Patents Assigned to The Regents of the University of Chicago
  • Substituted benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments
    Patent number: 10213416
    Abstract: The present invention relates to substituted benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides substituted benzoxazolone derivatives for use in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: February 26, 2019
    Assignees: The Regents of the University of Chicago, Fondazione Istituto Italiano di Technologia
    Inventors: Daniele Piomelli, Daniela Pizzirani, Anders Bach, Rita Scarpelli, Laurin Melzig, Marco Mor