Patents Assigned to The Penn State Research Foundation
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Patent number: 12091857Abstract: Embodiments of the disclosure provide a printable cementitious composition comprising a cement binder, an aggregate, at least one pozzolanic additive, an accelerator, water, and nanoclay.Type: GrantFiled: June 21, 2021Date of Patent: September 17, 2024Assignee: THE PENN STATE RESEARCH FOUNDATIONInventors: Ali M. Memari, Maryam Hojati, Jose Manuel Pinto Duarte, Shadi Nazarian, Aleksandra Radlinska, Sven Bilen, Nicholas Meisel
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Patent number: 12076148Abstract: An emotion analysis and recognition system including an automated recognition of bodily expression of emotion (ARBEE) system is described. The system may include program instructions executable by a processor to: receive a plurality of body movement models, each body movement model generated based on a crowdsourced body language dataset, calculate at least one evaluation metric for each body movement model, select a highest ranked body movement model based on the at least one metric calculated for each body movement model, combine the highest ranked body movement model with at least one other body movement model of the plurality of body movement models, calculate at least one evaluation metric for each combination of body movement models, and determine a highest ranked combination of body movement models to predict a bodily expression of emotion.Type: GrantFiled: July 1, 2020Date of Patent: September 3, 2024Assignee: THE PENN STATE RESEARCH FOUNDATIONInventors: James Z. Wang, Yu Luo, Jianbo Ye, Reginald B. Adams
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Patent number: 12076748Abstract: Substrates having a textured surface that can maintain or improve droplet mobility in both the Cassie and Wenzel states include a textured surface and a conformal lubricant layer thereover. The textured surface can include a plurality of raised first elements and a plurality of second elements thereon and the conformal lubricant layer over the plurality of raised first elements and covering the plurality of second elements. The plurality of raised first elements can have an average height of between 0.5 ?m and 500 ?m, and the plurality of second elements can have an average height of between 0.01 ?m and 10 ?m. Such substrates can be prepared by texturing a surface of a substrate with a plurality of raised first elements and a plurality of second elements thereon; optionally silanizing the textured surface and applying a lubricant layer over the plurality of raised first elements and between the plurality of second elements.Type: GrantFiled: August 27, 2019Date of Patent: September 3, 2024Assignee: THE PENN STATE RESEARCH FOUNDATIONInventors: Xianming Dai, Birgitt M. Boschitsch, Jing Wang, Tak-Sing Wong, Nan Sun
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Patent number: 12077478Abstract: Cold sintering of materials includes using a process of combining at least one inorganic compound, e.g., ceramic, in particle form with a solvent that can partially solubilize the inorganic compound to form a mixture; and applying pressure and a low temperature to the mixture to evaporate the solvent and densify the at least one inorganic compound to form sintered materials.Type: GrantFiled: April 9, 2021Date of Patent: September 3, 2024Assignee: The Penn State Research FoundationInventors: Clive A. Randall, Jing Guo, Amanda Baker, Michael Lanagan, Hanzheng Guo
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Patent number: 12064514Abstract: The present invention is directed to peptisomes, including nanopeptisomes, which have a perfluorocarbon liquid core containing a perfluorocarbon liquid and a cargo, such as a therapeutically active agent, dispersed in the perfluorocarbon. liquid, and a plurality of amphiphilic peptide molecules surrounding the perfluorocarbon liquid core, wherein the amphiphilic peptide is represented by Formula (I) HB-CL-HP wherein HB is a fluorinated hydrophobic block, such as a fluorinated hydrophobic amino acid sequence, CL is a cross-linking motif, and HP is a hydrophilic amino acid sequence. The present invention is also directed to methods of use of the amphiphilic peptides and peptisomes, such as nanopeptisomes, to deliver a cargo, such as a therapeutically active agent, to a cell, Q wherein the cell may be in vitro, ex vivo, or in vivo.Type: GrantFiled: July 30, 2018Date of Patent: August 20, 2024Assignees: THE PENN STATE RESEARCH FOUNDATION, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTHInventors: Joel P. Schneider, Scott H. Medina
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Patent number: 12059582Abstract: A method and system of neural stimulation and imaging of nervous system of a subject. The method includes the steps of providing an interface device operable to generate an ultrasonic beam for neuroniodulation and imaging of a targeted neural structure of a subject, implanting the interface device in the subject, and providing and disposing an external coil array over the targeted neural structure of the subject, wherein the external coil array is wirelessly powering and communicating with the interface device.Type: GrantFiled: October 11, 2019Date of Patent: August 13, 2024Assignee: The Penn State Research FoundationInventor: Mehdi Kiani
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Patent number: 12054720Abstract: Provided are compositions and methods for inhibiting transmission of viruses that use mosquitoes as vectors, such as dengue (DENV), Zika (ZIKV) and Chikungunya (CHIKV) viruses. Inhibiting transmission includes reducing viral load of the virus in mosquitoes. The viral load is reduced in mosquitoes that are exposed to the virus by introducing into the mosquitoes or mosquito larvae one or more agents that can participate in RNA interference (RNAi) of expression of one or more mosquito genes, such as alpha-mannosidase 2, or Cadherin87A, or a combination thereof. Also provided are modified mosquitoes or mosquito larvae that comprise the RNAi agents. The modified mosquitoes can be released into a population of unmodified mosquitoes to inhibit transmission of the virus between mammalian hosts. Also provided are compositions comprising an RNAi agent or an expression vector that encodes the RNAi agent for use in the described methods.Type: GrantFiled: August 29, 2019Date of Patent: August 6, 2024Assignee: The Penn State Research FoundationInventors: Suzanne Ford, Elizabeth McGraw
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Patent number: 12051588Abstract: The present invention relates to methods for fabricating vertical homogenous and heterogeneous two-dimensional structures, the fabricated vertical two-dimensional structures, and methods of using the same. The methods demonstrated herein produce structures that are free standing and electrically isolated.Type: GrantFiled: May 3, 2021Date of Patent: July 30, 2024Assignee: The Penn State Research FoundationInventors: Joshua Alexander Robinson, Rafael Vila
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Patent number: 12036515Abstract: The present invention relates to a thin-film composite (TFC) membrane composition comprising macrocycles. The invention also relates in part to a method of fabricating a TFC membrane and to a method of using the TFC membrane to separate a desired liquid or gas from a liquid or gas mixture.Type: GrantFiled: October 2, 2019Date of Patent: July 16, 2024Assignee: THE PENN STATE RESEARCH FOUNDATIONInventors: Manish Kumar, Woochul Song, Yue-xiao Shen, Chao Lang
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Patent number: 12036223Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.Type: GrantFiled: March 21, 2022Date of Patent: July 16, 2024Assignee: THE PENN STATE RESEARCH FOUNDATIONInventors: Joshua E. Allen, Gen Sheng Wu, Wafik S. El-Deiry
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Patent number: 12029008Abstract: A liquid-cooled heat sink has three parts: the water block, the X-clamp, and a copper plate. The water block has an inlet connected to a resin shell. Inside the shell, a fractal inlet manifold divides the inlet coolant flow into several sub streams that eventually exit in the form of uniformly distributed liquid jets through small nozzles/microjets at the bottom of the shell. The union between the shell and the copper plate forms a flood chamber, where the jets impinge on the copper plate, dissipating the heat supplied to the copper plate in contact with the heat source. The warm liquid is removed from the flood chamber through an outlet manifold embedded with the resin shell.Type: GrantFiled: April 13, 2020Date of Patent: July 2, 2024Assignee: The Penn State Research FoundationInventors: Bladimir Ramos Alvarado, Carlos Ulises Gonzalez Valle, Luis Enrique Paniagua Guerra, Jonathan Veli
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Patent number: 12012213Abstract: An electrically powered aerial vehicle includes at least one motor where each motor includes a stator and a rotor, a motor housing having an inlet opening and a discharge opening for airflow, a plurality of rotor blades rotatable by the rotor, each of the plurality of rotor blades having a cavity running from a proximal end of the rotor blade towards a distal end of the rotor blade, and a blade hub coupled to the rotor blades at the proximal end of each rotor blade and coupled to the motor housing at the discharge opening. A chamber is defined in the blade hub and is in fluid communication with the discharge opening of the motor housing and the cavity of each rotor blade. The airflow is centrifugally drawn in from the motor housing through the discharge opening and transported through the chamber and into the cavities of the rotor blades when the rotor blades are rotating.Type: GrantFiled: May 13, 2021Date of Patent: June 18, 2024Assignee: The Penn State Research FoundationInventor: Jose Palacios
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Patent number: 12011191Abstract: The present invention provides fixation devices, locking assemblies, and methods for using the same. The fixation devices of the invention are capable of accurate insertion of medical devices by providing detection means of a patient's internal anatomy and localizing a desired target. The devices are capable of locking into position to maintain accuracy.Type: GrantFiled: January 14, 2021Date of Patent: June 18, 2024Assignee: The Penn State Research FoundationInventors: Sprague W. Hazard, III, Barry Fell, Randy Haluck, Pratik Rohatgi, Peter Dillon
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Patent number: 12005129Abstract: In one aspect, compositions are described herein. In some embodiments, a composition described herein comprises, consists of, or consists essentially of an MRI-active or MRI-sensitive polymer or oligomer formed from (i) a non-alkoxylated and non-alkenoxylated citric acid, citrate, or ester/amide of citric acid, and optionally an alkoxylated or alkenoxylated citric acid, citrate, or ester/amide of citric acid, (ii) a polyol/polyamine such as a diol/diamine, (iii) a monomer comprising an MRI contrast agent, and (iv) an amino acid monomer. The polymer or oligomer may be photoluminescent and MRI-sensitive. In another aspect, imaging methods utilizing the compositions described herein are described. In another aspect, scaffolds, grafts, and films comprising, consisting of, or consisting essentially of the compositions described herein are described.Type: GrantFiled: October 6, 2017Date of Patent: June 11, 2024Assignee: THE PENN STATE RESEARCH FOUNDATIONInventors: Jian Yang, Dingying Shan, Nanyin Zhang
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Patent number: 11997769Abstract: A method of increasing the color gamut of a multi-emitter light emitting device when dimming includes the steps of independently driving each emitter in the device, and increasing the lumen output of at least one emitter while simultaneously decreasing the lumen output of at least one other emitter, such that total color gamut increases while total lumen output of the light emitting device decreases. A light emitting device is also disclosed.Type: GrantFiled: April 25, 2023Date of Patent: May 28, 2024Assignee: The Penn State Research FoundationInventor: Kevin Houser
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Patent number: 11986561Abstract: In one aspect, compositions and wound dressings are described herein. In some embodiments, a composition or wound dressing described herein comprises a mesh formed from a plurality of biodegradable polymer fibers; a first active agent dispersed in the biodegradable polymer fibers; a plurality of biodegradable polymer particles disposed in the mesh; and a second active agent dispersed in the biodegradable polymer particles. The particles can be disposed within the interiors of the fibers of the mesh or between the fibers of the mesh. In another aspect, a composition or wound dressing described herein comprises a first perforated mesh formed from a first plurality of biodegradable polymer fibers; and a second perforated mesh formed from a second plurality of biodegradable polymer fibers, wherein the second perforated mesh is disposed on the first perforated mesh in a stacked configuration and the first and second perforated meshes have different degrees of perforation.Type: GrantFiled: October 12, 2021Date of Patent: May 21, 2024Assignees: THE PENN STATE RESEARCH FOUNDATION, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Jian Yang, Kytai T. Nguyen, Zhiwei Xie
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Patent number: 11987707Abstract: A new class of cost-effective carbon fiber precursors that comprise both hydrocarbon polymer and Pitch structural features in the same polymer structure to exhibit complementary advantages of both PAN- and Pitch-based carbon fiber precursors. The new class of carbon fiber precursors comprise a polymeric pitch copolymer, wherein the polymeric pitch copolymer includes a polymer chain and several pitch polycyclic aromatic hydrocarbon (PAH) molecules grafted or chemically bonded to the polymer chain. Method and processes for the creation of the new class of carbon fiber precursors are also presented, wherein said methods may comprise a thermally-induced coupling and extrusion step.Type: GrantFiled: August 4, 2020Date of Patent: May 21, 2024Assignee: The Penn State Research FoundationInventors: Tze-Chiang Chung, Houxiang Li
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Patent number: 11980502Abstract: A method of performing shear wave elastography in tissue includes transmitting successively a series of ultrasound push pulses in the tissue in a region of interest (ROI) using a single array transducer. The acoustic intensities of the push pulses are sinusoidally modulated with a modulation frequency, Each push pulse generates an acoustic radiation force that pushes the tissue and creates an individual shear wave propagating through the tissue. The amplitudes of the shear waves, and therefore, the displacements produced by the push pulses, are positively proportionally to the intensities of the push pulses. The successively created individual shear waves with different amplitudes sum together to form a continuous, harmonic summed shear wave with a single frequency the same as the modulation frequency of the push pulses.Type: GrantFiled: November 25, 2019Date of Patent: May 14, 2024Assignee: The Penn State Research FoundationInventors: Daniel Humberto Cortes Correales, Che-Yu Lin, Seyedali Sadeghi
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Patent number: 11971377Abstract: The present invention describes a versatile, robust and environmentally controlled platform with a linear temperature gradient for massively parallel chemical or biochemical processing. This apparatus is capable of probing the phase transition behavior of macromolecules in solution, both thermodynamically and kinetically. This includes—but is not limited to—liquid/liquid phase transition behavior of antibody solutions and in situ gelation of thermo-responsive polymers. The device can be operated in a multiplex fashion using a controlled temperature gradient architecture and visualized by dark field microscopy or by other optical intensity measurements.Type: GrantFiled: March 12, 2019Date of Patent: April 30, 2024Assignees: The Penn State Research Foundation, MEDIMMUNE LLCInventors: Tinglu Yang, Bradley Rogers, Jifeng Zhang, Paul S. Cremer
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Patent number: 11958038Abstract: A group of reductive 2D materials (R2D) with extended reactive vacancies and a method for making the R2D with extended reactive vacancies are provided, especially the example of the reductive boron nitride (RBN). To create defects such as vacancies, boron nitride (BN) powders are milled at cryogenic temperatures. Vacancies are produced by milling, and the vacancies can be used to reduce various metal nanostructures on RBN. Due to the thermal stability of the RBN and the enhanced catalytic performance of metal nanostructures, RBN-metals can be used for different catalysts, including electrochemical catalysts and high temperature catalysts.Type: GrantFiled: June 11, 2021Date of Patent: April 16, 2024Assignee: The Penn State Research FoundationInventors: Mauricio Terrones, Yu Lei, He Liu, Kazunori Fujisawa, Ana Laura Elias Arriaga, Tianyi Zhang, Rodolfo Cruz-Silva, Morinobu Endo, Xiaoxing Wang, Cynthia Guerrero-Bermea