Patents Assigned to The Chinese University of Hong Kong
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Patent number: 11944536Abstract: A tricuspid valve apparatus may include a frame and an associated neo-prosthetic valve. The frame acts as a stabilizing structure that extends cephalad into the morphologic or functional right atrium (upstream) and caudally into the morphologic or functional right ventricle (downstream). The frame comprises a strutted atrial dome that conforms to the atrium without obstruction of blood flow from the incoming great veins (i.e. superior vena cava and inferior vena cava) or other anomalous veins and/or tributaries. The frame further comprises ventricular struts to be placed within the right ventricle to secure the neo-prosthetic valve in a desired position. The assembly of the frame and valve is collapsible so that prior to deployment the assembly is placed in a vascular catheter, and then self-expands upon release in the heart.Type: GrantFiled: August 11, 2020Date of Patent: April 2, 2024Assignee: The Chinese University of Hong KongInventors: Erik Yee Mun George Fung, Tze Chuen Ng, Philip Wai Yan Chiu
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Patent number: 11926821Abstract: The quality of cell-free DNA for analysis is improved by techniques described herein. Cell-free DNA may include DNA with defects that do not allow for analysis of those DNA with techniques such as sequencing and targeted capture enrichment. These defects may be defects within the strands of the DNA and not present at the ends of the DNA. These intrastrand defects in cell-free DNA can be repaired. The repair of the defects in cell-free DNA may then allow for these repaired cell-free DNA to be analyzed by techniques, including sequencing and targeted capture enrichment.Type: GrantFiled: October 21, 2019Date of Patent: March 12, 2024Assignee: The Chinese University of Hong KongInventors: Yuk-Ming Dennis Lo, Cheuk Ho Tsang, Peiyong Jiang, Si Long Vong, Rossa Wai Kwun Chiu
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Patent number: 11923046Abstract: Disclosed herein are methods, systems, and apparatus for detecting microamplifications or microdeletions in the genome of a fetus. In some embodiments, the method comprises receiving sequence tags for each of a plurality of DNA fragments in a biological sample; determining genomic positions for the sequence tags; determining whether the density of DNA in each of a plurality of genomic regions is aberrantly high or low; identifying as a microamplification a set of consecutive genomic regions having aberrantly high density; and identifying as a microdeletion a set of consecutive genomic regions having aberrantly low density. The biological sample may be a blood sample obtained noninvasively from a female subject pregnant with the fetus.Type: GrantFiled: February 7, 2020Date of Patent: March 5, 2024Assignee: The Chinese University of Hong KongInventors: Yuk Ming Dennis Lo, Kwan Chee Chan, Peiyong Jiang, Cheuk Yin Jandy Yu, Rossa Wai Kwun Chiu
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Publication number: 20240072848Abstract: A method includes acquiring multiple pieces of first received signal quality information at a receiver, where the multiple pieces of first received signal quality information represent qualities of signals received at the receiver, generating first conditional sample statistical values based on the multiple pieces of first received signal quality information and phase shift arrays corresponding to the signals, determining the first phase shift array that meets a communication requirement according to the first conditional sample statistical values, where the first phase shift array includes the phase shift value for at least one reflective element of an IRS, and configuring the IRS based on the first phase shift array.Type: ApplicationFiled: November 3, 2023Publication date: February 29, 2024Applicants: SHENZHEN RESEARCH INSTITUTE OF BIG DATA, THE CHINESE UNIVERSITY OF HONG KONG, SHENZHEN, HUAWEI TECHNOLOGIES CO., LTD.Inventors: Zhiquan LUO, Kaiming SHEN, Yaowen ZHANG, Shuyi REN, Xin LI, Mingmin WANG, Xin CHEN, Nan ZHANG
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Patent number: 11905521Abstract: The present invention provides novel methods and systems, including cell lines, recombinant polynucleotide constructs, compositions, and kits, for targeted yet universal genomic manipulation.Type: GrantFiled: November 17, 2016Date of Patent: February 20, 2024Assignee: The Chinese University of Hong KongInventors: Bo Feng, Xiangjun He
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Patent number: 11904021Abstract: The subject invention pertains to compositions and methods for making and use of metal-based coated nanoparticles. The metal-based, PEG-coated nanoparticles of the invention comprise folic acid molecules on their surface exercise dual functionality by specifically targeting renal tubule cells and treating renal fibrosis.Type: GrantFiled: October 22, 2021Date of Patent: February 20, 2024Assignee: THE CHINESE UNIVERSITY OF HONG KONGInventors: Chung Hang Jonathan Choi, Cecilia Ka Wing Chan, Yun Wong James Lau
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Patent number: 11905237Abstract: The subject invention pertains to a method of halogenating phenols, yielding a range of halogenated phenols with enantiomeric ratio of up to 99.5:0.5. In certain embodiments, the subject invention pertains to a method of asymmetric halogenation of bisphenol, yielding a range of chiral bisphenol ligands. The novel chiral bisphenols are potent privileged catalyst cores that can be applied to the preparation of ligands for various catalytic asymmetric reactions. The catalyst library can easily be accessed because late-stage modification of the scaffold can readily be executed through cross-coupling of the halogen handles on the bisphenols.Type: GrantFiled: March 25, 2021Date of Patent: February 20, 2024Assignee: The Chinese University of Hong KongInventors: Ying-Yeung Yeung, Xiaodong Xiong, Tianyu Zheng, Xinyan Wang, Ying-Lung Steve Tse
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Patent number: 11898208Abstract: The present invention concerns a method for the detection or monitoring of cancer using a biological sample selected from blood, plasma, serum, saliva, urine from an individual, said method comprising: (a) obtaining DNA from the said biological sample; (b) digesting the DNA sample with one or more methylation-sensitive restriction enzymes; (c) quantifying or detecting a DNA sequence of interest after step (b), wherein the target sequence of interest contains at least two methylation-sensitive restriction enzyme recognition sites; and (d) comparing the level of the DNA sequence from the individual to a normal standard, to detect, prognosticate or monitor cancer.Type: GrantFiled: August 29, 2019Date of Patent: February 13, 2024Assignee: The Chinese University of Hong KongInventors: Yuk-Ming Dennis Lo, Kwan Chee Allen Chan, Chunming Ding
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Patent number: 11884009Abstract: The disclosure relates to a method or a platform for hydrogel-based 3D fabrication, wherein the hydrogel is patterned with a programmable femtosecond light sheet with a power density of 0.1 to 100 TW/cm2.Type: GrantFiled: May 10, 2021Date of Patent: January 30, 2024Assignees: The Chinese University of Hong Kong, Carnegie Mellon UniversityInventors: Shih-Chi Chen, Songyun Gu, Fei Han, Yongxin Zhao, Aleksandra Klimas
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Patent number: 11888454Abstract: A blocking signal cancellation low noise amplifier system includes a first low noise amplifier, a second low noise amplifier, a blocking signal extraction and bias generation circuit, a bias switching circuit, and a bias switching signal generating circuit. The first low noise amplifier is used for dynamic input matching, and the first low noise amplifier receives an input signal and outputs it after amplifying. The blocking signal extraction and bias generation circuit is used to extract a blocking signal from the output signal of the first low noise amplifier, and output a DC voltage signal. The bias switching circuit is used to switch the first low noise amplifier between a blocking mode and a small signal mode. The bias switching signal generating circuit is used to compare the DC bias voltage signal VB2 with a preset reference voltage signal Vref.Type: GrantFiled: July 20, 2021Date of Patent: January 30, 2024Assignee: THE CHINESE UNIVERSITY OF HONG KONG, SHENZHENInventors: Liang Wu, Yifu Li, Xiaoping Wu, Shiyuan Zheng
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Patent number: 11881605Abstract: Provided is an aqueous redox flow battery comprising a positive electrode, a negative electrode, a posolyte chamber containing a posolyte, a negolyte chamber containing a polyoxometalate as a negolyte, and a separator disposed between the posolyte chamber and the negolyte chamber, wherein the polyoxometalate has a conductivity of 65 mS cm?1 or more at ?20° C., and the aqueous redox flow battery has a power density of 250 mW cm?2 or more at ?20° C.Type: GrantFiled: February 25, 2022Date of Patent: January 23, 2024Assignee: The Chinese University of Hong KongInventors: Yi-Chun Lu, Fei Ai
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Patent number: 11873527Abstract: Techniques are provided for detecting hematological disorders using cell-free DNA in a blood sample, e.g., using plasma or serum. For example, an assay can target one or more differentially-methylated regions specific to a particular hematological cell lineage (e.g., erythroblasts). A methylation level can be quantified from the assay to determine an amount of methylated or unmethylated DNA fragments in a cell-free mixture of the blood sample. The methylation level can be compared to one or more cutoff values, e.g., that correspond to a normal range for the particular hematological cell lineage as part of determining a level of a hematological disorder.Type: GrantFiled: August 19, 2020Date of Patent: January 16, 2024Assignee: The Chinese University of Hong KongInventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Kun Sun
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Patent number: 11853387Abstract: A data sparse projection method, includes: randomly initializing a high-dimensional sparse two-dimensional matrix (S1); fixing the high-dimensional sparse two-dimensional matrix, and calculating an optimal output variable by using the high-dimensional sparse two-dimensional matrix (S2); fixing the optimal output variable, and calculating an optimal high-dimensional sparse two-dimensional matrix by using the optimal output variable (S3); and cyclically fixing the high-dimensional sparse two-dimensional matrix and the output variable until the optimal output variable is no longer increased when the high-dimensional sparse two-dimensional matrix is fixed (S4).Type: GrantFiled: April 12, 2023Date of Patent: December 26, 2023Assignee: THE CHINESE UNIVERSITY OF HONG KONG, SHENZHENInventors: Chonglin Gu, Changyi Ma, Wenye Li, Shuguang Cui
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Patent number: 11851675Abstract: The subject invention pertains to methods and devices for generating mature oocytes from immature oocytes and improving oocyte quality for improved success of assistant reproductive technology (ART). The methods include the use of tunneling nanotube-forming cells and oocytes, wherein the tunneling nanotube-forming cells transfer autologous genomic materials, biomolecules and cellular components to the oocytes. The devices of the invention include microfluidic device to improve the efficiency of the transfer of biomolecules and cellular components between tunneling nanotube-forming cells and oocytes.Type: GrantFiled: January 26, 2021Date of Patent: December 26, 2023Assignee: The Chinese University of Hong KongInventors: Tin Lap Lee, Tin Chiu Li, Yiu Leung Chan, Wing Tung Lee, Kin Wing Judy Ng, Ting Hei Thomas Chan
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Patent number: 11851401Abstract: The present disclosure provides a method of preparing unsaturated hydrocarbons by black body photocatalytic (thermal radiative catalytic) conversion of saturated hydrocarbons. In this method, a saturated hydrocarbon reaction gas is introduced into a reaction furnace, and the saturated hydrocarbon is catalyzed to convert under heating and illumination conditions to prepare the unsaturated hydrocarbons. The photocatalysis is combined to the conventional thermal catalysis to improve the catalytic performance, accelerate the reaction speed, increase the conversion rate, and/or improve the selectivity of the catalytic reaction.Type: GrantFiled: October 12, 2022Date of Patent: December 26, 2023Assignees: THE CHINESE UNIVERSITY OF HONG KONG, SHENZHEN, UNIVERSITY OF TORONTOInventors: Lu Wang, Geoffrey Alan Ozin, Zeshu Zhang, Xue Ding, Zhigang Zou
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Patent number: 11845821Abstract: The present disclosure provides a humidity-stiffening polymer material, and a preparation method therefor and a use thereof. The humidity-stiffening polymer material includes the following raw materials: a monomer, an ionic liquid, a salt, a cross-linking agent and an initiator, wherein the monomer includes benzyl methacrylate, the ionic liquid includes an imidazole-based ionic liquid, and the salt includes a hygroscopic salt. The method for preparing the humidity-stiffening polymer material includes: mixing the raw materials to obtain a precursor liquid, performing reaction on the mixture after degassing, and drying the mixture to obtain the humidity-stiffening polymer material. The humidity-stiffening polymer material is applied to actuators, soft robots and wearable biomedical devices based on bionic design.Type: GrantFiled: November 2, 2022Date of Patent: December 19, 2023Assignee: The Chinese University of Hong Kong, ShenzhenInventors: Shiping Zhu, Xiaoqing Ming, Le Yao, Qi Zhang
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Patent number: 11839428Abstract: Disclosed is a method for analyzing a distribution of retinal lesions in a mouse model, including: scanning a mouse posterior polar fundus based on optical coherence tomography (OCT), and acquiring lesion images of the mouse posterior polar fundus; acquiring lesion distribution coordinates based on the lesion images of the mouse posterior polar fundus; constructing a coordinate map of a lesion distribution rule based on the lesion distribution coordinates; and acquiring lesion distribution in quadrants based on the coordinate map of the lesion distribution rule, and calculating and counting a number of lesions in each quadrant.Type: GrantFiled: May 1, 2023Date of Patent: December 12, 2023Assignee: JOINT SHANTOU INTERNATIONAL EYE CENTER OF SHANTOU UNIVERSITY AND THE CHINESE UNIVERSITY OF HONG KONGInventors: Haoyu Chen, Xiaoting Mai, Shaofen Huang, Meiqin Zhang
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Patent number: 11832941Abstract: Disclosed is a method for fabricating a wearable hydrogel glucose sensor, belonging to the technical field of biomedical sensing, including using polyacrylamide hydrogel as a basic material, preparing a hydrogel film by adding with phenylboronic acid group capable of recognizing glucose molecules, and carrying out grating writing on the hydrogel film in a femtosecond laser direct writing mode to obtain the wearable hydrogel glucose sensor. The hydrogel film combines with glucose and expands linearly, which makes the grating period and effective refractive index change. The quantitative measurement of glucose is realized by detecting the spatial position of diffraction band and the change of diffraction power intensity.Type: GrantFiled: December 15, 2022Date of Patent: December 5, 2023Assignee: JOINT SHANTOU INTERNATIONAL EYE CENTER OF SHANTOU UNIVERSITY AND THE CHINESE UNIVERSITY OF HONG KONGInventors: Mingzhi Zhang, Hang Qu, Xuehao Hu, Xin Wen, Qingping Liu
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Patent number: 11820878Abstract: Ultra-stable aqueous foam comprises hydrophobic silica particles residing within bubbles in an aqueous solution of a hydrophilic polymer, a protein, or aqueous dispersible colloidal particles. The combination of the hydrophobic and hydrophilic components stabilizes the foam interfaces to result in long term stability of the foam. The foams can be crosslinked to stable monolithic foams and used for structural foams, coatings, and thermal insulating for construction.Type: GrantFiled: September 21, 2020Date of Patent: November 21, 2023Assignee: The Chinese University of Hong KongInventors: To Ngai, Yifeng Sheng, Kuan Ting Lin
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Patent number: 11807854Abstract: The present invention provides an aptamer that specifically hinds CD44, composition comprising the aptamer, as well as methods for detecting CD44 and for targeted delivery to CD44-expressing cells.Type: GrantFiled: March 14, 2022Date of Patent: November 7, 2023Assignee: The Chinese University of Hong KongInventors: Nathalie Wong, Wing Sze Lo, James Y.W. Lau