Abstract: Methods for preparing complex multivalent immunogenic conjugates that include simultaneously reacting a plurality or immunogenic-distinct polysaccharides with at least one protein to make the complex multivalent immunogenic conjugates. The simultaneous reaction involves reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant.
Type:
Application
Filed:
August 6, 2013
Publication date:
February 13, 2014
Applicant:
The Gov't of the U.S.A. as represented by the Secretary of the Dept. of Health & Human Services
Abstract: Methods for venting or drying (e.g., lyophilizing) samples contained in a multi-well plate. One method involves providing a multi-well plate that includes wells that each contain a sample and define an opening substantially sealed with a filter element that permits permeation of at least one gas and substantially prevents permeation of microbes. Another variant includes introducing a sample into a well via an opening defined by the well, covering at least a portion of the well opening with a filter element, and permitting gas to enter or exit the well substantially only through the filter element. An assembly is also described that includes a multi-well plate and a sheet defining a plurality of caps, wherein each of the caps includes a microbe-impermeable filter element. Another multi-well plate assembly includes a filter positioned to extend across at least a portion of the well opening.
Type:
Application
Filed:
September 9, 2002
Publication date:
March 11, 2004
Applicant:
The Gov't of the U.S.A as represented by the secretary of the Dept.of Health and Human Services
Abstract: The present invention is a method of preventing or reducing atherosclerosis or restenosis, and a pharmaceutical preparation used therefor. In particular, it is a method of preventing or reducing atherosclerosis or restenosis after arterial injury by treatment with a low dose of a microtubule stabilizing agent such as taxol or a water soluble taxol derivative. The low dose used in the present invention prevents artery blockage while minimizing any negative side effects associated with the drug.
Type:
Application
Filed:
October 15, 2002
Publication date:
May 29, 2003
Applicant:
The Gov't of the U.S.A. as Represented by the Secretary of the Dept. of Health and Human Service