Patents Assigned to The Carnegie Institution of Washington
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Publication number: 20230416772Abstract: Described herein are methods of modulating seed germination and seed longevity in plants by modifying FLOE1 level or activity; and plants generated by such methods.Type: ApplicationFiled: August 6, 2021Publication date: December 28, 2023Applicants: The Board of Trustees of the Leland Stanford Junior University, Carnegie Institution of WashingtonInventors: Yanniv Dorone, Steven Boeynaems, Aaron D. Gitler, Seung Yon Rhee
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Publication number: 20230373794Abstract: A novel bulk form of 4H-Si, a crystalline allotrope of silicon and a novel method of manufacture. The novel material consists of highly oriented microcrystals of silicon in the 4H structure with no disordered material. The 4H-Si is derived from heating a second novel material Si24 under proper conditions. The allotrope of silicon is produced as bulk, microcrystalline agglomerates.Type: ApplicationFiled: May 23, 2023Publication date: November 23, 2023Applicant: Carnegie Institution of WashingtonInventors: Timothy STROBEL, Thomas SHIELL
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Patent number: 11691890Abstract: The present invention provides carbon-based clathrate compounds, including a carbon-based clathrate compound that includes a clathrate lattice with atoms of at least one element selected from the group consisting of carbon and boron as a host cage structure; guest atoms encapsulated within the clathrate lattice; and, substitution atoms that may be substituted for at least one portion of the carbon and boron atoms that constitute the clathrate lattice. In one embodiment, the invention provides a carbon-based clathrate compound of the formula LaB3C3.Type: GrantFiled: March 5, 2020Date of Patent: July 4, 2023Assignee: Carnegie Institution of WashingtonInventors: Timothy Strobel, Li Zhu
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Publication number: 20230147042Abstract: The present invention provides carbon-based clathrate compounds, including a carbon-based clathrate compound that includes a clathrate lattice with atoms of at least one element selected from the group consisting of carbon and boron as a host cage structure; guest atoms encapsulated within the clathrate lattice; and, substitution atoms that may be substituted for at least one portion of the carbon and boron atoms that constitute the clathrate lattice. In one embodiment, the invention provides a carbon-based clathrate compound of the formula LaB3C3.Type: ApplicationFiled: September 23, 2022Publication date: May 11, 2023Applicant: Carnegie Institution of WashingtonInventors: Timothy STROBEL, Li ZHU
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Publication number: 20210204501Abstract: The disclosure provides compositions and methods for infecting a legume plant and/or increasing the yield of a legume plant by providing a population of light-activated, nitrogen-fixing bacteria by illuminating a population of nitrogen-fixing bacteria with a blue light and delivering to the legume plant the population of light-activated, nitrogen-fixing bacteria.Type: ApplicationFiled: May 24, 2019Publication date: July 8, 2021Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, CARNEGIE INSTITUTION OF WASHINGTONInventors: Winslow BRIGGS, Roberto BOGOMOLNI, Tong-Seung TSENG, Rajnish KHANNA
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Patent number: 10961449Abstract: Nanodiamonds are grown under conditions where diamond-like organic seed molecules do not decompose. This permits engineered growth of fluorescent nanodiamonds wherein a custom designed seed molecule can be incorporated at the center of a nanodiamond. By substituting atoms at particular locations in the seed molecule it is possible to achieve complex multi-atom diamond color centers or even to engineer complete quantum registers. In addition, it is possible to grow ultra-small nanodiamonds, wherein each nanodiamond, no matter how small, can have at least one bright and photostable fluorescent emitter.Type: GrantFiled: April 12, 2017Date of Patent: March 30, 2021Assignees: The Texas A&M University System, Carnegie Institution of WashingtonInventors: Philip Hemmer, Todd Zapata, Viktor Struzhkin, Yingwei Fei
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Publication number: 20200354226Abstract: The present invention provides carbon-based clathrate compounds, including a carbon-based clathrate compound that includes a clathrate lattice with atoms of at least one element selected from the group consisting of carbon and boron as a host cage structure; guest atoms encapsulated within the clathrate lattice; and, substitution atoms that may be substituted for at least one portion of the carbon and boron atoms that constitute the clathrate lattice. In one embodiment, the invention provides a carbon-based clathrate compound of the formula LaB3C3.Type: ApplicationFiled: March 5, 2020Publication date: November 12, 2020Applicant: Carnegie Institution of WashingtonInventors: Timothy STROBEL, Li ZHU
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Patent number: 10466233Abstract: A nanosensor for detecting and quantifying lactate in different types of samples, such as tissues, intra-cellular and subcellular compartments, with high spatial and temporal resolution is disclosed. Methods comprising use of the nanosensor for quantifying the activity of lactate transporters, rates of cellular lactate production and cellular lactate consumption, and rate of mitochondrial pyruvate consumption are also disclosed. Methods for quantifying the transformation in energy metabolism that characterizes cancer cells with single-cell resolution and for detecting interference of candidate drugs with mitochondrial energetics are additionally disclosed.Type: GrantFiled: April 13, 2012Date of Patent: November 5, 2019Assignees: CENTRO DE ESTUDIOS CIENTIFICOS DE VALDIVIA, CARNEGIE INSTITUTION OF WASHINGTONInventors: Luis Felipe Barros Olmedo, Alejandro San Martin, Sebastian Ceballo Charpentier, Wolf B. Frommer
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Patent number: 10358653Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.Type: GrantFiled: January 22, 2016Date of Patent: July 23, 2019Assignees: The Carnegie Institution of Washington, The University of MassachusettsInventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
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Patent number: 10280393Abstract: The present invention relates generally to an integrated system, apparatus and method that allows for the continuous culturing of microorganisms under high pressure conditions and at a wide range of temperatures. More specifically, the system is configured to be gas tight and operate under aerobic or anaerobic conditions. The system is also configured to permit periodic sampling of the incubated organisms under such conditions with minimal physical/chemical disturbance inside the reactor and minimal impacts of shear forces on the collected biomass.Type: GrantFiled: February 27, 2015Date of Patent: May 7, 2019Assignee: CARNEGIE INSTITUTION OF WASHINGTONInventor: Dionysis Ioannis Foustoukos
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Patent number: 10246721Abstract: A novel class of transporter protein, referred to as SWEET, GLUE or Glü, is disclosed. These transporters provide a novel system for the transportation of sugars across membranes within a cell and between the inside and outside of a cell. Such transporters are useful for understanding and altering the sugar concentration within certain organs of an organism, and within certain organelles within the cell. These transporters are also useful in protecting plants from a pathogen attack.Type: GrantFiled: November 10, 2016Date of Patent: April 2, 2019Assignee: Carnegie Institution of WashingtonInventors: Wolf B. Frommer, Sylvie Lalonde
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Patent number: 10179740Abstract: The invention relates to a new phase of silicon, Si24, and a method of making the same. Si24 has a quasi-direct band gap, with a direct gap value of 1.34 eV and an indirect gap value of 1.3 eV. The invention also relates to a compound of the formula Na4Si24 and a method of making the same. Na4Si24 may be used as a precursor to make Si24.Type: GrantFiled: June 30, 2017Date of Patent: January 15, 2019Assignee: CARNEGIE INSTITUTION OF WASHINGTONInventors: Timothy A. Strobel, Duck Young Kim, Oleksandr O. Kurakevych
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Publication number: 20170355605Abstract: The invention relates to a new phase of silicon, Si24, and a method of making the same. Si24 has a quasi-direct band gap, with a direct gap value of 1.34 eV and an indirect gap value of 1.3 eV. The invention also relates to a compound of the formula Na4Si24 and a method of making the same. Na4Si24 may be used as a precursor to make Si24.Type: ApplicationFiled: June 30, 2017Publication date: December 14, 2017Applicant: CARNEGIE INSTITUTION OF WASHINGTONInventors: Timothy A. STROBEL, Duck Young KIM, Oleksandr O. KURAKEVYCH
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Patent number: 9695051Abstract: The invention relates to a new phase of silicon, Si24, and a method of making the same. Si24 has a quasi-direct band gap, with a direct gap value of 1.34 eV and an indirect gap value of 1.3 eV. The invention also relates to a compound of the formula Na4Si24 and a method of making the same. Na4Si24 may be used as a precursor to make Si24.Type: GrantFiled: July 8, 2014Date of Patent: July 4, 2017Assignee: CARNEGIE INSTITUTION OF WASHINGTONInventors: Timothy A. Strobel, Duck Young Kim, Oleksandr O. Kurakevych
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Patent number: 9562081Abstract: A novel class of transporter protein, referred to as SWEET, GLUE or Glü, is disclosed. These transporters provide a novel system for the transportation of sugars across membranes within a cell and between the inside and outside of a cell. Such transporters are useful for understanding and altering the sugar concentration within certain organs of an organism, and within certain organelles within the cell. These transporters are also useful in protecting plants from a pathogen attack.Type: GrantFiled: May 4, 2010Date of Patent: February 7, 2017Assignee: CARNEGIE INSTITUTION OF WASHINGTONInventors: Wolf B. Frommer, Sylvie Lalonde
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Publication number: 20160355835Abstract: The present invention relates to methods of increasing the levels of at least one sugar in developing seeds in a plant, with the methods comprising inserting an exogenous nucleic acid, which codes for at least one sugar transporter protein (SWEET protein), into a plant cell to create a transgenic plant cell, and subjecting the transgenic plant cell to conditions that promote expression of the at least one SWEET protein during seed development. The methods results in transgenic plant seeds, and transgenic plants that produce seed, where the levels of at least one sugar are increased as compared to seeds from non-transgenic plants of the same species grown under the same conditions.Type: ApplicationFiled: March 13, 2014Publication date: December 8, 2016Applicant: CARNEGIE INSTITUTION OF WASHINGTONInventor: Wolf B. Frommer
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Publication number: 20160097088Abstract: Novel methods of ChIP-seq are disclosed herein. These methods of ChIP-seq employ carrier DNA to prevent loss of DNA samples. The greater DNA yields achieved by this invention permit ChIP-seq of a small number of cells, permitting epigenetic analysis of primary cells of limited quantity.Type: ApplicationFiled: September 14, 2015Publication date: April 7, 2016Applicant: Carnegie Institution of WashingtonInventors: Yixian ZHENG, Junling JIA, Xiaobin ZHENG
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Patent number: 9176143Abstract: The disclosure relates to engineered transport proteins comprising at last one fluorescent reporter covalently bound to the transporter protein, wherein the transporter proteins comprise a structural inverted repeat motif, with the motif comprising a first and second subunit that are structural inverted repeats of one another and that are joined to one another by a polypeptide loop.Type: GrantFiled: September 18, 2012Date of Patent: November 3, 2015Assignee: Carnegie Institution of WashingtonInventors: Wolf B. Frommer, Roberto De Michele, Cindy Ast
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Patent number: 9102939Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.Type: GrantFiled: October 8, 2012Date of Patent: August 11, 2015Assignees: The Carnegie Institution of Washington, The University of MassachusettsInventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
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Patent number: 9023306Abstract: The invention relates to a single crystal boron doped CVD diamond that has a toughness of at least about 22 MPa m1/2. The invention further relates to a method of manufacturing single crystal boron doped CVD diamond. The growth rate of the diamond can be from about 20-100 ?m/h.Type: GrantFiled: May 5, 2009Date of Patent: May 5, 2015Assignee: Carnegie Institution of WashingtonInventors: Russell J. Hemley, Ho-Kwang Mao, Chih-Shiue Yan, Qi Liang