Abstract: Method and apparatus for formation of an alloy thin film, or a mixed metal oxide thin film, on a substrate at relatively low temperatures. Precursor vapor(s) containing the desired thin film constituents is positioned adjacent to the substrate and irradiated by light having wavelengths in a selected wavelength range, to dissociate the gas(es) and provide atoms or molecules containing only the desired constituents. These gases then deposit at relatively low temperatures as a thin film on the substrate. The precursor vapor(s) is formed by vaporization of one or more precursor materials, where the vaporization temperature(s) is selected to control the ratio of concentration of metals present in the precursor vapor(s) and/or the total precursor vapor pressure.

Abstract: Hydrogenated amorphous silicon radiation detector devices having enhanced signal are disclosed. Specifically provided are transversely oriented electrode layers and layered detector configurations of amorphous silicon, the structure of which allow high electric fields upon application of a bias thereby beneficially resulting in a reduction in noise from contact injection and an increase in signal including avalanche multiplication and gain of the signal produced by incoming high energy radiation. These enhanced radiation sensitive devices can be used as measuring and detection means for visible light, low energy photons and high energy ionizing particles such as electrons, x-rays, alpha particles, beta particles and gamma radiation. Particular utility of the device is disclosed for precision powder crystallography and biological identification.

Abstract: A process for controlling the glycosylation of protein in a cell wherein the cell is genetically engineered to produce one or more enzymes which provide internal control of the cell's glycosylation mechanism. A Chinese hamster ovary (CHO) cell line is genetically engineered to produce a sialyltransferase. This supplemental sialyltransferase modifies the CHO glycosylation machinery to produce glycoproteins having carbohydrate structures which more closely resemble naturally occurring human glycoproteins.

Abstract: A pattern learning and recognition device. The device includes a parallel processing network for receiving and processing an N-dimensional vector input, and a control system for calculating, and storing output signal correlation information during the learning mode of the device, and for distributing the learned information to the network, in the form of feedback gain, during the pattern-recognition mode of the device. The network is preferably composed of an array of N oscillatory units designed to bifurcate from a rest to an active state when stimulated with a threshold input voltage surge.

Abstract: A switched capacitor pseudo-N-path filter stage includes an analog integrator circuit having an input, an output, and a feedback capacitor connected between the input and the output. A plurality of storage capacitors are connected across the feedback capacitor and an input capacitor is provided. The feedback capacitor and storage capacitors form an analog random access memory. A switching circuit selectively connects the input capacitor across electrical ground and between an input signal and the input of the integrator circuit, and also selectively connects the feedback capacitor and the storage capacitors between electrical ground and the output of the integrator circuit. In this manner, the input signal is filtered as the input capacitor samples the input signal and the charge on the input capacitor is circulated through the feedback capacitor and the storage capacitors.

Abstract: The discovery has been made that coil-to-ground parasitic losses substantially reduce the sensitivity of a nuclear magnetic resonance probe used in nuclear magnetic resonance analyses of lossy dielectic (i.e., relatively conductive) samples, such as biological tissue. A probe circuit is disclosed in which a balancing impedance is inserted for substantially reducing the influence of coil-to-ground parasitics. The probe circuit resulting from the insertion of the balancing impedance markedly increases sensitivity. Concomittantly, the quality factor of the probe circuit and the signal-to-noise ratio of nuclear magnetic resonance signals are substantially improved. The disclosed probe circuit can be incorporated in nuclear magnetic resonance analysis systems where the sample coil is either implanted or placed on the surface of a sample; where the sample coil forms a portion of a large-scale imaging system; or the sample coil is used in a traditional analytical mode with a sample contained in a glass tube.

Abstract: An optically active alpha-amino acid derivative having the formula: ##STR1## wherein: X is OH, Cl, Br, I, or OCOR.sub.3 ;Y is a radical selected to stabilize the alpha carbon atom of the alpha-amino acid derivative sufficiently to prevent significant change in symmetry thereof during replacement of X with an alkyl, aryl, alkenyl, alkynyl, alkaryl, aralkyl, alkenaryl or alkynaryl radical, or such radical having one or more chemical constituents thereon; andR.sub.1 and R.sub.2 are different from one another and are each hydrogen or an alkyl, aryl, alkenyl, alkynyl, alkaryl, aralkyl, alkenaryl, or alkynaryl radical, or such radical having one or more non-protic chemical constituents thereon is conventionally synthesized from the corresponding alpha-amino acid. The ##STR2## portion of the above derivative is converted to a ketone functionality without racemization.

Abstract: An imaging NMR scanner generates multi-dimensional NMR spin echo responses from selected sub-volumes of an object. 90.degree. and 180.degree. r.f. nutation pulses are used together with a variable amplitude gradient between these nutation pulses to phase encode a second dimension in the spin echo response which is already phase-encoded in a first dimension by use of a magnetic gradient during signal readout. Two-dimensional Fourier transforms or multiple angle projection reconstruction processes are then used to generate an array of pixel value data signals representing a visual image of the point-by-point spatial distribution of nutated nuclei within the object. Image artifacts potentially caused by relatively moving elements of the object are avoided by selecting the spin echo generating sub-volumes to avoid the moving elements. High resolution images of sub-volumes of interest can be obtained by selection of a sub-volume of interest in conjunction with these reconstruction techniques.

Abstract: Human lymphoblastoid cell line capable of acting as a fusion partner in the preparation of hybridomas is grown and selected under conditions whereby a cell line is obtained having greatly enhanced fusion efficiency over the parent cell line. The cell line is derived from UC 729 by growing in Iscove's modified serum-free medium with plating at relatively high densities, followed by cloning at limiting dilutions and selecting for high frequency fusion.The subject cell line referred to as WI-L2-729 HF.sub.2 has the A.T.C.C. designation number CRL 8062, having been deposited on Apr. 2, 1981.

Abstract: An imaging NMR scanner obtains plural spin echo signals during each of successive measurement cycles permitting determination of the T2 parameter for each display pixel after but a single measurement sequence. The amplitude of the NMR spin echo responses is dependent on an "a" machine parameter (the elapsed time between initiation of a given measurement cycle and the occurrence of the NMR response) and upon a "b" machine parameter (the elapsed time between initiation of successive measurement cycles). These a and b machine time parameters are selectively controlled to enhance resultant image contrast between different types of tissue or other internal structures of an object under examination. Special phase control circuits ensure the repeatability of relative phasing between successive NMR responses from the same measured volume and/or of reference RF signals utilized to frequency translate and synchronously demodulate the NMR responses in the successive measurement cycles of a complete measurement sequence.

Abstract: A filtration and extraction apparatus comprises a housing, a plurality of cages disposed in a passage of said housing, compressible filtration and extraction mechanisms which are disposable in each cage and mechanisms for simultaneously positioning said cages within the passage and compressing at least a portion of the filtration and extraction mechanisms so as to prevent the channeling of fluid around said filtration and extraction mechanisms.

Abstract: The method of treating mammals including humans in need of a drug having analgesic and/or anti-inflammatory activity comprising the administration of a therapeutically effective amount of manoalide, seco-manoalide or dehydro-seco-manoalide. The anti-inflammatory utility includes acute, chronic and delayed sensitization inflammatory processes.

Abstract: Methods and compositions are provided for gene transfer to intact mammals with expression of the exogenous genetic material in the host. Mammalian host cells which are regenerative, normally highly proliferative or subject to induced proliferation, are transformed or modified in vitro with DNA capable of replication and expression in the host cell, wherein the DNA becomes incorporated into the cell. The modified cells are found to regenerate in the host with expression of the introduced DNA. Particularly, mammalian cells were modified with genes providing for overproduction of a particular enzyme. The modified cells were reintroduced in the host under conditions providing for selective advantage of the modified cells.

Abstract: Hemoflagellates are characterized by restriction endonuclease digestion of the mitochondrial DNA to provide for substantial cleavage of the kDNA network. The resulting electrophoretic profile of the digest can be used as a restriction fingerprint for distinguishing organisms and specific strains. The kDNA is found to be sufficiently stable through numerous passages of the organism to provide a reliable fingerprint.