Abstract: Tocopheryl succinate derivatives according to formula I: are described. These compounds increase the activity of protein phosphatase 2A, can be included in pharmaceutical compositions, and can be used for the treatment of androgen receptor-dependent cancers such as prostate cancer.

Abstract: A multiple nozzle sprayer that includes a fixed or swing bracket assembly configured with a mounting bracket fixedly or adjustably attached by at least one pivot pin to an outwardly projecting angle arm. The mounting bracket is formed with a mounting pad, and the mounting bracket and the angle arm are each formed with at least one nozzle mounting portion. Also included are first and second nozzles mounted to the nozzle mounting portions and configured to project respective spray clouds to intersect. The first nozzle spray cloud is configured with a predetermined droplet size spectra that is greater than that of the second spray nozzle. The first nozzle can be further configured to spray a cloud of a carrier fluid and the second nozzle can be configured to spray an active fluid in a spray cloud that combines with the carrier fluid spray cloud.