Abstract: An ergonomically designed toothbrush having an oversized handle, a shapeable stem, interchangeable, flexible heads of different sizes, bristles arrangements, and geometrical configurations. The handle is generally cylindrical in shape so as to readily fit in the palm of ones hand while having a flattened portion against which the thumb and fingertips may be rested. The handle has attached thereto a rotation means which may be selectively set in a variety of positions about the longitudinal axis of the handle. When a stem with a flexible toothbrush head is attached to the rotation means, the user of the toothbrush may bend the head and set the orientation of the bristles on the head such that they are at a 45.degree.