Abstract: A CDMS may include an ELIT having a charge detection cylinder (CD), a charge generator for generating a high frequency charge (HFC), a charge sensitive preamplifier (CP) having an input coupled to the CD and an output configured to produce a charge detection signal (CHD) in response to a charge induced on the CD, and a processor configured to (a) control the charge generator to induce an HFC on the CD, (b) control operation of the ELIT to cause a trapped ion to oscillate back and forth through the CD each time inducing a charge thereon, and (c) process CHD to (i) determine a gain factor as a function of the HFC induced on the CD, and (ii) modify a magnitude of the portion of CHD resulting from the charge induced on the CD by the trapped ion passing therethrough as a function of the gain factor.
Type:
Grant
Filed:
September 8, 2021
Date of Patent:
February 28, 2023
Assignee:
The Trustees Of Indiana University
Inventors:
Martin F. Jarrold, Andrew W. Alexander, Aaron R. Todd
Abstract: Disclosed herein are compounds that can act as inhibitors of nicotinamide phosphoribosyltransferase (“NAMPT”), and methods for their use in treating or preventing diseases, such as pulmonary arterial hypertension (“PAH”). The compounds described herein can include compounds of Formula (II) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.
Type:
Grant
Filed:
February 5, 2019
Date of Patent:
February 21, 2023
Assignees:
THE TRUSTEES OF INDIANA UNIVERSITY, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Inventors:
Tom G. Driver, Roberto F. Machado, Najing Su, Xinyu Guan, Wrickban Mazumdar, Kira Ratia, Jason Ralph Hickok, Angelia Denise Lockett
Abstract: A system and method for data acquisition in a wireless sensor network include receiving measurements made by a plurality of sensor nodes in the wireless sensor network during a given time period, the measurements being carried in data packets that are routed from the plurality of sensor nodes to a base node. The system and method also include determining a plurality of routing paths for the data packets based on routing topology tomography. The system and method further include determining a measurement matrix and a representation basis, and acquiring sensor signals in the wireless sensor network based on the measurement matrix and the representation basis.
Abstract: In certain aspects, the present disclosure provides methods and materials for the treatment of cancer. In accordance with some forms, the disclosure provides methods for the treatment of cancer which include inhibition of ubiquitin carboxyl-terminal hydrolase.
Abstract: A charge detection mass spectrometer may include an ion source, an electrostatic linear ion trap (ELIT) including a charge detection cylinder disposed between a pair of coaxially aligned ion mirrors, means for selectively establishing electric fields within the ion mirrors configured to cause the trapped ions in the ELIT to oscillate back and forth between the ion mirrors each time passing through the charge detection cylinder, and means for controlling a trajectory of the beam of ions entering the ELIT to cause the subsequently trapped ions to oscillate with different planar ion oscillation trajectories angularly offset from one another about the longitudinal axis with each extending along and crossing the longitudinal axis in each of the ion mirrors or with different cylindrical ion oscillation trajectories radially offset from one another about the longitudinal axis to form nested cylindrical trajectories each extending along the longitudinal axis.
Abstract: An instrument for separating ions may include an ion source in a first pressure environment at a first pressure and configured to generate ions from a sample, an ion separation instrument, controlled to an instrument pressure that is less than the first pressure, and configured to separate ions as a function of at least one molecular characteristic and an interface, controlled to a second pressure less than the first pressure and greater than the instrument pressure, for transporting the generated ions from the first pressure environment into the ion separation instrument operating at the instrument pressure. The interface may include a sealed ion funnel defining an axial passageway therethrough, and an ion carpet sealed to the first ion funnel. A portion of the axial passageway tapers from a first cross-sectional area to a reduced cross-sectional area such that the tapered axial passageway defining a virtual jet disrupter therein.
Type:
Grant
Filed:
September 8, 2021
Date of Patent:
December 20, 2022
Assignee:
The Trustees Of Indiana University
Inventors:
Martin F. Jarrold, Staci N. Anthony, Benjamin E. Draper
Abstract: Methods of treating a valvular heart disease are provided. Methods for treating valvular heard disease include administering to a subject a therapeutically effective amount of at least one hedgehog pathway inhibitor. Also provided are methods for reducing fibrosis in a subject, which comprise administering to the subject a therapeutically effective amount of at least one hedgehog pathway inhibitor.
Abstract: An orbitrap may include elongated inner and outer electrodes, wherein the inner and outer electrodes each define two axially spaced apart electrode halves with a central transverse plane extending through the electrodes also passing between both sets of electrode halves, a cavity defined radially about and axially along the inner electrode between the two inner electrode halves and the two outer electrode halves, means for establishing an electric field configured to trap an ion in the cavity and to cause the trapped ion to rotate about, and oscillate axially along, the inner electrode, wherein the rotating and oscillating ion induces charges on the inner and outer electrode halves, and charge detection circuitry configured to detect the charges induced on the inner and on outer electrode halves, and to combine the detected charges for each oscillation to produce a measured ion charge signal.
Abstract: A method and apparatus for correcting an error in depth information estimated from a two-dimensional (2D) image are disclosed. The method includes diagnosing an error in depth information by inputting a color image and depth information estimated using the color image to a depth error detection network, and determining enhanced depth information by maintaining or correcting the depth information based on the diagnosed error.
Type:
Application
Filed:
May 3, 2021
Publication date:
November 3, 2022
Applicants:
Electronics and Telecommunications Research Institute, The Trustees of Indiana University
Inventors:
Soon Heung JUNG, Jeongil SEO, Jagpreet Singh CHAWLA, Nikhil THAKURDESAI, David CRANDALL, Md REZA, Anuj GODASE
Abstract: The invention describes single-site metal catalysts such as Pt single-site centers on powdered oxide supports with a 1,10-phenanthroline-5,6-dione (PDO) or bis-pyrimidyltetrazine (BMTZ) ligand on powdered MgO, Al2O3, or CeO2.
Abstract: Disclosed are a method for coding a residual signal of LPC coefficients based on collaborative quantization and a computing device for performing the method. The residual signal coding method includes: generating encoded LPC coefficients and LPC residual signals by performing LPC analysis and quantization on an input speech; Determining a predicted LPC residual signal by applying the LPC residual signal to cross module residual learning; Performing LPC synthesis using the coded LPC coefficients and the predicted LPC residual signal; It may include the step of determining an output speech that is a synthesized output according to a result of performing the LPC synthesis.
Type:
Grant
Filed:
November 13, 2020
Date of Patent:
November 1, 2022
Assignees:
Electronics and Telecommunications Research Institute, The Trustees of Indiana University
Inventors:
Minje Kim, Kai Zhen, Mi Suk Lee, Seung Kwon Beack, Jongmo Sung, Tae Jin Lee, Jin Soo Choi
Abstract: Syringe pump controllers which memorialize the process of hydrodynamic isotonic saline delivery (HIFD) to reverse acute kidney injury are disclosed. In some embodiments, the syringe pump controllers are constructed to control syringe pump(s) to deliver a defined volume of saline at a prescribed perfusion rate while monitoring renal vein pressures during the infusion. In some embodiments, the syringe pump controllers have safety features designed to shut off the infusion if the renal vein pressure goes above set safety limits.
Type:
Application
Filed:
September 17, 2020
Publication date:
October 20, 2022
Applicants:
The Trustees of Indiana University, The United States Government as represented by the Department of Veterans Affairs
Inventors:
Mark S. Carlsen, Gregory S. Eakins, Robert M. Everly, Catherine L. McIntyre, Phillip J. Wyss, Robert L. Bacallao
Abstract: The invention describes single-site metal catalysts such as Pt single-site centers with a 3,6-di-2-pyridyl-1,2,4,5-tetrazine (DPTZ) ligand on support such as a powdered MgO, Al2O3, CeO2 or mixtures thereof.
Abstract: A Transactivator of Transcription-frataxin (TAT-FXN) fusion polypeptide useful in treating subjects diagnosed with Friedreich's Ataxia, hypertrophic cardiomyopathy, or both are disclosed, as are related methods of treatment and pharmaceutical compositions.
Abstract: A porous microstructure includes: a solid material, wherein the solid material allows conductivity of ions; and a plurality of nanopores defined within the solid material.
Type:
Application
Filed:
September 8, 2020
Publication date:
September 8, 2022
Applicant:
The Trustees of Indiana University
Inventors:
Likun Zhu, Shengfeng Yang, Xinwei Zhou, Yuzi Liu
Abstract: Provided is a training method of a neural network that is applied to an audio signal encoding method using an audio signal encoding apparatus, the training method including generating a masking threshold of a first audio signal before training is performed, calculating a weight matrix to be applied to a frequency component of the first audio signal based on the masking threshold, generating a weighted error function obtained by correcting a preset error function using the weight matrix, and generating a second audio signal by applying a parameter learned using the weighted error function to the first audio signal.
Type:
Grant
Filed:
September 5, 2018
Date of Patent:
August 16, 2022
Assignees:
Electronics and Telecommunications Research Institute, THE TRUSTEES OF INDIANA UNIVERSITY
Inventors:
Jongmo Sung, Minje Kim, Aswin Sivaraman, Kai Zhen
Abstract: Methods for calculating the radiation dose to the immune system of a patient undergoing radiotherapy are provided. In particular, the methods provide for calculating an effective dose to blood (EDIC) to circulating immune cells. The methods can be incorporated into radiotherapy (RT) treatment planning systems, which are also provided. The methods can be used to optimize patient treatment plans. Methods for treating a patient with RT with an optimized treatment plan are provided.
Type:
Grant
Filed:
May 2, 2018
Date of Patent:
July 19, 2022
Assignee:
The Trustees of Indiana University
Inventors:
Jian-Yue Jin, Feng-Ming Kong, Hong Zhang, Huan Yao
Abstract: A resonance podium includes a plurality of walls defining a frame of the resonance podium. A top panel is coupled to the plurality of walls to form a top surface that supports a performer playing a musical instrument on the resonance podium. A resonant panel is also coupled to the plurality of walls and isolated from the top panel. The resonant panel is configured to receive a portion of the musical instrument and to project structurally-transmitted vibrations from the musical instrument for acoustical amplification.
Abstract: Methods, systems, and devices to improve the assessment of visual function and overcoming limitations of current methods to identify the visual function that potentially could be reached by a given eye. Multiple eye tests including visual stimuli plus optical measurement components, and methods to combine the results, identify and quantify sources of decreased vision resulting from optical sources, such as a lens and cornea as distinguished from retinal sources. By identifying potentially correctable optical sources of decreased vision, and overcoming physiological limitations such as size of the eye's pupil, the visual benefits of treatment such as by cataract or corneal surgery are distinguished from retinal pathology that requires medical intervention. The devices and methods provide metrics that include an expected value of the visual function and sources of variability including both optical and neural components, to guide treatment and improve clinical trials.
Abstract: A charge detection mass spectrometer may include an electrostatic linear ion trap (ELIT) or an orbitrap, an ion source to supply ions thereto, at least one amplifier operatively coupled to the ELIT or orbitrap, a processor coupled to ELIT or orbitrap and to the amplifier(s), and processor programmed to control the ELIT or orbitrap as part of a trapping event to attempt to trap therein a single ion supplied by the ion source, to record ion measurement information based on output signals produced by the amplifier(s) over a duration of the trapping event, to determine, based on the measurement information, whether the control of the ELIT or orbitrap resulted in trapping of a single ion, no ion or multiple ions, and to compute an ion mass or mass-to-charge ratio from the measurement information only if a single ion was trapped during the trapping event.