Abstract: The present invention relates to pyrrolo-aromatic heterocyclic compounds, a preparation method therefor and medical use thereof. Particularly, the present invention relates to a compound represented by formula I, a preparation method therefor, a pharmaceutical composition comprising the compound, and use of the compound as a BTK kinase inhibitor. The compound and the pharmaceutical composition comprising same can be used for the treating diseases associated with BTK kinase activity, such as inflammations, autoimmune disorders, and cancers. The definition of each substituent in formula I is the same as that in the description.
Type:
Application
Filed:
December 26, 2017
Publication date:
February 27, 2020
Applicant:
The National Institutes of Pharmaceutical Research and Development (NIP)
Inventors:
Huijun YIN, Xu YAN, Libin ZONG, Weixue TIAN, Li ZHENG, Haoshuai DOU, Yan YANG