Patents Assigned to The Trustees of Columbia University in City of New York
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Publication number: 20240150297Abstract: The present invention provides a compound having the structure: wherein X1 is N or CR5, wherein R5 is H, OH, halogen or alkyl; X2, X3 and X4 are each independently NH, N, S, O or CR6, wherein each R6 is independently H, OH, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, haloalkyl, —O—(alkyl), —S—(alkyl), —NH2, —NH—(alkyl), —N(alkyl)2 or —CO2H; R1, R2, R3 and R4 are each independently —H, —F, —Cl, —Br, —I, —NO2, —CN, —CF3, —CF2H, —OCF3, -(alkyl), -(haloalkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(cycloalkyl), -(cycloalkylalkyl), -(heteroalkyl), heterocycle, heterocycloalkyl, -(alkylheteroalkyl), -(alkylaryl), —OH, —OAc, —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), (heteroaryl), —SH, —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), —S-(heteroaryl), —NH2, —NH-(alkyl), —NH-(alkenyl), —NH-(alkynyl), —NH-(aryl), —NH-(heteroaryl), —C(O)R7, —S(O)R7, —SO2R7, —NHSO2R7, —OC(O)R7, —SC(O)R7, —NHC(O)R7 or —NHC(S)R7, wherein R7 is, H, —(alkyl), —OH, —O(alkyl), —NH2, —NH(alkyl)Type: ApplicationFiled: February 10, 2022Publication date: May 9, 2024Applicants: The Trustees of Columbia University in the City of New York, Albany College of Pharmacy and Health Sciences in the City of AlbanyInventors: Konstantin Petrukhin, Boglarka Racz, Andras Varadi, Christopher : Cioffi, Parthasarathy Muthuraman, Arun Raja
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Publication number: 20240150372Abstract: The present invention provides a method of treating a subject afflicted with a substance use disorder (SUD) comprising administering to the subject an effective amount of a compound having the structure: wherein A is a ring structure, with or without substitution; X1 is C or N; X2 is N, O, or S; Y1 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y2 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y3 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y4 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y5 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y6 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); ? and ? are each prType: ApplicationFiled: February 17, 2022Publication date: May 9, 2024Applicants: The Trustees of Columbia University in the City of New York, High Point UniversityInventors: Dalibor Sames, Vaclav Havel, Scott Hemby
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Patent number: 11975290Abstract: A process, composition, and apparatus for carbon dioxide (CO2) sequestration are disclosed. The process includes passing air containing the CO2 through a cyclopropeneimine (CPI)-functionalized material. The composition includes a CPI-functionalized material that reacts with CO2 when mixed with air containing the CO2. The apparatus includes a component for providing a CPI-functionalized material and mixing the material with CO2 gas.Type: GrantFiled: March 17, 2022Date of Patent: May 7, 2024Assignees: International Business Machines Corporation, The Trustees of Columbia University in the City of New YorkInventors: James L. Hedrick, Nathaniel H. Park, Luis M. Campos, Dino Wu, Daniel Malinowski
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Publication number: 20240138918Abstract: Certain embodiments include a method for assisting a clinician in performing a medical procedure on a patient using augmented reality guidance. The method can include obtaining a three-dimensional model of an anatomic part of the patient. The method can also include aligning the three-dimensional model with data to form augmented reality guidance for the medical procedure. In addition, the method can include presenting the augmented reality guidance to the clinician during the medical procedure using an augmented reality three-dimensional display.Type: ApplicationFiled: May 22, 2023Publication date: May 2, 2024Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Steven Feiner, Gabrielle Loeb, Alon Grinshpoon, Shirin Sadri, Carmine Elvezio
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Patent number: 11968974Abstract: Described are systems, methods, and devices relating to normothermic extracorporeal support of an organ, tissue, or bioengineered graft comprising cross-circulation (XC) perfusion for prolonged periods (days to weeks) via an XC perfusion circuit in connection with an extracorporeal host (e.g., animal, patient, organ transplant recipient) are disclosed. The XC perfusion circuit comprises auto-regulation of blood flow based on the trans-organ blood pressure difference between arterial and venous pressure. Recipient support enabled 36 h of normothermic perfusion that maintained healthy lungs with no significant changes in physiologic parameters and allowed for the recovery of injured lungs. Extended support enabled multiscale therapeutic interventions in all extracorporeal lungs. Lungs exceeded transplantation criteria.Type: GrantFiled: January 10, 2019Date of Patent: April 30, 2024Assignee: The Trustees of Columbia University in the City of New YorkInventors: Matthew Bacchetta, Scott Chicotka, Kenmond Fung, Brandon Guenthart, John O'Neill, Gordana Vunjak-Novakovic
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Patent number: 11973490Abstract: A non-reciprocal filter with parametric amplification to obtain non-reciprocal propagation of forward and reverse signals is disclosed. The non-reciprocal filter may include two asymmetrical transmission lines and a current source. The filter, when implemented in the acoustics domain using surface acoustic waves (SAW), may operate in a phase-coherent or a phase-incoherent degenerate mode, providing low insertion loss and high decibels of isolation.Type: GrantFiled: January 15, 2021Date of Patent: April 30, 2024Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Jose Antonio Bahamonde, Ioannis Kymissis
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Publication number: 20240125862Abstract: Disclosed are systems, methods, and other implementations, including a method for monitoring and managing battery performance that includes deriving a representation of diffusion overpotential behavior for a lithium-ion battery according to a discrete-time state-space approximation of a convolution-defined diffusion (CDD) model for the lithium-ion battery, and determining behavior of the lithium-ion battery according to the discrete-time state-space approximation of the convolution-defined diffusion (CDD) model for the lithium-ion battery.Type: ApplicationFiled: October 4, 2023Publication date: April 18, 2024Applicant: The Trustees of Columbia University in the City of New YorkInventors: Alan Gen Li, Matthias Preindl
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Patent number: 11957656Abstract: The present invention relates to methods for regulating prohormone convertase (PC1) and compounds and treatments which increase PC1 levels, for treating Prader-Willi Syndrome (PWS).Type: GrantFiled: October 26, 2020Date of Patent: April 16, 2024Assignees: The Trustees of Columbia University in the City of New York, Levo Therapeutics, Inc.Inventors: Lisa Cole Burnett, Dieter Egli, Rudolph L Leibel, Sara Cotter
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Patent number: 11957622Abstract: The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage, by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of the tissue being treated. In an embodiment, the femtosecond laser operates in the infrared frequency range.Type: GrantFiled: January 12, 2023Date of Patent: April 16, 2024Assignee: The Trustees of Columbia University in the City of New YorkInventors: Sinisa Vukelic, Gerard A. Ateshian
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Patent number: 11959137Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.Type: GrantFiled: August 9, 2022Date of Patent: April 16, 2024Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Jingyue Ju, Xiaoxu Li, Xin Chen, Zengmin Li, Shiv Kumar, Shundi Shi, Cheng Guo, Jianyi Ren, Min-Kang Hsieh, Minchen Chien, Chuanjuan Tao, Ece Erturk, Sergey Kalachikov, James J. Russo
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Patent number: 11961533Abstract: Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method comprising obtaining, by a device, a combined sound signal for signals combined from multiple sound sources in an area in which a person is located, and applying, by the device, speech-separation processing (e.g., deep attractor network (DAN) processing, online DAN processing, LSTM-TasNet processing, Conv-TasNet processing), to the combined sound signal from the multiple sound sources to derive a plurality of separated signals that each contains signals corresponding to different groups of the multiple sound sources. The method further includes obtaining, by the device, neural signals for the person, the neural signals being indicative of one or more of the multiple sound sources the person is attentive to, and selecting one of the plurality of separated signals based on the obtained neural signals. The selected signal may then be processed (amplified, attenuated).Type: GrantFiled: May 27, 2022Date of Patent: April 16, 2024Assignee: The Trustees of Columbia University in the City of New YorkInventors: Nima Mesgarani, Yi Luo, James O'Sullivan, Zhuo Chen
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Publication number: 20240121845Abstract: Method for unified networking for a device in heterogeneous mobile environments includes maintaining and monitoring active network interfaces, managing the location of the device, managing network access security, enabling disruption tolerance support for applications, enabling service sharing and session mobility, managing system parameters for one or more active application sessions, managing storage functionality in one or more memory devices, and maintaining a mapping for one or more flows corresponding to the one or more active application sessions, maintaining one or more policies, and performing flow control decisions based upon the policies using a policy engine. The method can also include monitoring for network events, evaluating whether to perform a handover based upon policies, and providing seamless secure handovers in a heterogeneous mobile environment. A device, non-transitory computer-readable medium, and a system for unified networking are also provided.Type: ApplicationFiled: December 15, 2023Publication date: April 11, 2024Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Amandeep SINGH, Gaston S. ORMAZABAL, Henning G. SCHULZRINNE
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Publication number: 20240115987Abstract: A dual function material is provided that captures carbon dioxide from ambient air, i.e., direct air capture, and converts the CO2 to a desired product such as methane. The material includes a high surface area carrier such as Al2O3 upon which catalysts and alkaline adsorbents are positioned proximate each other. In the presence of reactive gas such as hydrogen, the catalysts reduce the adjacent adsorbents to generate additional active sites and enhance the amount of CO2 captured by the material. Once the material becomes saturated with CO2, hydrogen is reintroduced to reduce the catalyst, such as ruthenium, at which time the adsorbed CO2 can migrate from the adsorbent to the catalyst for catalytic conversion to methane. The materials can be employed in isothermal, cyclic reactor systems where target species are bound and then desorbed to reactivate the material, e.g., bind more target species for desorption and/or conversion to additional product.Type: ApplicationFiled: December 1, 2023Publication date: April 11, 2024Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Chae JEONG-POTTER, Martha ARELLANO-TREVINO, Robert J. FARRAUTO
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Patent number: 11952416Abstract: Anti-annexin A1 antibodies are provided and methods of treating FAP and cancer using Anti-annexin A1 antibodies, antibody fragments or fusion proteins, including bispecific antibodies targeting two different annexin A1 epitopes, are also provided.Type: GrantFiled: September 14, 2023Date of Patent: April 9, 2024Assignee: The Trustees of Columbia University in the City of New YorkInventor: Yiping Han
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Publication number: 20240110931Abstract: The present disclosure relates to delta-2-tubulin and its use as a biomarker for determining if a subject is at risk of developing peripheral neuropathy or if a subject has developed peripheral neuropathy. The present disclosure further relates to methods for the treatment of peripheral neuropathy in a subject and assays for identifying compounds that can be used to treat and/or prevent peripheral neuropathy.Type: ApplicationFiled: December 5, 2023Publication date: April 4, 2024Applicants: The Trustees of Columbia University in The City of New York, Università Degli Studi Di Milano-BicoccaInventors: Francesca Bartolini, Maria Elena Pero, Guido Cavaletti
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Publication number: 20240109836Abstract: The present invention provides a compound having the structure: wherein R1 is —(C2-C12 alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl); R2 is H, halogen, —NO2, —CN, —CF3, —CF2H, —CH2OCH3, —CF2CH3, —CF2OCH3, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(cycloalkylalkyl), -(heteroalkyl), -(heterocycle), -(heterocycloalkyl), -(aryl), -(heteroaryl), -(hydroxyalkyl), -(haloalkyl), -(alkylaryl), —OH, —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(haloalkyl), —O-(aryl), —O-(heteroaryl), —OCF3, SH, —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), —S-(heteroaryl), —NH2, —NH-(alkyl), —NH-(alkenyl), —NH-(alkynyl), —N-(alkyl)2, NH-(aryl), —NH-(heteroaryl), —CO2H, —CO2-(alkyl), —C(O)—NH2, —C(O)—NH-(alkyl), —C(O)—NH-(aryl), —SO2CH3 or —Si(CH3) 3; R3 is —OCH3, —OCH2CH3, —F or —Cl; and R4 is —OCH3, —OCH2CH3 or —SCH3; wherein when R1 is —CH2CH3, R3 is —OCH3, and R4 is —OCH3, then R2 is other than H, —CH3, —CH2CH3, —CH2CH2CH3, —CH(CH3)2, —CH2CH2CH2CH3, —CH2OH, —CH(OH) CH3, —OH, —OCH2CH3, —OCH2CH2CH3, —OCH(CH3)2, —SCH3,Type: ApplicationFiled: September 15, 2023Publication date: April 4, 2024Applicant: The Trustees of Columbia University in the City of New YorkInventors: Michael J. Cunningham, Dalibor Sames, Benjamin Bechand
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Patent number: 11947663Abstract: Disclosed are methods, systems, devices, media, circuits, and other implementations, including a method that includes generating for a code block of a process executing on a controller-based device one or more code block copies defined in a virtual address space of the controller-based device, with the code block of the process being stored in a particular segment of a physical address space of the controller-based device, and with the code block configured to separately map to each of the one or more of the code block copies in the virtual address space. The method further includes processing at least a portion of one of the one or more code block copies defined in the virtual address space when the corresponding code block of the process is to be processed.Type: GrantFiled: September 24, 2020Date of Patent: April 2, 2024Assignee: The Trustees of Columbia University in the City of New YorkInventors: Lakshminarasimhan Sethumadhavan, Miguel Arroyo, Mohamed Tarek Bnziad Mohamed Hassan, Evgeny Manzhosov
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Patent number: 11942321Abstract: Methods and systems for crystallizing a thin film provide a laser beam spot that is continually advanced across tire thin film to create a sustained complete or partial molten zone that is translated across the thin film, and crystallizes to form uniform, small-grained crystalline structures or grains.Type: GrantFiled: July 22, 2022Date of Patent: March 26, 2024Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN CITY OF NEW YORKInventors: James S. Im, Wenkai Pan
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Patent number: 11940616Abstract: A switchable light transmission module is disclosed that includes a substrate having a first surface defining at least part of an enclosed volume, a porous layer disposed on the first surface and in fluid communication with the enclosed volume, and a reservoir in fluid communication with the enclosed volume. The reservoir is configured to supply a fluid to the sealed volume such that the fluid contacts the porous layer. The fluid has a refractive index that is close to the refractive index of the porous layer, has a high wettability for the porous layer, and does not dissolve the porous layer. When in a dry state, voids in the porous layer are filled with air which has a much different refractive index than the porous layer itself, resulting in a surface that is reflective and not very transmissive.Type: GrantFiled: December 10, 2018Date of Patent: March 26, 2024Assignee: The Trustees of Columbia University in the City of New YorkInventors: Jyotirmoy Mandal, Yuan Yang, Nanfang Yu
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Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
Patent number: 11939631Abstract: This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides.Type: GrantFiled: August 18, 2021Date of Patent: March 26, 2024Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Jingyue Ju, Dae Hyun Kim, Lanrong Bi, Qinglin Meng, Xiaoxu Li