Abstract: Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of UTRN. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of UTRN. Methods for modulating expression of UTRN using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of UTRN.
Type:
Application
Filed:
May 16, 2013
Publication date:
April 9, 2015
Applicants:
RaNA Therapeutics, Inc., The General Hospital Corporation d/b/a Massachussetts General Hospital
Inventors:
Arthur M. Krieg, Romesh Subramanian, James McSwiggen, Jeannie T. Lee