Patents Assigned to The Trustees of Boston University
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Publication number: 20240131029Abstract: The present disclosure provides methods and compositions for treating a condition associated with impaired lymphatic drainage.Type: ApplicationFiled: February 3, 2022Publication date: April 25, 2024Applicants: President and Fellows of Harvard College, Trustees of Boston UniversityInventors: Esak Lee, Christopher S. Chen
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Patent number: 11965009Abstract: The present invention is a DNA expression vector comprising: a toxP: a mutant toxO that blocks Fe-mediated regulation of gene expression; and a DNA sequence encoding a protein, wherein the toxP and the mutant toxO regulate expression of the DNA segment encoding the protein. It is preferred that DNA expression vectors of the present invention include DNA sequences encoding a signal peptide so that a protein expressed is attached to the signal peptide prior to processing. Novel proteins are produced off of the DNA expression vector of the present invention.Type: GrantFiled: December 13, 2021Date of Patent: April 23, 2024Assignees: The Johns Hopkins University, Trustees of Boston UniversityInventors: William R. Bishai, John R. Murphy, Laurene Cheung, Shashank Gupta, Cynthia K. Bullen
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Publication number: 20240110185Abstract: The methods and compositions described herein are directed to regulated synthetic gene expression systems. In particular, the technology described herein relates to compositions, systems and methods for inducible and transient (e.g., reversible) transcriptional repression of a target transcript of interest (GOI). The methods, compositions and systems described herein relate to engineered synthetic transcription factors (synTF) that are activated by an inducer molecule, which induces the transcription of a repressor or gene editing molecule from a synthetic inducible repressor constructs where the antisense repressor (or gene editing molecule) mediates reversible repression of a target transcript of interest (GOI) in the presence of the inducer.Type: ApplicationFiled: August 15, 2023Publication date: April 4, 2024Applicant: Trustees of Boston UniversityInventors: Michael Howard RAYMOND, Ahmad S. KHALIL
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Publication number: 20240099614Abstract: Disclosed is a hormone electrochemical biosensor, e.g. an amperometric biosensor, for the detection of a hormone and measurement of the concentration of a hormone. The disclosed hormone biosensor comprises a hormone-catalyzing enzyme, such as KSDH1. Also described herein are systems comprising an amperometric biosensor, e.g., chronoamperometric biosensor and methods of using the chronoamperometric biosensor.Type: ApplicationFiled: September 6, 2023Publication date: March 28, 2024Applicant: Trustees of Boston UniversityInventors: James Galagan, Uros Kuzmanovic, Abdurrahman Addokhi
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Patent number: 11940580Abstract: A system for near-surface geophysical subsurface imaging for detecting and characterizing subsurface heterogeneities comprises an instrument that outputs probing electromagnetic signals through a ground surface that interact and are affected by scattered signals of acoustic waves that travel through the ground surface and further senses vibrational modes of a subsurface below the ground surface; an imaging device that dynamically generates a time sequence of images of properties of the acoustic waves and maps elastic wave fields of the acoustic waves; and a processor that analyzes dynamic multi-wave data of the images to quantify spatial variations in the mechanical and viscoelastic properties of the subsurface.Type: GrantFiled: October 10, 2019Date of Patent: March 26, 2024Assignees: Massachusetts Institute of Technology, The Trustees of Boston UniversityInventors: Stephen Brown, Thomas Szabo, Daniel R. Burns, Michael Fehler
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Patent number: 11933864Abstract: A system and method of effectively measuring a change in a gradient of a magnetic field. The systems include a first magnet and a second magnet mechanically coupled together and aligned along a polarization axis. The first magnet and the second magnet are positioned such that a pair of like magnetic poles of the first magnet and the second magnet face in opposite directions. Further, the first magnet and the second magnet are configured to move along the polarization axis in response to a magnetic field. A sensing system is configured to measure a change in a gradient of the magnetic field based on the movement of the first magnet and second magnet along the polarization axis in response to the magnetic field.Type: GrantFiled: May 18, 2023Date of Patent: March 19, 2024Assignee: Trustees of Boston UniversityInventors: Joshua Javor, David Bishop, David Campbell, Matthias Imboden
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Patent number: 11913881Abstract: An example microscope includes a pump laser for providing a first illumination to a sample. A laser array provides a second illumination to the sample. The laser array may include a plurality of laser elements, each providing oblique illuminations to the sample. An illumination collecting source collects the first illumination and the second illumination from the sample. The illumination collecting source may capture transient 3D refractive index (RI) variations in the sample due to the first illumination and second illumination.Type: GrantFiled: January 23, 2023Date of Patent: February 27, 2024Assignee: Trustees of Boston UniversityInventors: Ji-Xin Cheng, JIan Zhao, Lei Tian, Alex Matlock
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Publication number: 20240053264Abstract: A mid-infrared photothermal microscopy system images a sample. A mid-infrared optical source generates a mid-infrared beam which is directed along a first optical path to reach the substrate on a first side and heat the sample. A probe light source generates a probe light which is directed along a second optical path to reach the substrate on a second side and illuminate the sample. A first laser scanner is positioned along the first optical path and configured to rotate to redirect light and scan the sample with the mid-infrared beam. A second laser scanner is positioned along the second optical path and configured to rotate to redirect light and scan the sample with the probe light. The laser scanners each include at least one mirror driven to rotate such that the mid-infrared beam and the probe light scan the sample synchronously.Type: ApplicationFiled: August 15, 2023Publication date: February 15, 2024Applicant: Trustees of Boston UniversityInventors: Ji-Xin Cheng, Lu Lan, Jiaze Yin
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Publication number: 20240041848Abstract: Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The methods can comprise administering to a subject a viral inducing agent with an antiviral agent, and optionally an additional agent. The viral inducing agent can be a HDAC inhibitor administered orally.Type: ApplicationFiled: June 7, 2023Publication date: February 8, 2024Applicant: TRUSTEES OF BOSTON UNIVERSITYInventor: Douglas V. FALLER
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Publication number: 20240035979Abstract: Systems and methods implement of high-speed delay scanning for spectroscopic SRS imaging characterized by scanning a first pulsed beam across a stepwise reflective surface (such as a stepwise mirror or a reflective blazed grating) in a Littrow configuration to generate near continuous temporal delays relative to a second pulsed beam. Systems and methods also implement deep learning techniques for image restoration of spectroscopic SRS images using a trained encoder-decoder convolution neural network (CNN) which in some embodiments may be designed as a spatial-spectral residual net (SS-ResNet) characterized by two parallel filters including a first convolution filter on the spatial domain and a second convolution filter on the spectral domain.Type: ApplicationFiled: August 17, 2023Publication date: February 1, 2024Applicant: Trustees of Boston UniversityInventors: Ji-Xin Cheng, Haonan Lin
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Publication number: 20240036339Abstract: An exemplary illumination source is provided. The illumination source includes a light integrating device for coupling to at least one optical structure at an output port. The light integrating device includes at least one input port. At least one light source produces at least one optical illumination coupled to the at least one input port. A light adjusting tool controls the optical illumination emitted by the light integrating device. The light adjusting tool controls uniformity of light emitted by the light integrating device by modifying at least one internal surface of the light integrating device.Type: ApplicationFiled: July 26, 2023Publication date: February 1, 2024Applicant: Trustees of Boston UniversityInventors: M. Selim Ünlü, Mete Aslan, Iris Celebi, Celalettin Yurdakul, Allison Marie Marn
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Patent number: 11883246Abstract: The inventions provided herein relate to tissue markers and uses thereof, e.g., to mark a target tissue site (e.g., a biopsy site in a breast tissue) or to produce a cell scaffold. The tissue markers described herein are designed to be resistant to fast migration (e.g., immediate migration after implantation through a needle track) and slow migration (e.g., over an extended period of time) upon implantation at a target tissue site (e.g., a biopsy site in a breast tissue), without using an adhesive. Additionally or alternatively, the tissue markers described herein can be readily detectable by at least one imaging modality, e.g., but not limited to magnetic resonance imaging, X-ray imaging, ultrasound imaging, or a combination thereof.Type: GrantFiled: November 21, 2013Date of Patent: January 30, 2024Assignees: TRUSTEES OF BOSTON UNIVERSITY, BOSTON MEDICAL CENTER CORPORATIONInventors: Mark W. Grinstaff, Boris Nicolas Bloch, Jonah Kaplan
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Patent number: 11884653Abstract: Ebola virus and Marburg virus are filoviruses and are responsible for outbreaks that cause up to 90% fatality, including the recent outbreak in West Africa that has resulted in over 11,000 deaths. The present disclosure generally relates to series novel arylnaphthalene compounds, having a formula (I) or a pharmaceutically acceptable salt thereof, as a vacuolar-ATPase inhibitor that are useful for the treatment for a broad spectrum of viral infections, including those infections caused by filoviruses. Pharmaceutical composition matters and methods of use are within the scope of this invention.Type: GrantFiled: April 6, 2021Date of Patent: January 30, 2024Assignees: Purdue Research Foundation, Trustees of Boston UniversityInventors: Vincent Jo Davisson, Aaron Raymond Lindstrom, Naoaki Fujii, Robert A. Davey
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Patent number: 11883344Abstract: An example photoacoustic system for neurostimulation includes a light producing device for producing light of a specific wavelength. At least one nanotransducer is binded on a surface of a neuron. The nanotransducer converts the light with the specific wavelength into at least one acoustic wave at or near the neuron.Type: GrantFiled: January 30, 2023Date of Patent: January 30, 2024Assignee: Trustees of Boston UniversityInventors: Chen Yang, Ji-Xin Cheng
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Publication number: 20240027655Abstract: An exemplary imaging system is provided. The imaging system includes a light source configured to illuminate a plurality of spatially separated regions of a material structure producing a first illumination. A lens produces an image of the spatially separated regions. A lens array magnifies the spatially separated regions of the image. The lens array produces a mosaic image comprised of magnified subimages of each region spatially separated region. A camera sensor to record the image.Type: ApplicationFiled: July 18, 2023Publication date: January 25, 2024Applicants: Trustees of Boston University, Massachusetts Institute of TechnologyInventors: Thomas Bifano, Jerome Mertz, Marshall Ma, Devin Beaulieu
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Publication number: 20240024505Abstract: The disclosure relates generally to methods and compositions for generation or enhancement of partial or complete cellular signaling pathwaysType: ApplicationFiled: July 12, 2023Publication date: January 25, 2024Applicant: Trustees of Boston UniversityInventors: Mark W. Grinstaff, Jack R. Kirsch, Amanda K. Williamson, Brett Tingley
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Patent number: 11878057Abstract: Provided herein are lipid A molecules engineered from Moritella lipopolysaccharides and uses thereof.Type: GrantFiled: December 10, 2021Date of Patent: January 23, 2024Assignees: TRUSTEES OF BOSTON UNIVERSITY, THE CHILDREN'S MEDCIAL CENTER CORPORATION, MINISTRY OF FISHERIES AND MARINE RESOURCES DEVELOPMENTInventors: Randi Dawn Rotjan, Anna Gauthier, Aranteiti Tekiau, Jonathan C. Kagan
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Publication number: 20240019369Abstract: An example microscope includes a pump laser for providing a first illumination to a sample. A laser array provides a second illumination to the sample. The laser array may include a plurality of laser elements, each providing oblique illuminations to the sample. An illumination collecting source collects the first illumination and the second illumination from the sample. The illumination collecting source may capture transient 3D refractive index (RI) variations in the sample due to the first illumination and second illumination.Type: ApplicationFiled: January 23, 2023Publication date: January 18, 2024Applicant: Trustees of Boston UniversityInventors: Ji-Xin Cheng, Jian Zhao, Lei Tian, Alex Matlock
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Patent number: 11874343Abstract: A gradiometer includes a at least one magnet attached to a beam. The magnet moves in response to a magnetic force. A sensing element is configured to measure movement or deflection of the beam or magnet. The gradiometer is configured to determine a gradient of a magnetic field acting on the first magnet based on movement of the magnet. The gradiometer can further measure higher order gradients.Type: GrantFiled: February 21, 2023Date of Patent: January 16, 2024Assignee: Trustees of Boston UniversityInventors: Joshua Javor, David Bishop, David Campbell, Matthias Imboden
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Publication number: 20240011990Abstract: The systems, methods, devices and kits disclosed herein be used to determine the presence and/or level a target analyte(s) in a biological sample, wherein the analyte(s) is associated with a pathogenic (e.g., a viral antigen or whole virus) or otherwise altered physiological condition (e.g., pregnancy). In certain embodiments, the systems, methods, devices and kits provide one or more improved properties relative to the RT-PCT and lateral flow antibody assays known in the art for the detection of SARS-CoV-2, including but not limited to, assay time, ease of use, risk of infection, accuracy, specificity, selectivity, limit of detection of the assay, quantitative detection and the effect of common interferents to the sensor output, cost, simplicity or a combination thereof.Type: ApplicationFiled: July 16, 2021Publication date: January 11, 2024Applicant: TRUSTEES OF BOSTON UNIVERSITYInventors: Karthika SANKAR, Scott SCHAUS, James GALAGAN, Catherine KLAPPERICH, John CONNOR, Mark GRINSTAFF, Keith HEARON