Patents Assigned to The Florida International University Board of Trustees
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Patent number: 11975077Abstract: A cell-penetrating peptide (CPP) comprising a plurality of mono(amino acid)s, oligo(amino acid)s, or poly(amino acid)s where a plurality of the amino acids comprise a positively charged guanylurea unit with a small molecule fragment and each of the mono(amino acid)s, oligo(amino acid)s, or poly(amino acid)s comprising a drug attached through a linker. The CPP can be used for treating cancers.Type: GrantFiled: September 17, 2021Date of Patent: May 7, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventor: Joong Ho Moon
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Patent number: 11976118Abstract: The subject invention provides novel methods for treating B cell malignancies, such as multiple myeloma, using a combination therapy. Said treatment in accordance with the subject invention comprises the administration of a B cell regulator, e.g., a galectin molecule, to a subject suffering from a B cell malignancy, and wherein said subject received, receives, or will receive a treatment with a conventional treatment for such B cell malignancy, e.g., immunotherapy. The administration of the galectin molecule boosts the expression of B cell specific antigens e.g., SLAMF7, on MM cells, thereby increasing the sensitivity of MM cells to anti-SLAMF7 Ab and therapeutic efficacy of Elotuzumab.Type: GrantFiled: July 9, 2021Date of Patent: May 7, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventor: Charles J. Dimitroff
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Patent number: 11974778Abstract: Systems, devices, and methods for implanting target-specific multiple intrafascicular electrodes in peripheral nerves are provided to facilitate an implantation process that can reduce the difficulty of the implanting procedure and the time taken to implement the procedure. A longitudinal intrafascicular electrode implantation facilitator (LIFT) and a method for utilization of the LIFT for intrafascicular electrode implantation are provided. The LIFT can flatten the nerve to increase access to the number of fascicles available for implantation and supports the nerve during electrode implantation.Type: GrantFiled: October 3, 2023Date of Patent: May 7, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Ranu Jung, Anil Thota
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Patent number: 11974972Abstract: The subject invention provides oligo(carbamoylated guanidine)s (OCGs) having fast and selective mycobactericidal effects via disruption of the mycobacterial membrane potential. OCGs also potentiates bedaquiline, an oxidative phosphorylation-targeting anti-TB drug. The combination of OCG and anti-TB drug can be used as an effective therapy for treating tuberculosis.Type: GrantFiled: November 10, 2023Date of Patent: May 7, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Joong Ho Moon, Michelle Miranda
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Publication number: 20240141400Abstract: A method, which synthesizes closed circular single-stranded and double-stranded DNA molecules using in vitro enzymatic systems, is described. Circular single-stranded DNA molecules and double-stranded DNA molecules (e.g., relaxed, or supercoiled) with various sizes can be synthesized. Unwanted DNA molecules, e.g., unligated oligomers, can be removed by exonucleases, such as T5 exonuclease, T7 exonuclease, lambda exonuclease, E. coli exonuclease I and/or III. A method of converting the single-stranded circular DNA molecules into double-stranded circular DNA molecules is also described. The single-stranded and double-stranded circular DNA molecules can be used in a variety of applications.Type: ApplicationFiled: October 25, 2023Publication date: May 2, 2024Applicant: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventor: Fenfei LENG
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Patent number: 11969438Abstract: The present invention provides compositions and methods for selectively treating a cancer or tumor utilizing an effective amount of a vegetable oil-derived polyol or hydrogel particles comprising a vegetable oil-derived polyol. In some embodiments, the cancer is a gynecologic cancer, specifically an ovarian cancer. In other aspects, the present invention provides a method of targeting and imaging various tumors and/or tumor associated macrophages (TAMs).Type: GrantFiled: July 7, 2023Date of Patent: April 30, 2024Assignee: The Florida International University Board of TrusteesInventors: Arti Vashist, Andrea D. Raymond, Prem Chapagain, Madhavan P. Nair, Carolyn D. Runowicz
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Patent number: 11958108Abstract: Methods for large-scale additive manufacturing of high-strength boron nitride nanotubes (BNNT)/aluminum (Al) (e.g., reinforced Al alloy) metal matrix composites (MMCs) (BNNT/Al MMCs), as well as the BNNT/Al MMCs produced by the large-scale additive manufacturing methods, are provided. A combination of ultrasonication and spray drying techniques can produce good BNNT/Al alloy feedstock powders, which can be used in a cold spraying process.Type: GrantFiled: April 6, 2023Date of Patent: April 16, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Arvind Agarwal, Cheng Zhang, Tanaji Paul, Sohail Mazher Ali Khan Mohammed, Denny John
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Patent number: 11958956Abstract: Additive-polymer precursor materials for filaments (e.g., for three-dimensional (3D) printing) are provided, as well as methods of fabricating and using the same. One or more two-dimensional (2D) additive materials (e.g., nano materials, such as nanosheets) can be mixed with a polymer base to give an additive-polymer precursor composite material. The additive material can be dissolved in a first solvent to give an additive solution, and the polymer can be dissolved in a second solvent to give a polymer base. The additive solution can be mixed with the polymer base to give a mixed solution. Solvent casting can then be performed on the mixed solution to evaporate the solvent(s) and give the additive-polymer precursor composite material, which can have a layered structure.Type: GrantFiled: July 21, 2023Date of Patent: April 16, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Daniela Rodica Radu, Cheng-Yu Lai, Melissa Venedicto, Faizan Syed, Dakota Aaron Thomas, Samuel Oyon
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Patent number: 11953492Abstract: Systems and methods are provided to simulate, approximate, or replicate conditions similar to concrete elements being placed under pressures equivalent to several hundred feet of ocean water and to provide information useful to assess relative durability of concrete without coring or other destructive actions. The quality of concrete can be assessed by measuring the pressure drop of water or other liquid to ingress through the concrete surface under high pressure over time. A rapid assessment of quality of existing concrete is provided. Systems and methods can efficiently assess long term durability of existing concrete elements such as those used in midrise buildings, parking garages, bridge decks, and the like.Type: GrantFiled: September 29, 2023Date of Patent: April 9, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Atorod Azizinamini, Amer I. Awwad
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Patent number: 11955268Abstract: Stacked magnetic cores that can achieve high density with a small footprint are provided. A stacked magnetic core can include a plurality of magnetic films with an adhesive film between each magnetic film and the adjacent magnetic film(s). That is, the magnetic films and adhesive films can be disposed in an alternating fashion. Each adhesive film can be a dielectric/insulating film such that each magnetic film is electrically insulated from every other magnetic film.Type: GrantFiled: June 17, 2022Date of Patent: April 9, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Carlos Riera Cercado, Markondeyaraj Pulugurtha, Juan Camilo Gomez, Veeru Jaiswal
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Patent number: 11952395Abstract: The subject invention provides catalytical compounds/complexes, compositions comprising such compound/complex, synthesis of the compounds/complexes, and methods of using such compounds/complexes as catalysts in, for example, RCM reactions. Specifically, the subject invention provides the synthesis of the first catalytically active V oxo alkylidene, VO(CHSiMe3)(PEt3)2Cl, which exhibits superior performance compared to other analogs.Type: GrantFiled: April 7, 2023Date of Patent: April 9, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Konstantin Bukhryakov, Dmitry Belov
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Patent number: 11955673Abstract: Systems and methods for real-time continuous monitoring of fuel cell membrane degradation are provided. At least one microsensor can be used as an inline sensor integrated at the cathode exhaust and/or the anode exhaust of a fuel cell, such as a proton exchange membrane fuel cell (PEMFC)). The microsensor can monitor the PEMFC degradation status by sensing the emission of fluoride.Type: GrantFiled: September 1, 2023Date of Patent: April 9, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Dongmei Dong, Shekhar Bhansali, Tinsley Benhaddouch, Christopher Metler, John Marcial, Justin Fuentes
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Publication number: 20240092812Abstract: The subject invention provides catalytical compounds/complexes, compositions comprising such compound/complex, synthesis of the compounds/complexes, and methods of using such compounds/complexes as catalysts in, for example, RCM reactions. Specifically, the subject invention provides the synthesis of the first catalytically active V oxo alkylidene, VO(CHSiMe3)(PEt3)2Cl, which exhibits superior performance compared to other analogs.Type: ApplicationFiled: April 7, 2023Publication date: March 21, 2024Applicant: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: KONSTANTIN BUKHRYAKOV, DMITRY BELOV
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Patent number: 11936206Abstract: Systems and methods are provided for combined inductive power transfer (IPT) and capacitive power transfer (CPT) to reduce power pulsation in dynamic charging of electric vehicles. Aluminum plates provided between transmitter coils inhibit output power drop, the power pulsation can be reduced, and a constant power profile is provided by operation of CPT system when the receiver is between the IPT coils. As the aluminum plates cover the space between coils, the IPT coils can be separated away from each other by a longer distance compared to conventional segmented coils; therefore, a lesser copper can be used which enhances the cost effectiveness of the provided system. As the respective IPT and CPT system are used alternatively, thus the system's output power can be constant, nearly constant, or effectively constant.Type: GrantFiled: September 29, 2023Date of Patent: March 19, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Arif I. Sarwat, Milad Behnamfar
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Patent number: 11932966Abstract: Filled carbon nanotubes (CNTs) and methods of synthesizing the same are provided. An in situ chemical vapor deposition technique can be used to synthesize CNTs filled with metal sulfide nanowires. The CNTs can be completely and continuously filled with the metal sulfide fillers up to several micrometers in length. The filled CNTs can be easily collected from the substrates used for synthesis using a simple ultrasonication method.Type: GrantFiled: January 6, 2023Date of Patent: March 19, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Wenzhi Li, Yuba Poudel
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Patent number: 11932581Abstract: Foams and methods of fabricating and using the same are provided. The foams can be three-dimensional (3D), free-standing, and/or rigid and can be used as, for example, nanofiller networks. The shape and size of the foam pore interconnected network can be tailorable/tailored. The foams can be, for example, hybrid one-dimensional (1D)/two-dimensional (2D) foams of 1D and 2D materials (e.g., hybrid boron nitride nanotube (BNNT)/boron nitride nanoplatelet (BNNP) foams). A freeze-drying-based method can be used to fabricate bulk porous foam, which can be used for, e.g., nanofiller for polymer nanocomposites.Type: GrantFiled: August 23, 2023Date of Patent: March 19, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Arvind Agarwal, Kazue Orikasa, Tyler Dolmetsch, Tony Thomas
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Patent number: 11929504Abstract: Vertically aligned carbon nanotubes (VACNTs) (e.g., multi-walled VACNTs and methods of synthesizing the same are provided. VACNTs can be synthesized on nickel foam (Ni—F), for example by using a plasma-enhanced chemical vapor deposition (PECVD) technique. A wet chemical method can then be used to coat on the VACNTs a layer of nanoparticles, such as tin oxide (SnO2) nanoparticles.Type: GrantFiled: October 7, 2022Date of Patent: March 12, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Wenzhi Li, Arun Thapa
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Publication number: 20240050469Abstract: Novel dinuclear silver(I) pyrazolido complexes and methods of synthesizing them are provided. Advantageously, the novel silver(I) pyrazolido complexes have excellent antimicrobial activity and methods of using said complexes to treat bacterial, fungal, and viral infections are also provided.Type: ApplicationFiled: October 9, 2023Publication date: February 15, 2024Applicant: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: RAPHAEL G. RAPTIS, INDRANIL CHAKRABORTY, SHAMBHU KANDEL
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Publication number: 20240053291Abstract: The subject invention provides methods for fabricating electrochemical aptamer-based (E-AB) sensors with enhanced sensitivity, signal-to-noise ratios, LOD, and improved stability and reproducibility. The subject invention also provides methods for aptamer immobilization on the surface of the electrode, which favors sufficient spacing between aptamers at the microscale to achieve optimal target recognition, folding, and signal transduction. The E-AB sensors of the subject invention provide superior sensing regardless of the sequence or structure of the bound aptamers or the physiochemical properties of the target.Type: ApplicationFiled: October 23, 2023Publication date: February 15, 2024Applicant: The Florida International University Board of TrusteesInventors: Yi XIAO, Yingzhu LIU, Juan CANOURA
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Patent number: 11897827Abstract: The subject invention provides catalytical compounds/complexes, compositions comprising such compound/complex, synthesis of the compounds/complexes, and methods of using such compounds/complexes as catalysts in, for example, carbon isotope exchange (CIE) on target bioactive molecules. Methods that allow CIE directly on drug candidates are of great importance to chemistry, biology, and medicine. Especially valuable are catalytic procedures that rely on a limited collection of available labeled materials. The instant method comprises converting a methyl group to terminal ?CH2 utilizing transfer dehydrogenation catalysts to enable V-based olefin metathesis, followed by a hydrogenation step. The one-pot strategy allows the formal methylation/demethylation sequence and can be applied to an assortment of alkyl-containing compounds.Type: GrantFiled: May 19, 2023Date of Patent: February 13, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventor: Konstantin Bukhryakov