Abstract: Polypeptides comprising a cell penetrating amino acid sequence and an interferon regulatory factor 5 (IRF5) targeting amino acid sequence are disclosed, where the IRF5 targeting amino acid sequence is one or more of RHATRHG (SEQ ID NO:1), KSRDFRL (SEQ ID NO:2) and GPRDMPP (SEQ ID NO:3), as well as methods of using these polypeptides to treat diseases, such as autoimmune and inflammatory diseases.
Type:
Application
Filed:
May 4, 2020
Publication date:
July 14, 2022
Applicant:
THE FEINSTEIN INSTITUES FOR MEDICAL RESEARCH
Abstract: Isolated SAA peptides, fusion proteins and compositions comprising such are provided as are domain-specific SAA antibodies. Methods of treating sepsis and endotoxemia are also provided.
Type:
Application
Filed:
September 8, 2016
Publication date:
February 2, 2017
Applicant:
The Feinstein Institue For Medical Research
Inventors:
Haichao Wang, Andrew E. Sama, Wei Li, Kevin J. Tracey