.4 and R.sub.5, which may be the same or different, are hydrogen, lower alkyl, lower alkoxy, lower alkanoyl, halo, trifluoromethyl or lower alkylthio show antihypertensive activity.Compounds of general formula ##STR2## in which n, R.sub.1 R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as described above are novel subject to the following provisos (a) when R.sub.3, R.sub.4 and R.sub.4 and R.sub.5 are hydrogen R.sub.2 is methyl and R.sub.1 is lower alkyl, R.sub.1 contains more than one carbon atom, and(b) when R.sub.3 and R.sub.4 are hydrogen, R.sub.5 is hydrogen or 7-methyl, and R.sub.1 is ethyl, R.sub.

Abstract: A new method of controlling pests harmful to domestic animals and certain novel pesticidal compositions are described. Compounds for use in the method have the formula ##STR1## in which n is 0 to 5, R is halo, alkyl, trihaloalkyl, cyano alkoxy or alkoxycarbonyl, R.sup.1 and R.sup.2 are each hydrogen, alkyl alkenyl, alkynyl, acyl, or hydrocarbyloxycarbonyl and R.sup.3 and R.sup.4 are each hydrogen or alkyl; or an acid addition. The method is of particular value for controlling ectoparasites which attack cattle and pigs. Certain of the compounds are novel.

Abstract: 1(2)-(N,N-disubstituted carbamoyl)-3,5-substituted-1,2,4-triazoles, with insecticidal and nematicidal properties, are described.

Abstract: Novel 1-carbamoyl-1,2,4-triazoles, processes for their production, and herbicidal compositions and methods are described. The compounds are particularly useful for the pre-weed emergence control of the graminaccous weeds crabgrass, barnyard grass, yellow foxtail and Johnson grass.

Abstract: New fungicidal compounds, and compositions of them and their uses and manufacture are described. The compounds are fungicidal complexes of a metal salt with certain, N,N-disubstituted carbamoyl imidazoles.

Abstract: Pesticidal compositions containing amitraz and a pesticidal tin compound selected from cyhexatin and fenbutatin oxide, are described. The compositions, which preferably comprise the active ingredients in the ratio of 1:10 to 10:1 by weight, are synergistic and have activity against a wide range of insect and acarid pests. They are particularly useful in controlling pests on fruit crops.

Abstract: This invention relates to a container for generally cylindrical tablets which can be used to repeatedly dispense the tablets in pre-determined quantities. The dispenser comprises an outer case and a slidably mounted inner part which together define a container, a dispensing gate, and a downward sloping channel connecting one or two ramps situated at the base of the container to the gate. The width of the channel is such as to allow a single column of tablets supported on their peripheries. The inner part is depressable from the exterior to cause relative movement between the gate and the channel from one position where the gate is in register with the channel to a second position where the gate is in register with a dispenser outlet. The relatively simple design of the dispenser enables it to be injection-moulded from plastic material.

Abstract: New compounds are described which are of value for regulating of plant growth, as well as compositions containing them and methods of using them, are described. The compounds have the formula: ##STR1## in which R.sup.1 and R.sup.2 are each alkyl, alkenyl, alkynyl, cycloalkyl or optionally substituted phenyl or together with the nitrogen atom to which they are attached from a heterocyclic ring, Y is alkyl, alkoxy or halo, n is 0 or an integer 1 to 3, R.sup.3 and R.sup.4 are each methyl or ethyl, and X is one equivalent of an anion.

Abstract: Disclosed is a process for increasing the proportion of a desired enantiomer of a 2-arylpropionic acid which comprises heating at a temperature of at least 80.degree. C. a mixture comprising an inert liquid organic diluent and a salt of the 2-arylpropionic acid with an enantiomer of a chiral organic nitrogenous base, the base and the diluent being such that the salt of the racemic acid has a solubility of 0.1 to 10% w/v in the diluent at the operating temperature and in which process a proportion of the salt is undissolved in the diluent, whereby a proportion of one optical isomer of the acid component of the salt is converted into its enantiomer, and collecting the salt of which the acid component has an increased proportion of that enantiomer.

Abstract: A process is disclosed for preparing arylpropionic acids of formula Ar--CH(CH.sub.3)--COOH, by reacting an aryl Grignard reagent with a metal pyruvate or with a pyruvamide, to form a hydroxy acid of formula Ar--C(OH)(CH.sub.3)--COOH or its amide, and converting the acid or amide to the product.