Abstract: The breakpoints of the pericentric inversion of chromosome 16 have been cloned. Two genes, one at each breakpoint, have also been identified, as well as several forms of the inversion 16 fusion gene. Diagnostic applications for chromosome 16 abnormalities and, particularly acute myeloid leukemia are also within the scope of the present invention.
Type:
Grant
Filed:
November 1, 1996
Date of Patent:
February 9, 1999
Assignees:
The Regents Of The University Of Michigan and The Board of Regents, University of Texas System
Inventors:
Pu Liu, Francis S. Collins, Michael J. Siciliano, David Claxton