Abstract: The present invention provides a method for assessing the risk of cancer in a subject by detecting elevated methylation level in the genomic sequence of the TET1 gene, which leads to suppressed expression of this gene. A kit and device useful for practicing such a method are also provided.

Abstract: Method and apparatus for segmenting a cellular image are disclosed. A specific embodiment of the method includes: acquiring a cellular image; enhancing the cellular image using a generative adversarial network to obtain an enhanced cellular image; and segmenting the enhanced cellular image using a hierarchical fully convolutional network for image segmentation to obtain cytoplasm and zona pellucida areas in the cellular image.

Abstract: A liquid encapsulation device for embedding sensor is provided. The liquid encapsulation device comprises a substrate having an upper surface with a central concave portion; at least one protection layer sealed on the upper surface of the substrate; and at least one sensor fixed on the protection layer. Wherein, the central concave portion is filled with liquid and the sensor is arranged above the central concave portion.

Abstract: The present invention provides for a novel peptide inhibitor and method for treating neurological disorders related to a hexanucleotide (GGGGCC) repeat expansion in the non-coding region of the C9ORF72 gene. Also disclosed are related compositions and kits for therapeutic use in the treatment of the pertinent diseases.

Abstract: Various aspects of a systems and method for place recognition based on a 3D point cloud are disclosed herein. A computer-implemented method for place recognition based on a 3D point cloud, comprising: capturing a 3D point cloud of an area in which the mobile agent is traveling; extracting local features of each point in the captured 3D point cloud; generating a global descriptor of each point of the 3D point cloud using a deep neural network, based on the extracted local features; constructing a place descriptor map of the area based on the generated global descriptors; and recognizing the area by using the generated place descriptor map.

Abstract: The disclosure relates to a complexed iodine-based electrolyte, a redox flow battery comprising the complexed iodine-based electrolyte, and a method for producing the redox flow battery.

Abstract: Size-band analysis is used to determine whether a chromosomal region exhibits a copy number aberration or an epigenetic alteration. Multiple size ranges may be analyzed instead of focusing on specific sizes. By using multiple size ranges instead of specific sizes, methods may analyze more sequence reads and may be able to determine whether a chromosomal region exhibits a copy number aberration even when clinically-relevant DNA may be a low fraction of the biological sample. Using multiple ranges may allow for the use of all sequence reads from a genomic region, rather than a selected subset of reads in the genomic region. The accuracy of analysis may be increased with higher sensitivity at similar or higher specificity. Analysis may include fewer sequencing reads to achieve the same accuracy, resulting in a more efficient process.

Abstract: Embodiments are related to the accurate detection of somatic mutations in the plasma (or other samples containing cell-free DNA) of cancer patients and for subjects being screened for cancer. The detection of these molecular markers would be useful for the screening, detection, monitoring, management, and prognostication of cancer patients. For example, a mutational load can be determined from the identified somatic mutations, and the mutational load can be used to screen for any or various types of cancers, where no prior knowledge about a tumor or possible cancer of the subject may be required. Embodiments can be useful for guiding the use of therapies (e.g. targeted therapy, immunotherapy, genome editing, surgery, chemotherapy, embolization therapy, anti-angiogenesis therapy) for cancers. Embodiments are also directed to identifying de novo mutations in a fetus by analyzing a maternal sample having cell-free DNA from the fetus.

Abstract: Methods, systems, and apparatus determine whether a first chromosomal region exhibits a deletion or an amplification associated with cancer in a sample from a subject (e.g., where the sample includes a mixture of cell-free DNA from tumor cells and non-malignant cells. Nucleic acid molecules of the biological sample are sequenced. Respective amounts of a clinically-relevant chromosomal region and of background chromosomal region(s) are determined from results of the sequencing. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether first chromosomal region exhibits a deletion or an amplification associated with cancer.

Abstract: A dual-mode dielectric resonator using two dissimilar modes is described, the dissimilar modes supported by a ridge waveguide resonator and a ¼-wavelength (¼?) metalized cylindrical resonator within a single, metal-coated dielectric block. Each ridge waveguide resonator and cylindrical resonator form a dual-mode resonator pair. Coupling control posts set between the ridge waveguide resonator and cylindrical resonator can adjust their coupling. Multiple pairs of ridge waveguide/cylindrical resonators are fabricated in the same dielectric block to form a coupled resonator bandpass filter, including an 8-pole or 10-pole dielectric resonator filter, for 5G or other applications. Transmission zeros can be introduced by a metalized blind hole extending vertically between two ridge waveguide resonators or a microstrip extending between two dual-mode resonator pairs between which there exists no partial-width or full-width dielectric window.

Abstract: MRI techniques provide robust imaging in the presence of inhomogeneity in the B1 (RF) and/or B0 magnetic fields. The techniques include using a magnetization prep sequence that includes an adiabatic half passage (AHP) followed by a spin-lock pulse, followed by a reverse AHP, after which a data acquisition sequence can be applied. The AHP and reverse AHP can have amplitude and frequency modulated to sweep through a region of frequency space. The RF amplitude of the AHP and reverse AHP can be designed to be equal to the spin-lock amplitude. Quantification of a magnetization relaxation parameter (e.g., T1rho) can use a modified relaxation model that accounts for relaxation effects during the reverse AHP. A dual-acquisition technique in which the reverse AHP of the second magnetization prep sequence has opposite frequency modulation to the reverse AHP of the first magnetization prep sequence can also be used.

Abstract: Systems and methods for robotic and exoskeleton hands are provided. An exoskeleton hand can include a flexible actuator having a cavity and a reinforcement band. The cavity can be filled with a fluid from a pressure source, forcing the actuator to deform, bend or extend. The fluid that fills the cavity as a driving force can be a gas or liquid, which can be recyclable or disposable.

Abstract: A robotic constructing system based on a cable-driven robot for constructing a structure formed by objects such as bricks is provided. The process of laying the bricks is performed by the cable-driven robot autonomously. The bricks are provided to the robotic constructing system by an external conveyor and a robot arm of the robotic constructing system is configured to pick up the bricks. The robot arm is then configured to place the bricks in a position to receive an adhesive from an adhesive dispenser of the robotic constructing system and further to load the bricks onto a linear rail. The linear rail can be configured to place the bricks within the proximity of the cable-driven robot. The cable-driven robot can be configured to pick up the bricks and lay the bricks in the designated position of a three-dimensional space.

Abstract: The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the REC8 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing REC8 gene expression or activity. Lastly, a highly sensitive and accurate detection method is provided for rapid determination of REC8 gene methylation status.

Abstract: Devices and methods for non-invasive capillary blood pressure measurement are provided. An device can comprise a front end in contact with the body to compress and decompress the capillaries in the tissue, a pressure control module for regulating the contact pressure between the front end and the tissue, a pressure transducer coupled to the front end for measuring the contact pressure, a capillary sensing module for detecting the capillaries pulsations under the contact pressure modulation, and an algorithm for determining the capillaries pressures from the traces of capillary pulsation signals and the contact pressure signal. The methods include an oscillometric method for intermittent arterial and capillary blood pressure measurement and a volume-clamp method for continuous capillary blood pressure measurement.

Abstract: Systems and methods for using determination of base modification in analyzing nucleic acid molecules and acquiring data for analysis of nucleic acid molecules are described herein. Base modifications may include methylations. Methods to determine base modifications may include using features derived from sequencing. These features may include the pulse width of an optical signal from sequencing bases, the interpulse duration of bases, and the identity of the bases. Machine learning models can be trained to detect the base modifications using these features. The relative modification or methylation levels between haplotypes may indicate a disorder. Modification or methylation statuses may also be used to detect chimeric molecules.

Abstract: An optical phased array lidar includes: a laser, for emitting a laser signal; an optical beam splitter, for splitting a laser signal into multiple sub-signals, and distributing them to corresponding optical paths; a phase controller connected to the optical beam splitter, for regulating phases of the multiple sub-signals; an optical antenna array based on a one-dimensional grating structure, connected to the phase controller and for uniformly scattering the phase-regulated sub-signals into free space; and a silicon nitride waveguide array, for transmitting the sub-signals and phase-regulated sub-signals to realize the transmission of near-infrared light and visible light. The optical phased array lidar uses a silicon nitride waveguide array for transmission, thereby realizing the transmission of near-infrared light and visible light. In this way, the lidar can work in the visible light band, thereby broadening the working ranging thereof.

Abstract: The contributions of different tissues to a DNA mixture are determined using methylation levels at particular genomic sites. Tissue-specific methylation levels of M tissue types can be used to deconvolve mixture methylation levels measured in the DNA mixture, to determine fraction contributions of each of the M tissue types. Various types of genomic sites can be chosen to have particular properties across tissue types and across individuals, so as to provide increased accuracy in determining contributions of the various tissue types. The fractional contributions can be used to detect abnormal contributions of a particular tissue, indicating a disease state for the tissue. A differential in fractional contributions for different sizes of DNA fragments can also be used to identify a diseased state of a particular tissue. A sequence imbalance for a particular chromosomal region can be detected in a particular tissue, e.g., identifying a location of a tumor.

Abstract: Method of treating endometriosis and related indications, comprising the administration of Pro-EGCG, a synthetic and derivative product of epigallocatechin-3-gallate [(?)-EGCG]. Use of PRO-EGCG in the manufacture of a medicament for treating endometriosis and related indications. Pro-EGCG for use in the treatment of endometriosis and related indications.

Abstract: Low spherical aberration of a Mikaelian lens makes it suitable for focusing off-optical-axis light propagating in higher order modes. A Mikaelian lens can be used as a mode-size converter to expand light in a semiconductor waveguide before coupling light out of the waveguide. For example, a Mikaelian lens can be used in a waveguide to expand light from a 1 ?m wide multimode waveguide to a 20 ?m wide multimode grating coupler in a shorter distance than an adiabatic taper. 3D FDTD simulation results show that an embodiment of a 12 ?m long, subwavelength mode-size converter has comparable first-order mode transmission as a 600 ?m adiabatic taper.