Abstract: Provided herein are methods of generating models for prognosing cardiovascular outcomes for monitored subjects infected with an etiologic agent (e.g., severe acute respiratory syndrome coronavirus-2 or another etiologic agent). Related methods, systems, and computer program products are also provided.
Type:
Application
Filed:
December 17, 2021
Publication date:
February 15, 2024
Applicant:
THE JOHNS HOPKINS UNIVERSITY
Inventors:
Julie K. SHADE, Ashish DOSHI, Eric SUNG, Allison HAYS, Natalia A. TRAYANOVA
Abstract: The presently-disclosed subject matter relates to antibodies, compositions, and methods for inhibiting and treating virus infection in the respiratory tract and virus transmission through the respiratory tract. In particular, the presently-disclosed subject matter relates to inhibiting and treating virus infection in a subject using compositions and antibodies that trap viruses in mucus of the respiratory tract, thereby inhibiting transport of virus across or through mucus secretions.
Type:
Grant
Filed:
October 9, 2020
Date of Patent:
February 13, 2024
Assignees:
The University of North Carolina at Chapel Hill, The Johns Hopkins University
Inventors:
Samuel Lai, Ying-Ying Wang, Arthi Kannan, Kenetta Nunn, Durai Babu Subramani, Richard Cone, Bing Yang, Justin Mccallen
Abstract: The presently disclosed subject matter provides compositions and methods for the expression of CRISPR guide RNAs using the H1 promoter. In particular, compositions and methods are provided for the use of the H1 promoter to express CRISPR guide RNA (gRNA) with altered specificity of the 5? nucleotide, as well as use of the H1 promoter sequence as a bidirectional promoter to express Cas9 nuclease and the gRNA simultaneously. Compositions and methods are also provided for the expression and regulation of gRNA expression in vivo through the use of RNA ribozymes and regulatable aptazymes.
Abstract: A system for surgical navigation, including an instrument for a medical procedure attached to a camera and having a spatial position relative to the camera, an x-ray system to acquire x-ray images, and multiple fiducial markers detectable by both the camera and x-ray system, having a radio-opaque material arranged as at least one of a line and a point. A computer receives an optical image from the camera and an x-ray image from the x-ray system, identifies fiducial markers visible in both the optical image and x-ray image, determines for each fiducial marker a spatial position relative to the camera based on the optical image and relative to the x-ray system based on the x-ray image, and determines a spatial position for the instrument relative to the x-ray system based on at least the spatial positions relative to the camera and x-ray system.
Type:
Application
Filed:
December 9, 2021
Publication date:
February 8, 2024
Applicant:
The Johns Hopkins University
Inventors:
Jeffrey H. SIEWERDSEN, Niral M. SHETH, Prasad VAGDARGI, Greg M. OSGOOD, Wathudurage Tharindu DE SILVA
Abstract: An electrostatic probe for positioning an insect specimen is disclosed herein. The electrostatic probe may include an ion generator, a handling end, and a controller. The controller may be configured to: activate the ion generator to produce a electrostatic field at the handling end, wherein the electrostatic field is to attract a specimen to the handling end or hold the insect specimen at the handling end, and discharge the electrostatic field to cause the insect specimen to be released from the handling end.
Type:
Application
Filed:
August 31, 2020
Publication date:
February 8, 2024
Applicant:
The Johns Hopkins University
Inventors:
Laura Elizabeth Schiffrin SCAVO, Adam C. GOODWIN
Abstract: Methods of detecting ZNT8 antibodies in serum are described. The methods include proteoliposomes comprising a transmembrane domain (TMD) and a cytosolic domain (CTD) of ZnT8 proteins exposed on the exterior of the proteoliposome; serum comprising antibodies targeting the ZnT8 proteins; and labelled captured autoantibodies that bind to ZnT8 antibodies.
Type:
Grant
Filed:
July 5, 2018
Date of Patent:
February 6, 2024
Assignees:
The Johns Hopkins University, The Board of Trustees of the Leland Stanford Junior University
Inventors:
Dax Fu, Chengfeng Merriman, Hongjie Dai, Hao Wan
Abstract: Gel polymer electrolyte compositions including a cross-linked three-dimensional polymer network and an electrolyte composition comprising an electrolyte and water are disclosed. The gel polymer electrolyte compositions can be included in an aqueous electrochemical cell, in which a gel polymer electrolyte can be positioned between an anode and a cathode. Methods of forming a gel polymer electrolyte in the form of a film, and methods of forming an aqueous electrochemical cell including a gel polymer electrolyte, are also disclosed.
Type:
Grant
Filed:
April 27, 2020
Date of Patent:
February 6, 2024
Assignee:
The Johns Hopkins University
Inventors:
Konstantinos Gerasopoulos, Bing Tan, Spencer A. Langevin, Matthew W. Logan, Adam W. Freeman
Abstract: Provided are systems, compositions and methods that useful in any setting where generating and tracking light is used. The systems, methods and compositions contain as a component flexible, transparent membrane-based materials that include light emitting diodes (LEDs). The LEDs can include or be formed from colloidal quantum dots (CQDs) as an active layer. The CQDs can be formed from solution-processed semiconductor nanocrystals. They have a tunable band gap energy that can be readily tuned by adjusting the size of the nanocrystals. Transparent membrane-based LED arrays exhibit emission wavelength that can be tuned anywhere in the range of 800-2000 nm. The LEDs are highly transparent in the visible wavelength range with the exception of the CQD active layer. The CQD-based LEDs are components of any device or system wherein generating and/or tracking reflected light is utilized, such as in tracing the location and movement of a living individual, or an inanimate object.
Abstract: A system quantifying clinical skill of a user, comprising: collecting data relating to a surgical task done by a user using a surgical device; comparing the data for the surgical task to other data for another similar surgical task; quantifying the clinical skill of the user based on the comparing of the data for the surgical task to the other data for the other similar surgical task; outputting the clinical skill of the user.
Type:
Application
Filed:
October 10, 2023
Publication date:
February 1, 2024
Applicant:
The Johns Hopkins University
Inventors:
Carol E. REILEY, Gregory D. Hager, Balakrishnan Varadarajan, Sanjeey Pralhad Khudanpur, Rajesh Kumar, Henry C. Lin
Abstract: In one example aspect, a system is disclosed that includes an image capture device; a capillaroscope attachable to the image capture device, the capillaroscope including: a light source configured to provide offset light at an angle and location offset from a center horizontal axis and produce oblique remitted light off a patient site; a reverse lens through which the oblique remitted light passes therethrough; and one or more telescopic lenses through which the remitted light passes therethrough to a lens of the image capture device after passing through the reverse lens.
Abstract: The presently disclosed subject matter provides compositions and methods for administering a nanoparticle or microparticle and a therapeutic agent to the suprachoroidal space in the eye.
Type:
Grant
Filed:
October 2, 2018
Date of Patent:
January 30, 2024
Assignee:
THE JOHNS HOPKINS UNIVERSITY
Inventors:
Peter A. Campochiaro, Jordan Green, Jayoung Kim, Jikui Shen
Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.
Type:
Grant
Filed:
November 15, 2021
Date of Patent:
January 30, 2024
Assignee:
THE JOHNS HOPKINS UNIVERSITY
Inventors:
Yong Du, Kevin H. Leung, Martin Gilbert Pomper
Abstract: A device may obtain field images of a tissue sample, apply, to the field images, spatial distortion and illumination-based corrections (including corrections for photobleaching of reagents) to derive processed field images, identify, in each processed field image, a primary area including data useful for cell or subcellular component characterization, identify, in the processed field images, areas that overlap with one another, and derive information regarding a spatial mapping of cell(s) and/or sub-cellular components of the tissue sample. Deriving the information may include performing segmentation based on the data included in the primary area of each processed field image, and obtaining flux measurements based on other data included in the overlapping areas.
Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.
Type:
Grant
Filed:
January 23, 2023
Date of Patent:
January 16, 2024
Assignee:
The Johns Hopkins University
Inventors:
Alexey Popov, Elizabeth M. Enlow, James Bourassa, Colin R. Gardner, Hongming Chen, Laura M. Ensign, Samuel K. Lai, Tao Yu, Justin Hanes, Ming Yang
Abstract: A cooling device according to the present invention includes a housing configured to accommodate fungi. Warm air enters the housing through an inlet located in the housing. The air flows through the housing, which holds fungi. The air exits the housing and can be driven by an exhaust fan. In some embodiments, a HEPA filter is included to purify the air and prevent dispersal of fungal spores.
Abstract: Disclosed herein are compositions and methods for treating uterine fibroids in vivo, and methods of reducing symptoms associated with uterine fibroids, including pain, bleeding and infertility. The disclosed compositions comprise collagenase in an amount effective to cause shrinkage and/or reduce stiffness of uterine fibroids.
Type:
Grant
Filed:
October 14, 2020
Date of Patent:
January 16, 2024
Assignees:
The Johns Hopkins University, Duke University, BioSpecifics Technologies LLC
Inventors:
James H. Segars, Phyllis Carolyn Leppert, Thomas L. Wegman, Jean-Marie Soma
Abstract: The present invention provides a targeted nanoplex platform for in vivo imaging and theranostic imaging of cancer to simultaneously provide non-invasive assessment of tumor burden and cancer-selective treatments.
Type:
Grant
Filed:
November 23, 2016
Date of Patent:
January 16, 2024
Assignee:
THE JOHNS HOPKINS UNIVERSITY
Inventors:
Ming Li, Ishan Barman, Martin Pomper, Sangeeta Ray
Abstract: The present disclosure is directed to a composition or combination comprising at least one membrane-active peptide, such as melittin, and at least one therapeutic and/or diagnostic agent. Methods of using the membrane-active peptides of the disclosure to open a blood-brain barrier and to deliver a therapeutic and/or a diagnostic agent to a central nervous system (CNS) of a subject in need thereof are also provided.
Type:
Application
Filed:
November 18, 2021
Publication date:
January 11, 2024
Applicant:
THE JOHNS HOPKINS UNIVERSITY
Inventors:
Peter Charles SEARSON, Kalina HRISTOVA, Raleigh LINVILLE, Alexander KOMIN, Piotr WALCZAK
Abstract: A system includes: a phantom object; one or more sensors within the phantom object; and a processor, a computer readable memory, a non-transitory computer readable storage medium associated with a computing device in communication with the phantom object, and program instructions executable by the computing device to cause the computing device to perform operations including: detecting a medical instrument within the phantom object based on sensor data captured by the one or more sensors; measuring a distance between the medical instrument and a target point based on the sensor data; and storing or outputting information identifying the distance between the medical instrument and the target point.
Type:
Application
Filed:
September 28, 2021
Publication date:
January 11, 2024
Applicant:
THE JOHNS HOPKINS UNIVERSITY
Inventors:
Ehsan AZIMI, Peter KAZANZIDES, Zhiyuan NIU