Abstract: An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in urine is unique to patients with IC. Urine samples from patients who exhibit symptoms consistent with IC are added to the assay system. Binding of APF to the cytoskeletal associated protein 4 (CKAP4) is positive for the presence of APF in urine and diagnostic for IC. The diagnostic system is a significant and surprising advance in diagnosis of IC and has commercial applications relevant to women and men who suffer from symptoms consistent with IC.
Type:
Grant
Filed:
June 6, 2013
Date of Patent:
July 7, 2015
Assignees:
The Commonwealth Medical College, University of Florida Research Foundation, Inc.
Inventors:
David Alan Zacharias, Sonia Lobo Planey
Abstract: An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in urine is unique to patients with IC. Urine samples from patients who exhibit symptoms consistent with IC are added to the assay system. Binding of APF to the cytoskeletal associated protein 4 (CKAP4) is positive for the presence of APF in urine and diagnostic for IC. The diagnostic system is a significant and surprising advance in diagnosis of IC and has commercial applications relevant to women and men who suffer from symptoms consistent with IC.
Type:
Grant
Filed:
December 10, 2009
Date of Patent:
February 24, 2015
Assignees:
The Commonwealth Medical College, University of Florida Research Foundation, Inc.
Inventors:
David Alan Zacharias, Sonia Lobo Planey
Abstract: An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in urine is unique to patients with IC. Urine samples from patients who exhibit symptoms consistent with IC are added to the assay system. Binding of APF to the cytoskeletal associated protein 4 (CKAP4) is positive for the presence of APF in urine and diagnostic for IC. The diagnostic system is a significant and surprising advance in diagnosis of IC and has commercial applications relevant to women and men who suffer from symptoms consistent with IC.
Type:
Application
Filed:
December 10, 2009
Publication date:
October 6, 2011
Applicants:
THE COMMONWEALTH MEDICAL COLLEGE, UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
Inventors:
David Alan Zacharias, Sonia Lobo Planey