Patents Assigned to The Ohio State Innovation Foundation
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Patent number: 11969210Abstract: Disclosed herein are methods and apparatus for making a determination about an eye comprising detecting light reflected out of an eye of a subject from a retina of the eye of the subject and making a determination about the eye of the subject based upon the reflected light, wherein the light is adjusted for color temperature when making the determination about the eye.Type: GrantFiled: March 10, 2023Date of Patent: April 30, 2024Assignee: Ohio State Innovation FoundationInventor: Melissa Bailey
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Patent number: 11973339Abstract: A T-breaker is an all-in-one solution for dc microgrid fault protection, power flow control, and power quality improvement. A T-breaker features a modular multilevel “T” structure with integrated energy storage devices. The two horizontal arms of the T-breaker realize fault current breaking, load voltage compensation, and power flow control; and the vertical arm of the T-breaker realizes shunt compensation. The configuration provides excellent voltage scalability and relaxes the requirements on the switching signal synchronization during fault transients. The local energy storage in sub-modules eases the fault energy dissipation requirement placed on the traditionally-adopted surge arrestors. The modular multilevel structure also offers immense control flexibility for all types of targeted functions of the provided T-breaker.Type: GrantFiled: June 9, 2021Date of Patent: April 30, 2024Assignee: Ohio State Innovation FoundationInventors: Jin Wang, Risha Na, Yue Zhang
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Patent number: 11969212Abstract: Disclosed herein are methods and apparatus for making a determination about a cataract in an eye in ambient lighting conditions.Type: GrantFiled: February 28, 2023Date of Patent: April 30, 2024Assignee: Ohio State Innovation FoundationInventors: Melissa Bailey, Charles Bosworth
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Patent number: 11965160Abstract: Provided herein are aptamers capable of inhibiting the activity of Von Willebrand Factor (VWF). Pharmaceutical compositions comprising these aptamers are also provided. Methods of preventing blood clot formation in a subject by administering the aptamers are provided and methods of treating a blood clot by administering a VWF-targeting agent are also provided.Type: GrantFiled: January 11, 2021Date of Patent: April 23, 2024Assignees: Duke University, Ohio State Innovation FoundationInventors: Shahid M. Nimjee, Bruce Sullenger, George A. Pitoc, Juliana Layzer
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Patent number: 11967747Abstract: The disclosed technology relates to redox flow batteries (“RFB”), and particularly to electrolytes useful in RFBs based on 2,5-dimercapto-1,3,4-thiadiazole (“DMTD”) and derivatives thereof.Type: GrantFiled: September 14, 2020Date of Patent: April 23, 2024Assignees: The Lubrizol Corporation, Ohio State Innovation FoundationInventors: Shiyu Zhang, Paul E. Adams, Shelby Davis, Christopher Michael Rasik, Madison Tuttle
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Patent number: 11958064Abstract: Various implementations include a fluidic oscillator having at least one control port. The at least one control port is for introducing a control fluid into the fluidic oscillator or suctioning the fluid stream from the fluidic oscillator. The introduction of a control fluid into the fluidic oscillator or suction of the fluid stream from the fluidic oscillator alters the frequency and sweeping angle of the oscillating fluid stream as it exits the fluidic oscillator. Various other implementations include a fluidic oscillator having a first control port defined by the first portion of the outlet nozzle and a second control port defined by the second portion of the outlet nozzle. The introduction of a control fluid into the fluidic oscillator or suction of the fluid stream from the fluidic oscillator through the control ports alters the exit angle of the oscillating fluid stream as it exits the fluidic oscillator.Type: GrantFiled: November 28, 2018Date of Patent: April 16, 2024Assignee: Ohio State Innovation FoundationInventors: Mehmet Tomac, James Gregory
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Patent number: 11953763Abstract: Disclosed herein is a contact lens comprising a rounded, minus-carrier, lenticular-like curve over a central, upper portion of the lens that allows the contact lens to translate upwards in downgaze.Type: GrantFiled: May 26, 2021Date of Patent: April 9, 2024Assignee: Ohio State Innovation FoundationInventors: Melissa D. Bailey, Joseph T. Barr
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Patent number: 11953762Abstract: Disclosed herein is a contact lens comprising a lenticular in a superior portion of the contact lens wherein the contact lens attaches to an upper eyelid of a wearer by the lenticular interacting with an upper tarsal plate of the upper eyelid of a wearer, said interaction allows the contact lens to translate upwards in downgaze and maintain rotational stability. In one aspect, the lenticular has a top surface, said top surface having a shape selected from the group consisting of flat, flat with rounded corners, concave, convex or tapered having a thicker portion closer to an edge of the contact lens, or combinations thereof. In another aspect, the lenticular is comprised of a plurality of lenticular sections. In yet another aspect, the lenticular is anatomically-shaped.Type: GrantFiled: May 26, 2021Date of Patent: April 9, 2024Assignee: Ohio State Innovation FoundationInventors: Melissa D. Bailey, Joseph T. Barr
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Patent number: 11938105Abstract: In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42.Type: GrantFiled: December 19, 2022Date of Patent: March 26, 2024Assignee: Ohio State Innovation FoundationInventors: Ching-Shih Chen, Christopher C. Coss, Samuel Kulp, Yu-Chou Tseng, Tanios Bekaii-Saab
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Patent number: 11932923Abstract: Disclosed are aluminum alloys with high iron content and methods of making and using.Type: GrantFiled: September 29, 2021Date of Patent: March 19, 2024Assignee: Ohio State Innovation FoundationInventors: Alan Luo, Emre Cinkilic, Michael Moodispaw
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Patent number: 11890406Abstract: An example assembly for use with a vacuum system and an esophageal positioning device esophageal positioning device includes an introducer, in which the esophageal positioning device includes a handle, a first segment, a second segment and an articulation driving mechanism. The first segment being coupled to the handle. The second segment being pivotally connected to the first segment. The articulation driving mechanism being configured to pivot the second segment about the first segment upon articulation.Type: GrantFiled: May 9, 2022Date of Patent: February 6, 2024Assignee: Ohio State Innovation FoundationInventors: Veeral M. Oza, Adam Hensel, Emile Daoud, Nishaki Mehta
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Patent number: 11883384Abstract: In one aspect, the disclosure relates to compositions and methods for dispersing exiting Salmonella biofilms and inhibiting formation of Salmonella biofilms. In various aspects, the disclosed compositions can be used in methods of treating a persistent Salmonella infection, including an asymptomatic infection. Such infections can colonize a variety of tissues, including the gall-bladder. Also disclosed are methods of treating typhoid fever. Also disclosed are methods for mitigating or preventing secondary outbreaks of typhoid fever by treating asymptomatic subjects who had been symptomatic for typhoid fever at a previous time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.Type: GrantFiled: June 16, 2022Date of Patent: January 30, 2024Assignees: Ohio State Innovation Foundation, North Carolina State UniversityInventors: John Gunn, Laura Kuo, Christian Melander, William M. Huggins
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Patent number: 11888209Abstract: A multiband antenna comprises a dielectric substrate with a first surface defining an annular ledge and a central recess with a plurality of pockets. A MIMO radiator body is disposed in the central recess having a first surface defining a plurality of lobes which are disposed in respective ones of the plurality of pockets and having a second surface defining an outer rim and a central shelf A radiator ring is disposed at the annular ledge so that the radiator ring and the outer rim converge along an annular gap therebetween. A plurality of MIMO feed lines provide external connection to respective lobes. The MIMO radiator body and the radiator ring provide a substantially horizontally-directed radiation pattern (e.g., for terrestrial signals). At least one low-profile radiator on the central shelf provides a substantially circularly polarized or vertically-directed radiation pattern for receiving signals radiated from a satellite.Type: GrantFiled: November 8, 2022Date of Patent: January 30, 2024Assignees: FORD GLOBAL TECHNOLOGIES, LLC, OHIO STATE INNOVATION FOUNDATIONInventors: John F. Locke, Chi-Chih Chen, Jiukun Che
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Publication number: 20240024394Abstract: The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.Type: ApplicationFiled: June 14, 2023Publication date: January 25, 2024Applicants: Massachusetts Institute of Technology, Ohio State Innovation FoundationInventors: Darrell J. Irvine, Karl Dane Wittrup, Ron Weiss, Yingzhong Li, Noor Momin, Yizhou Dong
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Patent number: 11878046Abstract: Disclosed is a general, reversible bicyclization strategy to increase both the proteolytic stability and cell permeability of peptidyl drugs. A peptide drug is fused with a short cell-penetrating motif and converted into a conformationally constrained bicyclic structure through the formation of a pair of disulfide bonds. The resulting bicyclic peptide has greatly enhanced proteolytic stability as well as cell-permeability. Once inside the cell, the disulfide bonds are reduced to produce a linear, biologically active peptide. This strategy was applied to generate a cell-permeable bicyclic peptidyl inhibitor against the NEMO-IKK interaction.Type: GrantFiled: November 30, 2021Date of Patent: January 23, 2024Assignee: Ohio State Innovation FoundationInventors: Dehua Pei, Ziqing Qian
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Patent number: 11880490Abstract: Systems, methods, and computer program products for controlling use of sensitive data. A heartbeat signal conveying a context identifier is transmitted into areas where access to sensitive data is granted to authorized users. In response to receiving a request to access the sensitive data, access may be granted if the context identifier in the request matches the context identifier in the heartbeat and denied otherwise. If the requestor has exceeded an access threshold, access may be granted at a reduced rate. This reduced rate may be achieved by reducing a rate at which encryption keys are provided to the requestor. An access control layer positioned between an application layer and a communication layer allows the application layer to use plaintext of the sensitive data while protecting the sensitive data as ciphertext in the communication layer.Type: GrantFiled: February 24, 2022Date of Patent: January 23, 2024Assignee: Ohio State Innovation FoundationInventors: Harihara Varma Indukuri, Can Emre Koksal
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Patent number: 11872194Abstract: Disclosed are methods and compositions related to immunoconjugates. Particularly disclosed are immunoconjugates that comprise the Fc portion of IgG3 as well as Factor VII light chain or Factor VII. Also disclosed is an immunoconjugate protein, wherein said immunoconjugate protein comprises a hybrid Fc region of an IgG1 and an IgG3 immunoglobulin conjugated to Factor VII. These immunoconjugates can target Tissue Factor (TF) expressing cells.Type: GrantFiled: March 14, 2018Date of Patent: January 16, 2024Assignee: Ohio State Innovation FoundationInventor: Zhiwei Hu
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Patent number: 11865556Abstract: Various implementations include, an out-of-plane feedback-type fluidic oscillator. including a first portion, a second portion, a middle portion coupled between the first portion and the middle portion, and an axis of rotation. The middle portion includes a first side, a second side opposite and spaced apart from the first side, and a middle plane, an interaction chamber, a fluid supply inlet, an outlet nozzle, a first feedback a channel, and a second feedback channel. The first side is coupled to the first portion, and the second side is coupled to the second portion. The first side, the second side, and the middle plane extend circumferentially around the axis of rotation. The middle plane is disposed equally distanced from the first side and the second side. The fluid stream oscillates as it flows through the interaction chamber such that the fluid stream oscillates as the fluid stream exits the outlet nozzle.Type: GrantFiled: May 28, 2020Date of Patent: January 9, 2024Assignee: Ohio State Innovation FoundationInventors: Mohammad Arif Hossain, Jeffrey P. Bons, James W. Gregory, Ali Ameri
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Patent number: D1013181Type: GrantFiled: April 25, 2022Date of Patent: January 30, 2024Assignees: TegoSens, Inc., Ohio State Innovation FoundationInventors: Abraham Joseph, William T. Abraham, Emre Ertin, Joseph Juratovac, Jeff DeBord, Delano Ellis, Maria Basile, Nathan Stohs, Ian Rawdon
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Patent number: D1019958Type: GrantFiled: April 25, 2022Date of Patent: March 26, 2024Assignees: TegoSens, Inc., OHIO STATE INNOVATION FOUNDATIONInventors: Abraham Joseph, William T. Abraham, Emre Ertin, Joseph Juratovac, Jeff DeBord, Delano Ellis, Maria Basile, Nathan Stohs, Ian Rawdon