Patents Assigned to The Salk Instiute for Biological Studies
  • Nucleic acid process containing improved molecular switch
    Patent number: 5118801
    Abstract: A probe for the detection of a nucleic acid target sequence containing a molecular switch comprising three essential elements: a probe sequence of 20-60 nucleotides surrounded by switch sequences of 10-40 nucleotides which are complementary to each other, wherein the state of the switch is useful for selectively generating a detectable signal if the probe is hybridized to a target; also, assays and kits utilizing such probes.
    Type: Grant
    Filed: September 30, 1988
    Date of Patent: June 2, 1992
    Assignees: The Public Health Research Institute, The Salk Instiute for Biological Studies
    Inventors: Paul M. Lizardi, Fred R. Kramer, Sanjay Tyagi, Cesar E. Guerra, Hilda M. L. Buyoli