Patents Assigned to The Rockefeller University
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Patent number: 11931164Abstract: An optical system for the detection of skin disease, such as melanoma, acquires images of a lesion on a subject's skin at different wavelengths and utilizes a sweeping arm rotating about the lesion in a clock-like sweep to produce diagnostically relevant metrics and classifiers from the image data so as to enhance detection of the skin disease.Type: GrantFiled: January 24, 2023Date of Patent: March 19, 2024Assignee: THE ROCKEFELLER UNIVERSITYInventor: Daniel Gareau
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Patent number: 11918631Abstract: Provided are compositions and methods for selectively reducing the amount of antibiotic resistant and/or virulent bacteria in a mixed bacteria population, or for reducing any other type of unwanted bacteria in a mixed bacteria population. The compositions and methods involve targeting bacteria that are differentiated from other members of the population by at least one unique clustered regularly interspaced short palindromic repeats (CRISPR) targeted DNA sequence. The compositions and methods can be readily adapted to target any bacteria or any bacteria plasmid, or both.Type: GrantFiled: May 20, 2016Date of Patent: March 5, 2024Assignee: THE ROCKEFELLER UNIVERSITYInventors: David Bikard, Luciano Marraffini
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Patent number: 11919945Abstract: This disclosure provides novel broadly neutralizing anti-SARS-CoV-2 antibodies or antigen-binding fragments thereof. The disclosed anti-SARS-CoV-2 antibodies constitute a novel therapeutic strategy in protection against SARS-CoV-2 infections.Type: GrantFiled: November 4, 2021Date of Patent: March 5, 2024Assignee: The Rockefeller UniversityInventor: Michel Nussenzweig
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Patent number: 11897940Abstract: This invention relates to broadly neutralizing and potent anti-HIV-1 antibodies, kits, and methods of use thereof.Type: GrantFiled: March 30, 2022Date of Patent: February 13, 2024Assignees: THE ROCKEFELLER UNIVERSITY, CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Michel Nussenzweig, Natalia T. Freund, Pamela J. Bjorkman, Louise Scharf
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Patent number: 11865094Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.Type: GrantFiled: March 15, 2021Date of Patent: January 9, 2024Assignee: The Rockefeller UniversityInventors: Sohail Tavazoie, Nora Pencheva
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Publication number: 20240002480Abstract: This disclosure provides novel broadly neutralizing anti-tick-borne encephalitis virus (TBEV) antibodies. The disclosed anti-TBEV antibodies represent a novel therapeutic strategy for preventing or treating diseases or infections caused by various tick-borne flaviviruses, including TBEV.Type: ApplicationFiled: November 23, 2021Publication date: January 4, 2024Applicant: The Rockefeller UniversityInventors: Michel Nussenzweig, Davide F. Robbiani
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Patent number: 11827911Abstract: The present description relates to chimeric bacteriophage lysins useful for the identification and/or reduction of staphylococcal populations. For example, a chimeric bacteriophage lysin was engineered and shown to effectively kill all strains of staphylococci tested including antibiotic resistant methicillin-resistant S. Aureus and VISA.Type: GrantFiled: May 24, 2021Date of Patent: November 28, 2023Assignee: The Rockefeller UniversityInventors: Vincent A Fischetti, Anu Daniel, Chad Euler
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Publication number: 20230365661Abstract: The invention provides broadly neutralizing antibodies directed to epitopes of Human Immunodeficiency Virus, or HIV. The invention further provides compositions containing HIV antibodies used for prophylaxis, and methods for diagnosis and treatment of HIV infection.Type: ApplicationFiled: February 22, 2023Publication date: November 16, 2023Applicants: The Rockefeller University, California Institute of TechnologyInventors: Johannes Scheid, Michel Nussenzweig, Pamela J. Bjorkman, Ron Diskin
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Patent number: 11808702Abstract: A multi-photon imaging system includes a laser module having a first channel for outputting a two-photon excitation laser pulse and a second channel for outputting a three-photon excitation laser pulse. The system further includes a first optical path for guiding the two-photon laser pulse from the first channel of the laser module and a second optical path for guiding the three-photon laser pulse from the second channel of the laser module. A microscope is also provided for simultaneously receiving the two-photon laser pulse from the first optical path and the three-photon laser pulse from the second optical path, and simultaneously, or with well controllable delays, delivering the two-photon laser pulse and the three-photon pulse to a target volume. The system further includes a photodetector configured to collect photons generated within the target volume in response to simultaneous excitation of the target volume by both the two-photon laser pulse and the three-photon laser pulse.Type: GrantFiled: January 30, 2020Date of Patent: November 7, 2023Assignee: The Rockefeller UniversityInventors: Alipasha Vaziri, Siegfried Weisenburger
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Publication number: 20230338314Abstract: The invention features methods of treating disorders related to increased levels of myeloid derived suppressor cells such as cancer or infections. The disclosure also provides methods of treating cancer including combinations of LXR? agonists and immunotherapies such as PD1 inhibitors, PDL1 inhibitors, and adoptive T-cell transfer therapy.Type: ApplicationFiled: May 3, 2023Publication date: October 26, 2023Applicant: The Rockefeller UniversityInventors: Sohail Tavazoie, Masoud Tavazoie
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Publication number: 20230338505Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods.Type: ApplicationFiled: May 18, 2023Publication date: October 26, 2023Applicant: The Rockefeller UniversityInventors: Jeffrey V. Ravetch, Taia Wang, Jad Mamaary
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Publication number: 20230331824Abstract: Single-domain antibodies that bind the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) spike protein are disclosed. The single-domain antibodies include binding domains that bind epitopes of the Spike ectodomain inside and outside the receptor binding domain. The single-domain antibodies can be used for multiple purposes including in the research, diagnosis, and prophylactic or therapeutic treatment of COVID-19.Type: ApplicationFiled: August 20, 2021Publication date: October 19, 2023Applicants: The Rockefeller University, Seattle Children's Hospital d/b/a Seattle Children's Research Institute, New York UniversityInventors: Brian T. Chait, Michael P. Rout, John Aitchison, Fred David Mast, Jean Paul Olivier, David Fenyo
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Publication number: 20230295306Abstract: This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.Type: ApplicationFiled: February 22, 2023Publication date: September 21, 2023Applicant: The Rockefeller UniversityInventors: Jeffrey V. Ravetch, Andrew Pincetic
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Patent number: 11760805Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for Fc?RIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.Type: GrantFiled: January 15, 2021Date of Patent: September 19, 2023Assignee: THE ROCKEFELLER UNIVERSITYInventors: Jeffrey V. Ravetch, Rony Dahan
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Publication number: 20230279082Abstract: The present invention relates to anti-HIV antibodies. Also disclosed are related methods and compositions. HIV causes acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies. Since its discovery in 1981, HIV type 1 (HIV-1) has led to the death of at least 25 million people worldwide.Type: ApplicationFiled: April 7, 2023Publication date: September 7, 2023Applicants: The Rockefeller University, California Institute of TechnologyInventors: Hugo Mouquet, Michel Nussenzweig, Pamela J. Bjorkman, Louise Scharf
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Patent number: 11690905Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods.Type: GrantFiled: April 9, 2021Date of Patent: July 4, 2023Assignee: The Rockefeller UniversityInventors: Jeffrey V. Ravetch, Taia Wang, Jad Mamaary
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Patent number: 11674952Abstract: Compositions and methods disclosed concern an isogenic population of in vitro human embryonic stem cells comprising a disease form of the Huntingtin gene (HTT) at the endogenous HTT gene locus in the genome of the cell; wherein the disease form of the HTT gene comprises a polyQ repeat of at least 40 glutamines at the N-terminus of the Huntingtin protein (HTT). The cell lines of the disclosure comprise genetically-defined alterations made in the endogenous HTT gene that recapitulate Huntington's Disease in humans. Furthermore, the cell lines have isogenic controls that share a similar genetic background. Differentiating cell lines committed to a neuronal fate and fully differentiated cell lines are also provided and they also display phenotypic abnormalities associated with the length of the polyQ repeat of the HTT gene. These cell lines are used as screening tools in drug discovery and development to identify substances that fully or partially revert these phenotype abnormalities.Type: GrantFiled: February 24, 2017Date of Patent: June 13, 2023Assignee: The Rockefeller UniversityInventors: Ali Brivanlou, Albert Ruzo, Alessia Deglincerti, Tomomi Haremaki, Fred Etoc
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Publication number: 20230157626Abstract: An optical system for the detection of skin disease, such as melanoma, acquires images of a lesion on a subject's skin at different wavelengths and utilizes a sweeping arm rotating about the lesion in a clock-like sweep to produce diagnostically relevant metrics and classifiers from the image data so as to enhance detection of the skin disease.Type: ApplicationFiled: January 24, 2023Publication date: May 25, 2023Applicant: The Rockefeller UniversityInventor: Daniel GAREAU
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Publication number: 20230152561Abstract: A multiplexing module provided herein is configured to perform operations of receiving a plurality of laser pulses from a pulsed laser source; splitting each laser pulse into a plurality of beamlets; introducing a delay between each adjacent beamlet of the plurality of beamlets, such that the plurality of beamlets associated with a respective laser pulse of the plurality of laser pulses is distributed equally across a pulse repetition period associated with the pulsed laser source; changing a divergence of each subsequent beamlet of the plurality of beamlets associated with each respective laser pulse to introduce a distinguishing feature between each beamlet of the plurality of beamlet to cause each beamlet to focus on a different axial plane or lateral position of the sample; and outputting the plurality of beamlets associated with each respective laser pulse.Type: ApplicationFiled: January 31, 2021Publication date: May 18, 2023Applicant: The Rockefeller UniversityInventors: Alipasha VAZIRI, Jeffrey Dakin DEMAS
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Patent number: 11649276Abstract: The present invention relates to anti-HIV antibodies. Also disclosed are related methods and compositions. HIV causes acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies. Since its discovery in 1981, HIV type 1 (HIV-1) has led to the death of at least 25 million people worldwide.Type: GrantFiled: September 9, 2021Date of Patent: May 16, 2023Assignees: The Rockefeller University, California Institute of TechnologyInventors: Hugo Mouquet, Michel Nussenzweig, Pamela J. Bjorkman, Louise Scharf