Abstract: A process for preparing Erianin (Dihydro Combretastation A-4), wherein 3,4,5-trimethoxy benzaldehyde is converted to phosphonium salt or phosphonate ester or the likes thereof, then reacted with isovanillin (3-hydroxyl-4-methoxyl benzaldehyde) including a protected hydroxyl in the 3-position, followed by hydrogenation and deprotection.
Type:
Grant
Filed:
July 12, 2006
Date of Patent:
March 1, 2011
Assignee:
Zhe Jiang Cell Biomedical Research Co., Ltd.
Abstract: This invention relates to a kind of Erianin salt and the preparing process thereof. The said Erianin salt is a compound with the following general formula (I), wherein R is the salt formed by monobasic acid radical of inorganic oxacid combining with metals, ammonium salts, organic amine. This invention also relates to a pharmaceutical composition comprising Erianin salt. Compared with Erianin, the said Erianin salt has far better solubility, which can improve the bioavailability and show better antineoplastic efficacy.
Type:
Application
Filed:
August 1, 2006
Publication date:
December 11, 2008
Applicant:
The Jiang Cell Biomedical Research Co., Ltd.
Abstract: This invention relates to a compound of formula (I), 3,4,5,4?-tetramethoxyl-?,?-diphenylethane-3?-O-sodium sulphate, and its use in the preparation of antineoplastic pharmaceutical.
Type:
Application
Filed:
January 31, 2008
Publication date:
September 25, 2008
Applicant:
The Jiang Cell Biomedical Research Co., Ltd.
Inventors:
Yiping Li, Ning Li, Danping Zhou, Lizuan Chen